Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Gene Expression Regulation/immunology"'
1
Interpretation of T cell states from single-cell transcriptomics data using reference atlases
Autor: Massimo, Andreatta, Jesus, Corria-Osorio, Sören, Müller, Rafael, Cubas, George, Coukos, Santiago J, Carmona
Publikováno v: Nature communications, vol. 12, no. 1, pp. 2965
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Single-cell RNA sequencing (scRNA-seq) has revealed an unprecedented degree of immune cell diversity. However, consistent definition of cell subtypes and cell states across studies and diseases remains a major challenge. Here we generate reference T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7aa6ca7323ee966e64c8b77a30c42f7f
https://serval.unil.ch/notice/serval:BIB_BE1D257DF142
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2
Gene activation precedes DNA demethylation in response to infection in human dendritic cells
Autor: Anne Dumaine, Luis B. Barreiro, Ludovic Tailleux, Florence Mailhot-Léonard, Haley E. Randolph, Alain Pacis, Jean-Christophe Grenier, Vania Yotova
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (14), pp.6938-6943. ⟨10.1073/pnas.1814700116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (14), pp.6938-6943. ⟨10.1073/pnas.1814700116⟩
Significance Immune response to infection is accompanied by active demethylation of thousands of CpG sites. Yet, the causal relationship between changes in DNA methylation and gene expression during infection remains to be elucidated. Here, we invest
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16d1ec2f5b67bee7e15b2a518a09f484
http://europepmc.org/articles/PMC6452747
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3
Characterising the genetic basis of immune response variation to identify causal mechanisms underlying disease susceptibility
Autor: Maxime Rotival
Publikováno v: Hla
Hla, 2019, 94 (3), pp.275-284. ⟨10.1111/tan.13598⟩
HLA: Immune Response Genetics
HLA: Immune Response Genetics, 2019, 94 (3), pp.275-284. ⟨10.1111/tan.13598⟩
International audience; Over the last 10 years, genome-wide association studies (GWAS) have identified hundreds of susceptibility loci for autoimmune diseases. However, despite increasing power for the detection of both common and rare coding variant
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5f6d59acaba0397f35813baf81f4ed
https://hal-pasteur.archives-ouvertes.fr/pasteur-02868915/document
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4
Eomes broadens the scope of CD8 T-cell memory by inhibiting apoptosis in cells of low affinity
Autor: Niek de Vries, Anja ten Brinke, Felix M. Wensveen, Niels A. W. Lemmermann, Erik Slinger, Eric Eldering, Doron Merkler, Inga Kavazović, Jan Koster, Hongya Han, Bojan Polić, Stipan Jonjić, Giulia Balzaretti, Yenan T. Bryceson, Paul L. Klarenbeek
Publikováno v: PLoS Biology
PLOS Biology, Vol. 18, No 3 (2020) P. e3000648
PLoS Biology, Vol 18, Iss 3, p e3000648 (2020)
PLoS biology, 18(3):e3000648. Public Library of Science
PLOS Biology
Volume 18
Issue 3
The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5afbb8abf6253d4434b39b4e66cf7be
https://pubmed.ncbi.nlm.nih.gov/32182234
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5
A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity
Autor: Warren J. Leonard, Nima Rezaei, Kathryn Payne, Isabelle Meyts, Laurent Abel, Cindy S. Ma, Marianne Leruez-Ville, Janet Chou, Alain Hovnanian, Jian-Xin Lin, Simon J. Pelham, Danielle T. Avery, Matthieu Bouaziz, Bethany Pillay, Tanwir Habib, Anne Puel, Sevgi Keles, Juan Li, Isabelle Pellier, Jamel El-Benna, Bernhard Fleckenstein, Ahmet Ozen, Vivien Béziat, Ingrid Müller-Fleckenstein, Damien Chaussabel, Samaneh Zoghi, Yi Wang, Paul Gray, Matthias Titeux, Yoann Zerbib, Talal A. Chatila, Marie-Alexandra Alyanakian, Capucine Picard, Orli Wargon, Ayper Somer, Marie-Olivia Chandesris, Thibaut Leclercq, Ibtihal Benhsaien, Aziz Belkadi, Jean-Laurent Casanova, Romain Lévy, Peng Li, Geetha Rao, Ai Ing Lim, James P. Di Santo, Nico Marr, Sylvie Fraitag, Frédégonde About, Elissa K. Deenick, Bertrand Boisson, Jacinta Bustamante, Mélanie Migaud, Bodo Grimbacher, Aziz Bousfiha, Fatima Ailal, Safa Baris, Antoine Guérin, Stuart G. Tangye, Romain Guery, Ning Du, Vimel Rattina
Publikováno v: Science Immunology
Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Science Immunology, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Comment in :Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song. [Sci Immunol. 2018]; International audience; Heterozygosity for human signal transducer and activator of transcription 3 (STAT3) dominant-negative (DN) mutations u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a014e03bf19bbdfb4eb205a53e190a3a
https://doi.org/10.1126/sciimmunol.aat4956
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6
Profiling Atlantic salmon B cell populations:CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression
Autor: Ingvill Jensen, Karsten Skjødt, J. Oriol Sunyer, Shiferaw Jenberie, Jorunn B. Jørgensen, Hanna L. Thim
