Zobrazeno 1 - 10
of 437
pro vyhledávání: '"Gene P. Siegal"'
Autor:
Brooke B. Bartow, Gene P. Siegal, Ceren Yalniz, Ahmed M. Elkhanany, Lei Huo, Qingqing Ding, Aysegul A. Sahin, Hua Guo, Cristina Magi-Galluzzi, Shuko Harada, Xiao Huang
Publikováno v:
Cancers, Vol 15, Iss 9, p 2524 (2023)
Poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPis) have demonstrated antitumor activity in cancers with a homologous recombination deficiency (HRD) and have recently been approved by the FDA for the treatment of germline BRCA1/2-mutat
Externí odkaz:
https://doaj.org/article/4f6181383d624a61afeee2b263e082a2
Autor:
Hope M. Amm, Patricia DeVilliers, Ambika R. Srivastava, Marina G. Diniz, Gene P. Siegal, Mary MacDougall
Publikováno v:
Clinical and Experimental Dental Research, Vol 6, Iss 5, Pp 495-505 (2020)
Abstract Background Undifferentiated pleomorphic sarcomas are one of the most common subtypes of soft tissue sarcomas. These are aggressive mesenchymal tumors and are devoid of the major known biomarkers except vimentin. Our objective was to establis
Externí odkaz:
https://doaj.org/article/00262239d7cb4c7b8bc19bc7fd98308e
Autor:
Brian Spurlock, Danitra Parker, Malay Kumar Basu, Anita Hjelmeland, Sajina GC, Shanrun Liu, Gene P Siegal, Alan Gunter, Aida Moran, Kasturi Mitra
Publikováno v:
eLife, Vol 10 (2021)
Gene knockout of the master regulator of mitochondrial fission, Drp1, prevents neoplastic transformation. Also, mitochondrial fission and its opposing process of mitochondrial fusion are emerging as crucial regulators of stemness. Intriguingly, stem/
Externí odkaz:
https://doaj.org/article/2ab7693ce4904efebfa69daa7782a588
Publikováno v:
Human Pathology: Case Reports, Vol 24, Iss , Pp 200499- (2021)
Herein, we present the case of a 35-year-old man with a previous history of osteosarcoma of his left tibia followed by multiple episodes of bilateral pulmonary metastases. After being clinically free of disease for seven years, the patient developed
Externí odkaz:
https://doaj.org/article/64c03ef0e2ba40d9b87983d8079ed807
Autor:
Victor, Zota, Gene P, Siegal, David, Kelly, Julia A, Bridge, Anders, Berglund, Katherine, Bui, Farah, Khalil, Damon, R Reed, Soner, Altiok, Anthony, Magliocco, Marilyn M, Bui
Publikováno v:
Fetal and Pediatric Pathology. 42:241-252
Supplementary Table 1 PDF file - 64K, Association of p-�-CaMKII IHC staining with osteosarcoma subtypes compared to normal bone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a507e947dace8288d0f78ca43aa839d
https://doi.org/10.1158/1541-7786.22510077
https://doi.org/10.1158/1541-7786.22510077
Supplementary Table 2 PDF file - 68K, Association of p-�-CaMKII IHC staining with osteosarcoma grade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2d16aaddbff1e70e47da5a1bef9d26
https://doi.org/10.1158/1541-7786.22510074
https://doi.org/10.1158/1541-7786.22510074
Osteosarcoma is among the most frequently occurring primary bone tumors, primarily affecting adolescents and young adults. Despite improvements in osteosarcoma treatment, more specific molecular targets are needed as potential therapeutic options. On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0a348d6ef025a3f3bb9215d5b9c181
https://doi.org/10.1158/1541-7786.c.6539499
https://doi.org/10.1158/1541-7786.c.6539499
Purpose: Overexpression of transforming growth factor (TGF)-β has been implicated in promoting immune suppression, tumor angiogenesis, tumor cell migration, and invasion in many cancers, including carcinoma of the breast. Thus, targeted down-regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9b07d3bec6a43c3c1c598c93b43bcf
https://doi.org/10.1158/1078-0432.c.6516804.v1
https://doi.org/10.1158/1078-0432.c.6516804.v1
Autor:
Ronald D. Alvarez, David T. Curiel, Kurt R. Zinn, Gene P. Siegal, Rosemarie Aurigemma, Raymond D. Harris, Meredith A. Preuss, Zhiying You, Souheil Saddekni, Minghui Wang, Janis P. O'Malley, Igor Dmitriev, Kenneth H. Kim
PDF file - 43K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6885887cd3ad13f74e38ed8dcadc41
https://doi.org/10.1158/1078-0432.22444520.v1
https://doi.org/10.1158/1078-0432.22444520.v1