Výsledky vyhledávání - "Gene Fusion/genetics"

Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells

Autor: Christophe Fuerer, Richard Iggo, Anne-Laure Pittet, Alexander N Lukashev, Krisztian Homicsko

Publikováno v: BMC Cancer, Vol 6, Iss 1, p 236 (2006)
BMC Cancer
BMC cancer, vol. 6, pp. 236

Background The Wnt signaling pathway is activated by mutations in the APC and β-catenin genes in many types of human cancer. β-catenin is stabilized by these mutations and activates transcription in part by acting as a bridge between Tcf/LEF protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6532acd8806fb8a07be0dab0f1505ed
https://hdl.handle.net/10023/4619

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Tandem chimerism as a means to increase protein complexity in the human genome

Autor: Stylianos E. Antonarakis, Emmanouil T. Dermitzakis, Robert Castelo, Alexandre Reymond, Noura Dabbouseh, Timothy M. Thomson, Roderic Guigó, Genís Parra

Publikováno v: Genome Research, Vol. 16, No 1 (2006) pp. 37-44

The “one-gene, one-protein” rule, coined by Beadle and Tatum, has been fundamental to molecular biology. The rule implies that the genetic complexity of an organism depends essentially on its gene number. The discovery, however, that alternative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e8a48c320ed8a7097cdf5942da6e0d
https://archive-ouverte.unige.ch/unige:8958

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