Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Gene Expression Regulation/drug effects/physiology"'
Autor:
Patrick Baril, Wissem Deraredj Nadim, Viorel Simion, Chantal Pichon, Hélène Bénédetti, Séverine Morisset-Lopez
Publikováno v:
Current Neuropharmacology
Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.260-275. ⟨10.2174/1570159X14666160709001441⟩
Current Neuropharmacology, Bentham Science Publishers, 2017, 15 (2), pp.260-275. ⟨10.2174/1570159X14666160709001441⟩
International audience; BACKGROUND: Neurodegenerative and cognitive disorders are multifactorial diseases (i.e., involving neurodevelopmental, genetic, age or environmental factors) characterized by an abnormal development that affects neuronal funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266074b2d92f2322e1516a416c0ce2cf
http://europepmc.org/articles/PMC5412695
http://europepmc.org/articles/PMC5412695
Publikováno v:
Diabetes
Fibroblast growth factor 21 (FGF21) stimulates fatty acid oxidation and ketone body production in animals. In this study, we investigated the role of FGF21 in the metabolic activity of sodium butyrate, a dietary histone deacetylase (HDAC) inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6611769b8da3912c3cf406adfaff4de
https://doi.org/10.2337/db11-0846
https://doi.org/10.2337/db11-0846
Autor:
Francesca Frigerio, Søren Fisker Schmidt, Lars la Cour Poulsen, Pierre Maechler, Michael Boergesen, Susanne Mandrup
Publikováno v:
The Journal of biological chemistry
Boergesen, M, Poulsen, L L C, Schmidt, S F, Frigerio, F, Maechler, P & Mandrup, S 2011, ' ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor {alpha} Expression in Pancreatic {beta}-Cells ', Journal of Biological Chemistry, vol. 286, no. 15, pp. 13214-13225 . https://doi.org/10.1074/jbc.M110.215467
Journal of Biological Chemistry, Vol. 286, No 15 (2011) pp. 13214-25
Boergesen, M, Poulsen, L L C, Schmidt, S F, Frigerio, F, Maechler, P & Mandrup, S 2011, ' ChREBP Mediates Glucose Repression of Peroxisome Proliferator-activated Receptor {alpha} Expression in Pancreatic {beta}-Cells ', Journal of Biological Chemistry, vol. 286, no. 15, pp. 13214-13225 . https://doi.org/10.1074/jbc.M110.215467
Journal of Biological Chemistry, Vol. 286, No 15 (2011) pp. 13214-25
Chronic exposure to elevated levels of glucose and fatty acids leads to dysfunction of pancreatic β-cells by mechanisms that are only partly understood. The transcription factor peroxisome proliferator-activated receptor α (PPARα) is an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae9b8a2ff1fd58876384a3edb2c9166
Publikováno v:
The Journal of Pain. 12:13-21
The expression of NF-κB in the spinal cord is associated with neuropathic pain. However, little is known about its expression beyond the spinal cord. Here we examined a spatial and temporal pattern of the NF-κB expression in both spinal and suprasp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289dd755245d5678098686ea401ae822
https://doi.org/10.1016/j.jpain.2010.03.018
https://doi.org/10.1016/j.jpain.2010.03.018
Autor:
Ulrich Schweizer, Nilika Chaudhary, Rubén Nogueiras, Christelle Veyrat-Durebex, Diego Perez-Tilve, Henriette Kirchner, Petra Wiedmer, Eva K. Wirth, Matthias H. Tschöp, Françoise Rohner-Jeanrenaud, Wenke Jonas, Gayathri Ananthakrishnan, Hans-Georg Joost, Annette Schürmann, Chun-Xia Yi, Michaela Rath
Publikováno v:
Physiology & Behavior, Vol. 105, No 3 (2012) pp. 791-9
Physiology & behavior, 105(3), 791-799. Elsevier Inc.
Physiology & behavior
Physiology & behavior, 105(3), 791-799. Elsevier Inc.
