Zobrazeno 1 - 10
of 874
pro vyhledávání: '"Gene Prioritization"'
Autor:
Bishesh Subba, Mohammed Toufiq, Fuadur Omi, Marina Yurieva, Taushif Khan, Darawan Rinchai, Karolina Palucka, Damien Chaussabel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The identification of optimal candidate genes from large-scale blood transcriptomic data is crucial for developing targeted assays to monitor immune responses. Here, we introduce a novel, optimized large language model (LLM)-based approach f
Externí odkaz:
https://doaj.org/article/ad20bd7ebe984191b76d3ee6fcf8d717
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2277-2288 (2024)
The increasing availability of RNA sequencing data has opened up numerous opportunities to analyze various RNA interactions, including microRNA-target interactions (MTIs). In response to the necessity for a specialized tool to study MTIs in cancer an
Externí odkaz:
https://doaj.org/article/ad599bc6619b4fda8f96f06f8f9e82d3
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-15 (2024)
Abstract Background Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal. Although various MPB-associated
Externí odkaz:
https://doaj.org/article/d53c906b15c44335a0e6cfb284ada755
Autor:
Kira J. Stanzick, Klaus J. Stark, Mathias Gorski, Johannes Schödel, René Krüger, Florian Kronenberg, Richard Warth, Iris M. Heid, Thomas W. Winkler
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Genome-wide association studies (GWAS) have identified hundreds of genetic loci associated with kidney function. By combining these findings with post-GWAS information (e.g., statistical fine-mapping to identify independent associ
Externí odkaz:
https://doaj.org/article/144f4c890af4425ca63440a83d0e7947
Autor:
HE Hongyao, JI Chun, Gao Xiaoyan, Liu Fangfang, Zhang Jing, Zhong Lin, Zuo Pengxiang, Li Zengchun
Publikováno v:
BMC Medical Genomics, Vol 16, Iss 1, Pp 1-17 (2023)
Abstract Background Attention deficit hyperactivity disorder (ADHD) is commonly associated with developmental dyslexia (DD), which are both prevalent and complicated pediatric neurodevelopmental disorders that have a significant influence on children
Externí odkaz:
https://doaj.org/article/293d79212a9e4564b119a1daf36152bd
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Background: Alzheimer’s disease (AD) is a complex disorder, and its risk is influenced by multiple genetic and environmental factors. In this study, an AD risk gene prediction framework based on spatial and temporal features of gene expression data
Externí odkaz:
https://doaj.org/article/b22d35c6571e42d4ac15f1443ce28a0e
Publikováno v:
MGM Journal of Medical Sciences, Vol 10, Iss 4, Pp 610-620 (2023)
Background: The present study aimed to identify biomarker genes associated with disease progression from an early and advanced stage to metastatic oral squamous cell carcinoma (OSCC) and to explore their regulatory mechanism. Materials and Methods: T
Externí odkaz:
https://doaj.org/article/f8b33fa6f055405fb8239b758fbe95b5
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 34-45 (2023)
Cancer is a heterogeneous disease mainly driven by abnormal gene perturbations in regulatory networks. Therefore, it is appealing to identify the common and specific perturbed genes from multiple cancer networks. We developed an integrative network m
Externí odkaz:
https://doaj.org/article/2b5823cc05ad4256a425fd3bec99f248
Autor:
Saranya G. Narayana, Ellen de Jong, Flavio S. Schenkel, Pablo A.S. Fonseca, Tatiane C.S. Chud, Diana Powell, Garrett Wachoski-Dark, Paul E. Ronksley, Filippo Miglior, Karin Orsel, Herman W. Barkema
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 1, Pp 323-351 (2023)
ABSTRACT: Mastitis, the most frequent disease in dairy cattle. Resistance to mastitis is a complex, polygenic trait controlled by several genes, each with small effects. Genome-wide association studies have been widely used to identify genomic varian
Externí odkaz:
https://doaj.org/article/3e3c10a608544c848ececf3d52da7f5c
Autor:
Althagafi, Azza Th.
Whole-exome and genome sequencing are widely used to diagnose individual patients. However, despite its success, this approach leaves many patients undiagnosed. This could be due to the need to discover more disease genes and variants or because dise
Externí odkaz:
http://hdl.handle.net/10754/693761
