Výsledky vyhledávání - "Gene Expression Regulation/genetics"

Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia

Autor: Elena Crooks, Sophie M T Wehrens, Hans P. A. Van Dongen, Luigi Venetucci, Shobhan Gaddameedhi, Timothy M. Brown, John S. O’ Neill, Debra J. Skene, Andrew W. Trafford, Edward A. Hayter, Nichola J Barron, David A. Bechtold, Alessandra Stangherlin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Hayter, E A, Wehrens, S M T, Van Dongen, H P A, Stangherlin, A, Gaddameedhi, S, Crooks, E, Barron, N J, Venetucci, L A, Neill, J S O, Brown, T M, Skene, D J, Trafford, A W & Bechtold, D A 2021, ' Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia ', Nature Communications, vol. 12, no. 1, 2472 . https://doi.org/10.1038/s41467-021-22788-8

Electrical activity in the heart exhibits 24-hour rhythmicity, and potentially fatal arrhythmias are more likely to occur at specific times of day. Here, we demonstrate that circadian clocks within the brain and heart set daily rhythms in sinoatrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9799ab86b9df430aa2acc3f981e5e2a
https://doaj.org/article/530c60e952014c1cb2858a92a8c76775

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Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus

Autor: Valentin Schmutz, Nicolas Toni, Mari A. Virtanen, Lucas A. Mongiat, Jan Armida, Matteo Bergami, Laszlo Vutskits, Marine Krzisch, Fred H. Gage, Alejandro F. Schinder, Jacqueline Kocher-Braissant, Silvio Gabriel Temprana, Karl-Klaus Conzelmann, Rudolf Kraftsik

Publikováno v: Brain Structure & Function
Brain structure & function
Brain Structure and Function, vol. 220, no. 4, pp. 2027-2042
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Brain Structure and Function, Vol. 220, No 4 (2015) pp. 2027-2042

The adult dentate gyrus produces new neurons that morphologically and functionally integrate into the hippocampal network. In the adult brain, most excitatory synapses are ensheathed by astrocytic perisynaptic processes that regulate synaptic structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4ce4747eb262a82ec34c49ed41eaac
http://doc.rero.ch/record/331327/files/429_2014_Article_768.pdf

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Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Autor: Mahmoud Elansary, Knut Krohn, Eleonora Porcu, Julia Dmitrieva, Michel Georges, Harm-Jan Westra, Isabel Alves, Matthias Nauck, Jan H. Veldink, Joost Verlouw, Anette Kalnapenkis, Silva Kasela, Alex W. Hewitt, Roy Oelen, Willem H. Ouwehand, Frank Beutner, Ilkka Seppälä, Yukihide Momozawa, Samuli Ripatti, Brenda W.J.H. Penninx, Patrick Deelen, Michael Stumvoll, Jenny van Dongen, Jonathan K. Pritchard, Roman Kreuzhuber, Marie-Julie Favé, Bernett Lee, Hailang Mei, Biao Zeng, Philip Awadalla, Shuang Li, Kate Downes, Gibran Hemani, Urko M. Marigorta, Anke Tönjes, Morris Swertz, Robert Warmerdam, Joseph E. Powell, Mika Kähönen, Urmo Võsa, Brandon L. Pierce, Benjamin P. Fairfax, Anand Kumar Andiappan, Bastiaan T. Heijmans, Martina Müller-Nurasyid, Sven Bergmann, Katharina Schramm, Hanieh Yaghootkar, Sina Rüeger, Monique G. P. van der Wijst, Lude Franke, Ting Qi, Rick Jansen, Greg Gibson, Cisca Wijmenga, Marc Jan Bonder, Yungil Kim, Viktorija Kukushkina, Johannes Kettunen, Joachim Thiery, Peter A C 't Hoen, Zoltán Kutalik, Jian Yang, Dylan H. de Vries, Olaf Rötzschke, Maarten van Iterson, Peter Kovacs, Peter M. Visscher, Wibowo Arindrarto, Oliver Stegle, Natalia Pervjakova, Julian C. Knight, Tõnu Esko, Annique Claringbould, Lili Milani, Patrick F. Sullivan, Habibul Ahsan, Timothy M. Frayling, Lin Tong, Uwe Völker, Reyhan Sönmez Flitman, Eline Slagboom, Dorret I. Boomsma, Holger Prokisch, Michel G. Nivard, Mawusse Agbessi, Joyce B. J. van Meurs, Alexis Battle, Futao Zhang, Emmanouil T. Dermitzakis, Morris A. Swertz, Grant W. Montgomery, Terho Lehtimäki, Coen D.A. Stehouwer, Jaanika Kronberg, Holger Kirsten, Olli T. Raitakari, Sina A. Gharib, Bruce M. Psaty, Seyhan Yazar, Markus Loeffler, Harm Brugge, Jose Alquicira Hernandez, Mark W. Christiansen, Andrew A. Brown, Markus Perola, Markus Scholz, Ashis Saha, Alexander Teumer

