Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Gene L. Bidwell"'
Autor:
Komal Beeton, Dipanwita Mitra, Adesanya A. Akinleye, John A. Howell, Christian S. Yu, Gene L. Bidwell, Ritesh Tandon
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The tegument protein pp150 of Human Cytomegalovirus (HCMV) is known to be essential for the final stages of virus maturation and mediates its functions by interacting with capsid proteins. Our laboratory has previously identified the critica
Externí odkaz:
https://doaj.org/article/3e72a7ba30c5479aa9d01fd2bf134f78
Autor:
Chirag P. Talati, Jonathan W. Lee, Silu Lu, Norma B. Ojeda, Varsha Prakash, Nilesh Dankhara, Tanner C. Nielson, Sara P. Sandifer, Gene L. Bidwell, III, Yi Pang, Lir-Wan Fan, Abhay J. Bhatt
Publikováno v:
Current Research in Neurobiology, Vol 6, Iss , Pp 100123- (2024)
There is a significant need for additional therapy to improve outcomes for newborns with acute Hypoxic-ischemic (HI) encephalopathy (HIE). New evidence suggests that insulin could be neuroprotective. This study aimed to investigate whether intranasal
Externí odkaz:
https://doaj.org/article/c5866217c1194bc5a5780a39a5c782b4
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Vascular Endothelial Growth Factor (VEGF), a key mediator of angiogenesis and vascular repair, is reduced in chronic ischemic renal diseases, leading to microvascular rarefaction and deterioration of renal function. We developed a chimeric f
Externí odkaz:
https://doaj.org/article/8a90e0ab576444fa94b0057516ab228f
Publikováno v:
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-11 (2018)
Abstract Preeclampsia is a pregnancy-induced hypertensive disorder resulting from abnormal placentation, which causes factors such as sFlt-1 to be released into the maternal circulation. Though anti-hypertensive drugs and magnesium sulfate can be giv
Externí odkaz:
https://doaj.org/article/b66bb0f94c3944f5878e37f4ae11ce7a
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Elastin-like polypeptides (ELP) are engineered proteins that consist of repetitions of a five amino acid motif, and their composition is easily modified to adjust their physical properties and attach therapeutics. Because of the repetitive n
Externí odkaz:
https://doaj.org/article/8dd0e54fcfa440c3ba3d326e23c06e82
Publikováno v:
Viruses, Vol 13, Iss 11, p 2277 (2021)
Human cytomegalovirus (HCMV) tegument protein pp150 is essential for the completion of the final steps in virion maturation. Earlier studies indicated that three pp150nt (N-terminal one-third of pp150) conformers cluster on each triplex (Tri1, Tri2A
Externí odkaz:
https://doaj.org/article/bb915d78c1114fd0b9b2e87d081861e6
Publikováno v:
Pharmaceutics, Vol 11, Iss 10, p 542 (2019)
Elastin-like polypeptides (ELP) are versatile protein biopolymers used in drug delivery due to their modular nature, allowing fusion of therapeutics and targeting agents. We previously developed an ELP fusion with vascular endothelial growth factor (
Externí odkaz:
https://doaj.org/article/72231c518dda42a8a65acc2d7bcec9de
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 12 (2017)
BackgroundPreeclampsia is a hypertensive syndrome that complicates 3% to 5% of pregnancies in the United States. Preeclampsia originates from an improperly vascularized and ischemic placenta that releases factors that drive systemic pathophysiology.
Externí odkaz:
https://doaj.org/article/e156a79a396049f3ae33d9627d9fa59f
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 16, p 4051 (2019)
Offspring of preeclampsia patients have an increased risk of developing neurological deficits and cognitive impairment. While low placental perfusion, common in preeclampsia and growth restriction, has been linked to neurological deficits, a causativ
Externí odkaz:
https://doaj.org/article/d7f1e9007a944cb0a2efd6f5f8500360
Autor:
Usman M, Ashraf, Dalton L, Hall, Nathan, Campbell, Jamarius P, Waller, Adam Z, Rawls, Dylan, Solise, Kathy, Cockrell, Gene L, Bidwell, Damian G, Romero, Norma B, Ojeda, Babbette, LaMarca, Barbara T, Alexander
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 323(5)
Placenta ischemia, the initiating event in preeclampsia (PE), is associated with fetal growth restriction. Inhibition of the agonistic autoantibody against the angiotensin type 1 receptor AT