Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Gene Hart"'
Autor:
Kim L. McIntyre, Shafagh A. Waters, Ling Zhong, Gene Hart-Smith, Mark Raftery, Zahra A. Chew, Hardip R. Patel, Jennifer A. Marshall Graves, Paul D. Waters
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-19 (2024)
Abstract The marsupial specific RSX lncRNA is the functional analogue of the eutherian specific XIST, which coordinates X chromosome inactivation. We characterized the RSX interactome in a marsupial representative (the opossum Monodelphis domestica),
Externí odkaz:
https://doaj.org/article/060615f1445d423c8851ce816efb87ee
Autor:
Frances L. Byrne, Ellen M. Olzomer, Gabriella R. Marriott, Lake-Ee Quek, Alice Katen, Jacky Su, Marin E. Nelson, Gene Hart-Smith, Mark Larance, Veronica F. Sebesfi, Jeff Cuff, Gabriella E. Martyn, Elizabeth Childress, Stephanie J. Alexopoulos, Ivan K. Poon, Maree C. Faux, Antony W. Burgess, Glen Reid, Joshua A. McCarroll, Webster L. Santos, Kate GR. Quinlan, Nigel Turner, Daniel J. Fazakerley, Naresh Kumar, Kyle L. Hoehn
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical library screening approach to identify molecules that
Externí odkaz:
https://doaj.org/article/5e4c5baf666144d5a43fe60f14c4e6fb
Autor:
Caroline Bouchard, Peeyush Sahu, Marion Meixner, René Reiner Nötzold, Marco B. Rust, Elisabeth Kremmer, Regina Feederle, Gene Hart-Smith, Florian Finkernagel, Marek Bartkuhn, Soni Savai Pullamsetti, Andrea Nist, Thorsten Stiewe, Sjaak Philipsen, Uta-Maria Bauer
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3339-3352 (2018)
Summary: Protein arginine methyltransferase 6 (PRMT6) catalyzes asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a). This mark has been reported to associate with silent genes. Here, we use a cell model of neural differentiation, which up
Externí odkaz:
https://doaj.org/article/064477c346a2492aa5960b13e200bd05
Publikováno v:
FEBS Open Bio, Vol 6, Iss 12, Pp 1320-1330 (2016)
The Family 16 methyltransferases are a group of eukaryotic nonhistone protein methyltransferases. Sixteen of these have recently been described in yeast and human, but little is known about their sequence and structural features. Here we investigate
Externí odkaz:
https://doaj.org/article/9bddbfaacf314c09b6e8f3540a3ca5a5
Autor:
Chris K. Hewson, Alexander Capraro, Sharon L. Wong, Elvis Pandzic, Ling Zhong, Bentotage S. M. Fernando, Nikhil T. Awatade, Gene Hart-Smith, Renee M. Whan, Shane R. Thomas, Adam Jaffe, Wallace J. Bridge, Shafagh A. Waters
Publikováno v:
Antioxidants, Vol 9, Iss 12, p 1204 (2020)
Systemic glutathione deficiency, inflammation, and oxidative stress are hallmarks of cystic fibrosis (CF), an inherited disease that causes persistent lung infections and severe damage to the respiratory system and many of the body organs. Improvemen
Externí odkaz:
https://doaj.org/article/ded626cf578c43c38dbe8569a71c6601
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 888-897 (2015)
Cholesterol is essential to human health, and its levels are tightly regulated by a balance of synthesis, uptake, and efflux. Cholesterol synthesis requires the actions of more than twenty enzymes to reach the final product, through two alternate pat
Externí odkaz:
https://doaj.org/article/0edb925724c042fb831c75c0dae361c4
Publikováno v:
Frontiers in Plant Science, Vol 8 (2017)
Quantitative proteomics strategies – which are playing important roles in the expanding field of plant molecular systems biology – are traditionally designated as either hypothesis driven or non-hypothesis driven. Many of these strategies aim to
Externí odkaz:
https://doaj.org/article/b302f80cb91941a0a528f39fd991ad9a
Autor:
Tatiana A Soboleva, Brian J Parker, Maxim Nekrasov, Gene Hart-Smith, Ying Jin Tay, Wei-Quan Tng, Marc Wilkins, Daniel Ryan, David J Tremethick
Publikováno v:
PLoS Genetics, Vol 13, Iss 2, p e1006633 (2017)
The replacement of histone H2A with its variant forms is critical for regulating all aspects of genome organisation and function. The histone variant H2A.B appeared late in evolution and is most highly expressed in the testis followed by the brain in
Externí odkaz:
https://doaj.org/article/bd7cacc1f9b64fd79a570f756c5e1f59
Autor:
Isabelle M. Capell-Hattam, Anika V. Prabhu, Andrew J. Brown, Lydia Qian, Gene Hart-Smith, Laura J. Sharpe
Publikováno v:
J Biol Chem
Cholesterol synthesis is a tightly regulated process, both transcriptionally and post-translationally. Transcriptional control of cholesterol synthesis is relatively well-understood. However, of the ∼20 enzymes in cholesterol biosynthesis, post-tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebef66e753169f7955b4d1d5fc21fcc8
https://doi.org/10.1074/jbc.ra119.011323
https://doi.org/10.1074/jbc.ra119.011323
Autor:
Yu-Wen Lai, Melissa A. Erce, Daniela-Lee Smith, Joshua J. Hamey, Marc R. Wilkins, Gene Hart-Smith, Florence Tomasetig
Publikováno v:
Journal of Molecular Biology. 432:448-466
Crosstalk exists when two or more post-translational modifications, nearby in sequence or 3D space, affect each other or a protein's interactions. Saccharomyces cerevisiae protein Npl3p has six repeats of sequence SRGG, in a disordered domain, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5774c4d82d4bebd1da65b20ce7257e05
https://doi.org/10.1016/j.jmb.2019.11.006
https://doi.org/10.1016/j.jmb.2019.11.006