Publikováno v: Nature Genetics, 53(9), 1300-1310. Nature Publishing Group
Võsa, U, Jansen, R, Nivard, M G, van Dongen, J, Boomsma, D I, Franke, L, BIOS Consortium & i2QTL Consortium 2021, ' Large-scale cis-and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression ', Nature genetics, vol. 53, no. 9, pp. 1300-1310 . https://doi.org/10.1038/s41588-021-00913-z
Nature Genetics, 53(9), 1300-+. NATURE PORTFOLIO
BIOS Consortium & i2QTL Consortium 2021, ' Large-scale cis-and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression ', Nature Genetics, vol. 53, no. 9, pp. 1300-1310 . https://doi.org/10.1038/s41588-021-00913-z
Nature Genetics
Nature genetics, vol. 53, no. 9, pp. 1300-1310
Nature Genetics, 53, 1300-1310
Nature Genetics, 53, pp. 1300-1310
Nature genetics, 53(9), 1300-1310. Nature Publishing Group

Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b95e9d7b4e1b22eefe3d319e4309b3
https://research.vumc.nl/en/publications/aa2bf4d5-4683-416c-af37-5560d637ebca

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Transcriptional profile of cytokines, regulatory mediators and tlr in mesenchymal stromal cells after inflammatory signaling and cell-passaging

Autor: Robim Marcelino Rodrigues, Makram Merimi, Vera Rogiers, Philippe Lewalle, Laurence Lagneaux, Dhouha Daassi, Rahma Melki, Karolien Buyl, Hassan Fahmi, Mehdi Najar, Joery De Kock, Tamara Vanhaecke

Publikováno v: International journal of molecular sciences, 22 (14
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7309, p 7309 (2021)

Adult human subcutaneous adipose tissue (AT) harbors a rich population of mesenchymal stromal cells (MSCs) that are of interest for tissue repair. For this purpose, it is of utmost importance to determine the response of AT-MSCs to proliferative and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d18997972040e04c455d4d25438cdc
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/329221

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Remodeling of the Caenorhabditis elegans non-coding RNA transcriptome by heat shock

Autor: William P. Schreiner, Jacob M. Garrigues, Jerry S. Chen, Amy E. Pasquinelli, Delaney C Pagliuso, Antti P. Aalto

Publikováno v: Schreiner, W P, Pagliuso, D C, Garrigues, J M, Chen, J S, Aalto, A P & Pasquinelli, A E 2019, ' Remodeling of the Caenorhabditis elegans non-coding RNA transcriptome by heat shock ', Nucleic Acids Research, vol. 47, no. 18, pp. 9829-9841 . https://doi.org/10.1093/nar/gkz693
Nucleic Acids Research

Elevated temperatures activate a heat shock response (HSR) to protect cells from the pathological effects of protein mis-folding, cellular mis-organization, organelle dysfunction and altered membrane fluidity. This response includes activation of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a534a945da38aaace72fdeafe4f49e1
https://doi.org/10.1093/nar/gkz693

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Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants

Autor: Ji-eun Yoon, Arjun Krishnan, Marie Vincent, Marco Fichera, Claire Beneteau, Erik A. Sistermans, Nathalie Marle, Luana Mandarà, Sau Wai Cheung, R. Frank Kooy, Teresa Mattina, Rachel L. Kember, Mathilde Nizon, Jill A. Rosenfeld, Alexandre Reymond, Bertrand Isidor, Sophie Blesson, Jean-Hubert Caberg, Cindy Skinner, Emanuela Avola, Charles Perrine, Paolo Prontera, Susan Zeesman, Małgorzata J.M. Nowaczyk, Kate Pope, Lucilla Pizzo, David J. Amor, Boris Keren, Matthew Jensen, Katrin Männik, Patrick Callier, Pawel Stankiewicz, Damian Pazuchanics, Els Voorhoeve, Ornella Galesi, Joris Andrieux, Lucia Castiglia, Anne Laure Mosca-Boidron, Mathilde Lefebvre, Charles E. Schwartz, Santhosh Girirajan, Elizabeth McCready, Anke Van Dijck, Sandra Mercier, Maja Bucan, Corrado Romano, Laurence Faivre, Francesca Mari, Dominique Martin-Coignard, Vijay Kumar, Alessandra Renieri, Andrew Polyak, Emily Huber, Cédric Le Caignec, Aurora Currò, Olivier Pichon

