Susceptibility to disease (tropical theileriosis) is associated with differential expression of host genes that possess motifs recognised by a pathogen DNA binding protein

Autor: Larcombe, Stephen D., Capewell, Paul, Jensen, Kirsty, Weir, William, Kinnaird, Jane, Glass, Elizabeth J., Shiels, Brian R.

Publikováno v: PLoS ONE, Vol 17, Iss 1 (2022)
PLoS ONE
Larcombe, S D, Capewell, P, Jensen, K, Weir, W, Kinnaird, J, Glass, E J & Shiels, B R 2022, ' Susceptibility to disease (tropical theileriosis) is associated with differential expression of host genes that possess motifs recognised by a pathogen DNA binding protein ', PLoS ONE, vol. 17, no. 1, e0262051 . https://doi.org/10.1371/journal.pone.0262051
PLoS ONE, Vol 17, Iss 1, p e0262051 (2022)

Background Knowledge of factors that influence the outcome of infection are crucial for determining the risk of severe disease and requires the characterisation of pathogen-host interactions that have evolved to confer variable susceptibility to infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29a0000beb9c34e119287b7f79bed48
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782480/?tool=EBI

Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy

Autor: Cécile Ribot, Cédric Soler, Aymeric Chartier, Sandy Al Hayek, Rima Naït-Saïdi, Nicolas Barbezier, Olivier Coux, Martine Simonelig

Publikováno v: PLoS Genetics, Vol 18, Iss 1, p e1010015 (2022)
PLoS Genetics
PLoS Genetics, 2022, 18 (1), pp.e1010015. ⟨10.1371/journal.pgen.1010015⟩

Oculopharyngeal muscular dystrophy (OPMD) is a late-onset disorder characterized by progressive weakness and degeneration of specific muscles. OPMD is due to extension of a polyalanine tract in poly(A) binding protein nuclear 1 (PABPN1). Aggregation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c39c64adaa3353b2b4a97f01ff0ef62
https://doaj.org/article/c0ad9bc556604a2a99af3e68628adc08

Identification of genes involved in exoprotein release using a high-throughput exoproteome screening assay in Yersinia entomophaga

Autor: Marion Schoof, Maureen O’Callaghan, Campbell R. Sheen, Travis R. Glare, Mark R. H. Hurst

Publikováno v: PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0263019 (2022)
PLoS ONE, Vol 17, Iss 1 (2022)

Bacterial protein secretion is crucial to the maintenance of viability and pathogenicity. Although many bacterial secretion systems have been identified, the underlying mechanisms regulating their expression are less well explored. Yersinia entomopha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9f5c412a0e5354a89e89c63ae8a136
http://europepmc.org/articles/PMC8789137

The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence

Autor: Zavala-Alvarado, Crispin, G. Huete, Samuel, Vincent, Antony T., Sismeiro, Odile, Legendre, Rachel, Varet, Hugo, Bussotti, Giovanni, Lorioux, Céline, Lechat, Pierre, Coppée, Jean-Yves, Veyrier, Frédéric J., Picardeau, Mathieu, Benaroudj, Nadia

Publikováno v: PLoS Pathogens

Pathogenic Leptospira are the causative agents of leptospirosis, the most widespread zoonotic infectious disease. Leptospirosis is a potentially severe and life-threatening emerging disease with highest burden in sub-tropical areas and impoverished p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ea883bd05f26f1f2ee3ac845e20b723a
http://europepmc.org/articles/PMC8638851

The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans

Autor: Grassmann, André A., Zavala-Alvarado, Crispin, Bettin, Everton B., Picardeau, Mathieu, Benaroudj, Nadia, Caimano, Melissa J.

Publikováno v: PLoS Pathogens

Leptospira interrogans, the causative agent of most cases of human leptospirosis, must respond to myriad environmental signals during its free-living and pathogenic lifestyles. Previously, we compared L. interrogans cultivated in vitro and in vivo us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c577504fa5a7c80278d85810297661c
http://europepmc.org/articles/PMC8638967