Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gene P. Ables"'
Autor:
Diana Cooke, Gene P. Ables
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Please use the attached pdf file for corrections. Sulfur amino acid restriction (SAAR)—the reduction of methionine and cysteine concentrations either in the diet or by genetic manipulation—promotes health span and extends lifespan, but i
Externí odkaz:
https://doaj.org/article/bf307525440d493391f149376b45a1d4
Publikováno v:
Bone Reports, Vol 5, Iss , Pp 33-42 (2016)
Methionine restriction (MR) extends the lifespan of a wide variety of species, including rodents, drosophila, nematodes, and yeasts. MR has also been demonstrated to affect the overall growth of mice and rats. The objective of this study was to evalu
Externí odkaz:
https://doaj.org/article/371f980d0ab84c05a8794f5f7951421e
Autor:
Gene P. Ables, Kryscilla Jian Zhang Yang, Silke Vogel, Antonio Hernandez-Ono, Shuiqing Yu, Jason J. Yuen, Susan Birtles, Linda K. Buckett, Andrew V. Turnbull, Ira J. Goldberg, William S. Blaner, Li-Shin Huang, Henry N. Ginsberg
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 11, Pp 2364-2379 (2012)
Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 catalyzes the final step of triglyceride (TG) synthesis. We show that acute administration of a DGAT1 inhibitor (DGAT1i) by oral gavage or genetic deletion of intestinal Dgat1 (intestine-Dgat1−/−)
Externí odkaz:
https://doaj.org/article/ef0ae0cad15247f89a3efeb1b1b8818c
Autor:
Li Liu, Shuiqing Yu, Raffay S. Khan, Gene P. Ables, Kalyani G. Bharadwaj, Yunying Hu, Lesley A. Huggins, Jan W. Eriksson, Linda K. Buckett, Andrew V. Turnbull, Henry N. Ginsberg, William S. Blaner, Li-Shin Huang, Ira J. Goldberg
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 4, Pp 732-744 (2011)
Diacylglycerol (DAG) acyl transferase 1 (Dgat1) knockout (−/−) mice are resistant to high-fat-induced obesity and insulin resistance, but the reasons are unclear. Dgat1−/− mice had reduced mRNA levels of all three Ppar genes and genes involve
Externí odkaz:
https://doaj.org/article/28b9b4fb4e8e4a7880d03b89710adc64
Autor:
Gene P. Ables
Publikováno v:
PPAR Research, Vol 2012 (2012)
Nonalcoholic fatty liver disease (NAFLD) is the most common initial presentation of obesity and insulin resistance. Uninterrupted progression of hepatic lipid accumulation often leads to fatty liver disease and eventually cirrhosis. Insulin resistanc
Externí odkaz:
https://doaj.org/article/f219d3009dc94d7bb64e2e8f6234b063
Autor:
Thomas M. Jeitner, Juan A. Azcona, Gene P. Ables, Diana Cooke, Mark C. Horowitz, Pradeep Singh, James M. Kelly, Arthur J. L. Cooper
Publikováno v:
GeroScience.
Dietary methionine restriction (MR) increases longevity by improving health. In experimental models, MR is accompanied by decreased cystathionine β-synthase activity and increased cystathionine γ-lyase activity. These enzymes are parts of the trans
Autor:
Sailendra N. Nichenametla, Dwight A. L. Mattocks, Diana Cooke, Vishal Midya, Virginia L. Malloy, Wilfredo Mansilla, Bente Øvrebø, Cheryl Turner, Nasser E. Bastani, Jitka Sokolová, Markéta Pavlíková, John P. Richie, Anna K. Shoveller, Helga Refsum, Thomas Olsen, Kathrine J. Vinknes, Viktor Kožich, Gene P. Ables
Publikováno v:
Aging Cell. 21
SummaryDecreasing dietary intake of methionine exerts robust anti-adiposity effects in rodents but modest effects in humans. Since cysteine can be synthesized from methionine, animal diets are formulated by decreasing methionine and eliminating cyste
Autor:
Gene P. Ables, Diana Cooke, Dwight A.L. Mattocks, Rea P. Anunciado-Koza, Sailendra N. Nichenametla, Robert A. Koza
Publikováno v:
Obesity (Silver Spring)
Objective Identifying novel approaches to combat obesity is important to improve health span. It was hypothesized that methionine restriction (MR) will induce weight loss in obese mice by reducing adipose tissue mass caused by increased energy expend
Autor:
Ana Calcagnotto, Sydney M. Sanderson, John P. Richie, Peter G. Mikhael, Michael A. Reid, David S. Hsu, Samantha J. Mentch, Min Lu, Amy Ciccarella, David G. Kirsch, Gene P. Ables, Xia Gao, Juan Liu, Daniel E. Cooper, Sailendra N. Nichenametla, Jason W. Locasale, Ziwei Dai
Publikováno v:
Nature. 572:397-401
Nutrition exerts considerable effects on health, and dietary interventions are commonly used to treat diseases of metabolic aetiology. Although cancer has a substantial metabolic component1, the principles that define whether nutrition may be used to
Autor:
Gene P. Ables
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8153668f117325a946af087a730809b9
https://doi.org/10.1016/b978-0-12-819460-7.00061-x
https://doi.org/10.1016/b978-0-12-819460-7.00061-x