Publikováno v: Genetics in Medicine
Genetics in Medicine, Nature Publishing Group, In press, ⟨10.1038/s41436-018-0266-3⟩
Genetics in Medicine, 21(4), 816-825. Lippincott Williams and Wilkins
Genetics in medicine : official journal of the American College of Medical Genetics
Genetics in medicine, vol. 21, no. 4, pp. 816-825
Pizzo, L, Jensen, M, Polyak, A, Rosenfeld, J A, Mannik, K, Krishnan, A, McCready, E, Pichon, O, Le Caignec, C, Van Dijck, A, Pope, K, Voorhoeve, E, Yoon, J, Stankiewicz, P, Cheung, S W, Pazuchanics, D, Huber, E, Kumar, V, Kember, R L, Mari, F, Curró, A, Castiglia, L, Galesi, O, Avola, E, Mattina, T, Fichera, M, Mandarà, L, Vincent, M, Nizon, M, Mercier, S, Bénéteau, C, Blesson, S, Martin-Coignard, D, Mosca-Boidron, A L, Caberg, J H, Bucan, M, Zeesman, S, Nowaczyk, M J M, Lefebvre, M, Faivre, L, Callier, P, Skinner, C, Keren, B, Perrine, C, Prontera, P, Marle, N, Renieri, A, Reymond, A, Kooy, R F, Isidor, B, Schwartz, C, Romano, C, Sistermans, E, Amor, D J, Andrieux, J & Girirajan, S 2019, ' Rare variants in the genetic background modulate cognitive and developmental phenotypes in individuals carrying disease-associated variants ', Genetics in Medicine, vol. 21, no. 4, pp. 816-825 . https://doi.org/10.1038/s41436-018-0266-3
Genetics in medicine

Purpose: To assess the contribution of rare variants in the genetic background toward variability of neurodevelopmental phenotypes in individuals with rare copy-number variants (CNVs) and gene-disruptive variants. Methods: We analyzed quantitative cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf6c41b5e591ac3592571ea1af83d4b
http://www.scopus.com/inward/record.url?scp=85053071043&partnerID=8YFLogxK

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tRNA 2'-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila

Publikováno v: Nucleic acids research, vol. 48, no. 4, pp. 2050-2072
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2020, 48 (4), pp.2050-2072. ⟨10.1093/nar/gkaa002⟩
Nucleic Acids Research, Oxford University Press, 2020, ⟨10.1093/nar/gkaa002⟩

2′-O-Methylation (Nm) represents one of the most common RNA modifications. Nm affects RNA structure and function with crucial roles in various RNA-mediated processes ranging from RNA silencing, translation, self versus non-self recognition to viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3016f881fc9b48b02b58bc910d26df8c
https://serval.unil.ch/resource/serval:BIB_54F1E8540412.P001/REF.pdf

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The diverse piscidin repertoire of the european sea bass (Dicentrarchus labrax): Molecular characterization and antimicrobial activities

Autor: Nuno Santarém, Pedro Carvalho, Carolina Barroso, João V. Neves, Carla Carvalho, Pedro Rodrigues, José Gonçalves

Publikováno v: International Journal of Molecular Sciences

Fish rely on their innate immune responses to cope with the challenging aquatic environment, with antimicrobial peptides (AMPs) being one of the first line of defenses. Piscidins are a group of fish specific AMPs isolated in several species. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64477f7515e94e7afdbe96c0f683536c
https://hdl.handle.net/10216/143486

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Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free 'GeneSwitch' vector

Autor: Virginie Zimmer, Sebastian Kügler, Shi Cheng, Frank Streit, Catherine Pythoud, Jolanda M. Liefhebber, Anupam Raina, Pavlina Konstantinova, Nicole Déglon, Maria Rey, Gabriel Vachey, Julia Tereshchenko, Andrzej Mazur, Mathias Bähr

Publikováno v: Experimental neurology, vol. 309, pp. 79-90

Gene therapy is currently an irreversible approach, without possibilities to fine-tune or halt the expression of a therapeutic gene product. Especially when expressing neurotrophic factors to treat neurodegenerative disorders, options to regulate tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6bc910cb868b3ba3bfa0229d4aa882
https://doi.org/10.1016/j.expneurol.2018.07.017

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GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia

Publikováno v: Nature neuroscience. 21(9):1161-1170

Cannabis use is a heritable trait that has been associated with adverse mental health outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to date (N = 184,765), we identified eight genome-wide significant independe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::7ed8f11df23000f14e39e4d9e514674a
https://hdl.handle.net/11370/a53dd95e-9435-4efa-9c24-7933f385ee67

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