Publikováno v: Jenberie, S, Thim, H L, Sunyer, J O, Skjødt, K, Jensen, I & Jørgensen, J B 2018, ' Profiling Atlantic salmon B cell populations : CpG-mediated TLR-ligation enhances IgM secretion and modulates immune gene expression ', Scientific Reports, vol. 8, 3565 . https://doi.org/10.1038/s41598-018-21895-9
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
While TLR-activated pathways are key regulators of B cell responses in mammals, their impact on teleost B cells are scarcely addressed. Here, the potential of Atlantic salmon B cells to respond to TLR ligands was shown by demonstrating a constitutive
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21471f62d7f983a0183b092179104b7b
https://findresearcher.sdu.dk:8443/ws/files/141467395/Profiling_Atlantic_salmon_B_cell_populations.pdf
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7
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges
Autor: Barbara, Piasecka, Darragh, Duffy, Alejandra, Urrutia, Hélène, Quach, Etienne, Patin, Céline, Posseme, Jacob, Bergstedt, Bruno, Charbit, Vincent, Rouilly, Cameron R, MacPherson, Milena, Hasan, Benoit, Albaud, David, Gentien, Jacques, Fellay, Matthew L, Albert, Lluis, Quintana-Murci
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (3), pp.E488-E497. ⟨10.1073/pnas.1714765115⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2018, 115 (3), pp.E488-E497. 〈10.1073/pnas.1714765115〉
Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (3), pp.E488-E497. ⟨10.1073/pnas.1714765115⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 3, pp. E488-E497
Significance Identifying the drivers of the interindividual diversity of the human immune system is crucial to understand their consequences on immune-mediated diseases. By examining the transcriptional responses of 1,000 individuals to various micro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c1d6f3d201b00f9cab14a3eb69ba0bfe
https://hal-pasteur.archives-ouvertes.fr/pasteur-01721850/document
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8
An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
Autor: Liam G. Fearnley, Anni Joensuu, Gad Abraham, Andres Metspalu, Scott C. Ritchie, Johannes Kettunen, Sean G. Byars, Aki S. Havulinna, Markus Perola, Antti J. Kangas, Emma Raitoharju, Olli T. Raitakari, Annika Wennerström, Markus Juonala, Mika Ala-Korpela, Aarno Palotie, Mika Kähönen, Veikko Salomaa, Peter Würtz, Samuli Ripatti, Michael Inouye, Pasi Soininen, Satu Männistö, Artika P. Nath, Lili Milani, Terho Lehtimäki
Publikováno v: Genome Biology, Vol 18, Iss 1, Pp 1-15 (2017)
Genome Biology
Nath, A P, Ritchie, S C, Byars, S G, Fearnley, L G, Havulinna, A S, Joensuu, A, Kangas, A J, Soininen, P, Wennerström, A, Milani, L, Metspalu, A, Männistö, S, Würtz, P, Kettunen, J, Raitoharju, E, Kähönen, M, Juonala, M, Palotie, A, Ala-Korpela, M, Ripatti, S, Lehtimäki, T, Abraham, G, Raitakari, O, Salomaa, V, Perola, M & Inouye, M 2017, ' An interaction map of circulating metabolites, immune gene networks, and their genetic regulation ', Genome Biology, vol. 18, 146 . https://doi.org/10.1186/s13059-017-1279-y
Background Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic control is still lacking. Here
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6baec64e91ae7a1f7205cabd64539d86
http://hdl.handle.net/10138/220542
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9
SAMHD1 Host Restriction Factor: A Link with Innate Immune Sensing of Retrovirus Infection
Autor: John Hiscott, David Olagnier, Rongtuan Lin, Alexandre Sze, Julien van Grevenynghe
Publikováno v: Sze, A, Olagnier, D, Lin, R, van Grevenynghe, J & Hiscott, J 2013, ' SAMHD1 host restriction factor : a link with innate immune sensing of retrovirus infection ', Journal of Molecular Biology, vol. 425, no. 24, pp. 4981-94 . https://doi.org/10.1016/j.jmb.2013.10.022
SAMHD1 [sterile alpha motif and histidine-aspartic domain (HD) containing protein 1] is the most recent addition to a unique group of host restriction factors that limit retroviral replication at distinct stages of the viral life cycle. SAMHD1 is a d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abccd659b637fe0a77a2238a0eb249d
https://doi.org/10.1016/j.jmb.2013.10.022
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10
Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues
Autor: Chien-Sin Chen, Sophia Martina Hergenhan, Alba de Juan, Paul F. Bradfield, Christoph Scheiermann, Michel Aurrand-Lions, David Druzd, Stephan Holtkamp, Robert Pick, Wenyan He, Markus Sperandio, Louise Ince, Jeoffrey Pelletier, Susanne Bierschenk, Jasmin Weber, Julien Martin Pierre Grenier, Kerstin Kraus
Publikováno v: Immunity
Immunity, Elsevier, 2018, 49 (6), pp.1175+. ⟨10.1016/j.immuni.2018.10.007⟩
Immunity, 2018, 49 (6), pp.1175+. ⟨10.1016/j.immuni.2018.10.007⟩
Immunity, Vol. 49, No 6 (2018) pp. 1175-1190.e7
Summary The number of leukocytes present in circulation varies throughout the day, reflecting bone marrow output and emigration from blood into tissues. Using an organism-wide circadian screening approach, we detected oscillations in pro-migratory fa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5312e61d879f4603e0635fb0fbf73a
https://doi.org/10.1016/j.immuni.2018.10.007
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