Zobrazeno 1 - 10
of 1 545
pro vyhledávání: '"Gene Expression and Vector Techniques"'
Publikováno v:
PLoS Genetics
Ivermectin has emerged as very promising pediculicide, particularly in cases of resistance to commonly used pediculicides. Recently, however, the first field-evolved ivermectin-resistance in lice was reported. To gain insight into the mechanisms unde
Autor:
Zi-Yue Chen, Ya-Ting Sun, Zi-Ming Wang, Jie Hong, Min Xu, Fu-Ting Zhang, Xian-Qing Zhou, Ping Rong, Qi Wang, Hong Yu Wang, Hua Wang, Shuai Chen, Liang Chen
Publikováno v:
PLoS Biology, Vol 20, Iss 1, p e3001522 (2022)
PLoS Biology
PLoS Biology
Nonalcoholic fatty liver disease (NAFLD) affects approximately a quarter of the population worldwide, and persistent overnutrition is one of the major causes. However, the underlying molecular basis has not been fully elucidated, and no specific drug
Autor:
Shoh Sasaki, Kensaku Nishihira, Atsushi Yamashita, Tomomi Fujii, Kenji Onoue, Yoshihiko Saito, Kinta Hatakeyama, Yoshisato Shibata, Yujiro Asada, Chiho Ohbayashi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0262413 (2022)
PLoS ONE, Vol 17, Iss 1, p e0262413 (2022)
Activation of the classical complement pathway plays a major role in regulating atherosclerosis progression, and it is believed to have both proatherogenic and atheroprotective effects. This study focused on C1q, the first protein in the classical pa
Autor:
Weingartner, Michael, St��cheli, Simon, Jebbawi, Fadi, Gottstein, Bruno, Beldi, Guido, Lundstr��m-Stadelmann, Britta, Wang, Junhua, Odermatt, Alex
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0009192 (2022)
Weingartner, Michael; Stücheli, Simon; Jebbawi, Fadi; Gottstein, Bruno; Beldi, Guido; Lundström-Stadelmann, Britta; Wang, Junhua; Odermatt, Alex (2022). Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection. PLoS neglected tropical diseases, 16(1), e0009192. Public Library of Science 10.1371/journal.pntd.0009192
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0009192 (2022)
Weingartner, Michael; Stücheli, Simon; Jebbawi, Fadi; Gottstein, Bruno; Beldi, Guido; Lundström-Stadelmann, Britta; Wang, Junhua; Odermatt, Alex (2022). Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection. PLoS neglected tropical diseases, 16(1), e0009192. Public Library of Science 10.1371/journal.pntd.0009192
Background Echinococcus multilocularis causes alveolar echinococcosis (AE), a rising zoonotic disease in the northern hemisphere. Treatment of this fatal disease is limited to chemotherapy using benzimidazoles and surgical intervention, with frequent
Autor:
Jessica W. Chen, Lijuan Yang, Celia Santos, Sergio A. Hassan, Peter L. Collins, Ursula J. Buchholz, Cyril Le Nouën
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010191 (2021)
PLoS Pathogens
PLoS Pathogens
Recoding viral genomes by introducing numerous synonymous nucleotide substitutions that create suboptimal codon pairs provides new live-attenuated vaccine candidates. Because recoding typically involves a large number of nucleotide substitutions, the
Autor:
Zhiyong Bai, Jianlin Feng, Gijs A. C. Franken, Namariq Al’Saadi, Na Cai, Albert S. Yu, Liping Lou, Yuko Komiya, Joost G. J. Hoenderop, Jeroen H. F. de Baaij, Lixia Yue, Loren W. Runnels
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001496 (2021)
Plos Biology, 19, 12
PLoS Biology
Plos Biology, 19
Plos Biology, 19, 12
PLoS Biology
Plos Biology, 19
Magnesium is essential for cellular life, but how it is homeostatically controlled still remains poorly understood. Here, we report that members of CNNM family, which have been controversially implicated in both cellular Mg2+ influx and efflux, selec
Autor:
Jolanda M. Smit, Izabela A. Rodenhuis-Zybert, Andres Merits, Berit Troost-Kind, Martijn J. van Hemert, Malte Borggrewe, Heidi van der Ende-Metselaar, Denise P. I. van de Pol
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009916 (2021)
PLoS Neglected Tropical Diseases, 15(11). PUBLIC LIBRARY SCIENCE
PLoS Neglected Tropical Diseases, 15(11):e0009916. PUBLIC LIBRARY SCIENCE
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, 15(11). PUBLIC LIBRARY SCIENCE
PLoS Neglected Tropical Diseases, 15(11):e0009916. PUBLIC LIBRARY SCIENCE
PLoS Neglected Tropical Diseases
Tomatidine, a natural steroidal alkaloid from unripe green tomatoes has been shown to exhibit many health benefits. We recently provided in vitro evidence that tomatidine reduces the infectivity of Dengue virus (DENV) and Chikungunya virus (CHIKV), t
Autor:
Gina R. Rayat, Yulian Wu, Wenlong Huang, Kaja Matovinovic, Kunsong Chen, Xian Li, Mazzen Black, Jack H. Jhamandas, Nancy Gupta, Wen Fu, Jennifer Croden, Josue Rodrigues Silva
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 10, p e0258208 (2021)
PLoS ONE, Vol 16, Iss 10, p e0258208 (2021)
Islet transplantation is being considered as an alternative treatment for type 1 diabetes. Despite recent progress, transplant recipients continue to experience progressive loss of insulin independence. Cyanidin-3-O-Glucoside (C3G) has shown to be pr
Autor:
Glenda Lassi, Maria Pino-Yanes, Somnath Mukhopadhyay, Roger Tavendale, Antonio Espuela-Ortiz, Karen Wilson, Natalia Hernandez-Pacheco, Colin N. A. Palmer, Simon Young, Steve Turner, Adam Platt, Cyrielle Maroteau, Fiona Carr, Esteban G. Burchard, Anke-Hilse Maitland-van der Zee, Esther Herrera-Luis, James D. Chalmers, Sundararajan Srinivasan
Publikováno v:
PLoS ONE, 16(9 September):e0257396. Public Library of Science
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257396 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257396 (2021)
Leukotrienes play a central pathophysiological role in both paediatric and adult asthma. However, 35% to 78% of asthmatics do not respond to leukotriene inhibitors. In this study we tested the role of theLTA4Hregulatory variant rs2660845 and age of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e583b11172691656d2a829454145a0c7
http://sro.sussex.ac.uk/id/eprint/101847/5/journal.pone.0257396.pdf
http://sro.sussex.ac.uk/id/eprint/101847/5/journal.pone.0257396.pdf
Autor:
Christel Rousseaux, Paolo Spagnolo, Silvia Speca, Caroline Dubuquoy, Pierre Desreumaux, Philippe Chavatte
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
PLoS ONE, Vol 16, Iss 9, p e0257281 (2021)
The development of more effective, better tolerated drug treatments for progressive pulmonary fibrosis (of which idiopathic pulmonary fibrosis is the most common and severe form) is a research priority. The peroxisome proliferator-activated receptor