Physiology & behavior
The central melanocortin system regulates lipid metabolism in peripheral tissues such as white adipose tissue. Alterations in the activity of sympathetic nerves connecting hypothalamic cells expressing melanocortin 3/4 receptors (MC3/4R) with white a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33dc96bbb0e0b0cc86fd31bb048aa10d
https://archive-ouverte.unige.ch/unige:26312
https://archive-ouverte.unige.ch/unige:26312
Autor:
Tanioka, Toshihiro, Tamura, Yoshiaki, Fukaya, Makiko, Shinozaki, Shohei, Mao, Ji, Kim, Minhye, Shimizu, Nobuyuki, Kitamura, Tadahiro, Kaneki, Masao
Publikováno v:
The Journal of biological chemistry, 286 (33
Insulin receptor substrate-2 (IRS-2) plays a critical role in the survival and function of pancreatic β-cells. Gene disruption of IRS-2 results in failure of the β-cell compensatory mechanism and diabetes. Nonetheless, the regulation of IRS-2 prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2101::5cd6bd8df62b7b298fb07b06ab18b32b
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/136991
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/136991
Autor:
Fabrice Moore, Decio L. Eizirik, Daniel J. Drucker, Piero Marchetti, Adriano Maida, Esteban Nicolas Gurzov, Gabriel Núñez, Conny Gysemans, Jenny Barthson, Chantal Mathieu, Andrea Jurisicova, Carla Maria Ramos C.M. Germano
Publikováno v:
The Journal of biological chemistry, 286 (45
Type 1 diabetes is characterized by local inflammation (insulitis) in the pancreatic islets causing β-cell loss. The mitochondrial pathway of apoptosis is regulated by the balance and interaction between Bcl-2 members. Here we clarify the molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c53c0bfde60f0758e042a5093bd6a4
http://hdl.handle.net/11568/148517
http://hdl.handle.net/11568/148517
Publikováno v:
Neurology, Vol. 76, No 8 Suppl 3 (2011) pp. S15-9
Neurology
Neurology
Viral infections may have an important role in the precipitation or relapse of multiple sclerosis (MS) and its treatment. This review describes the normal immune response to viral infection, the possible associations between viral infections and MS t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4d03319fb97304a8e6a4245fb72ca9
https://archive-ouverte.unige.ch/unige:24933
https://archive-ouverte.unige.ch/unige:24933
Autor:
Leuba, Genevieve, Walzer, Claude, Vernay, Andre, Carnal, Beatrice, Kraftsik, Rudolf, Piotton, Françoise, Marin, Pascale, Bouras, Constantin, Savioz, Armand
Publikováno v:
Neurobiology of Disease, Vol. 30, No 3 (2008) pp. 408-419
In order to understand how plasticity is related to neurodegeneration, we studied synaptic proteins with quantitative immunohistochemistry in the entorhinal cortex from Alzheimer patients and age-matched controls. We observed a significant decrease i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1400::32c1284cbb00047cf41837d8f8ca597c
https://archive-ouverte.unige.ch/unige:19185
https://archive-ouverte.unige.ch/unige:19185
Autor:
Murdoch, H., Mackie, S., Collins, D. M., Hill, E. V., Bolger, G. B., Klussmann, E., Porteous, D. J., Millar, J. K., Houslay, M. D.
Publikováno v:
Murdoch, H, Mackie, S, Collins, D M, Hill, E V, Bolger, G B, Klussmann, E, Porteous, D J, Millar, J K & Houslay, M D 2007, ' Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels ', Journal of Neuroscience, vol. 27, no. 35, pp. 9513-9524 . < http://www.jneurosci.org/content/27/35/9513.full.pdf >
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::aefb6e6574ae0832ca91392db3d67d88
https://eprints.gla.ac.uk/4143/1/Murdoch4143.pdf
https://eprints.gla.ac.uk/4143/1/Murdoch4143.pdf