Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Gene Expression Regulation/*drug effects/genetics"'
1
Erythropoietin reduces experimental autoimmune encephalomyelitis severity via neuroprotective mechanisms
Autor: M. Bednar, Omolara O. Ogunshola, M. Moransard, Max Gassmann, K. Frei
Publikováno v: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-13 (2017)
Background Treatment with erythropoietin (Epo) in experimental autoimmune encephalomyelitis (EAE), the rodent model of multiple sclerosis (MS), has consistently been shown to ameliorate disease progression and improve overall outcome. The effect has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59a7ca3377fc2b6862252dfe1c72b76
https://pubmed.ncbi.nlm.nih.gov/29029628
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2
Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection*
Autor: Johannes Roth, Yvonne Börgeling, Carolin Nordhoff, Mirco Schmolke, Dorothee Viemann, Stephan Ludwig
Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry, Vol. 289, No 1 (2014) pp. 13-27
Background: Early cytokine dysregulation upon infection with highly pathogenic avian influenza viruses (HPAIV) is a major determinant of viral pathogenicity. Results: p38 MAPK controls HPAIV-induced gene expression by regulating interferon synthesis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4959712dd5724faba43ebc04f21f8bab
http://europepmc.org/articles/PMC3879537
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4
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor
Autor: Adolfo García-Sastre, Shuguang Wei, Michael G. Roth, James Brugarolas, Gijs A. Versteeg, Mirco Schmolke, Michael A. White, Doug E. Frantz, Noelle S. Williams, Miguel A. Mata, Beatriz M. A. Fontoura, Neal Satterly, Samuel Peña-Llopis, Christian V. Forst
Publikováno v: Nature Chemical Biology, Vol. 7, No 10 (2011) pp. 712-719
A chemical genetics approach was taken to identify inhibitors of NS1, a major influenza A virus virulence factor that inhibits host gene expression. A high-throughput screen of 200,000 synthetic compounds identified small molecules that reversed NS1-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d7107c92edc2bb3182345946c9cb6b
https://archive-ouverte.unige.ch/unige:75396
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5
Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment
Autor: Rafael Franco, Romano La Harpe, Leyre Urigüen, M. Julia García-Fuster, Carmen Lluis, Luis F. Callado, Benito Morentin, Vicent Casadó, J. Javier Meana, Jesús A. García-Sevilla
Publikováno v: Psychopharmacology, Vol. 206, No 2 (2009) pp. 313-24
RATIONALE: Dopamine D2 receptors are the main target of antipsychotic drugs. In the brain, D2 receptors coexpress with adenosine A2A and CB1 cannabinoid receptors, leading to functional interactions. OBJECTIVES: The protein and messenger RNA (mRNA) c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdb7c7293046e8b223a20c670c3b4d9
https://pubmed.ncbi.nlm.nih.gov/19652957
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6
Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant
Autor: Marco Prinz, Florian Klinker, Wolfgang Brück, Doron Merkler, Hauke Schmidt, Jenni Raasch, Sandra Krauss
Publikováno v: Experimental Neurology, Vol. 216, No 2 (2009) pp. 306-311
The type I interferons, interferon-beta and alpha (IFN-beta, IFN-alpha), are widely used for the treatment of autoimmune demyelination in the central nervous system (CNS). Their effects on de- and remyelination through the broadly expressed type I IF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd66e4f904e608a8fe49eb4d8059101
https://pubmed.ncbi.nlm.nih.gov/19121307
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7
Lysobisphosphatidic acid controls endosomal cholesterol levels
Autor: Guowei Jiang, Stefan Matile, Robert G. Parton, Glenn D. Prestwich, Jean Gruenberg, Julien Chevallier, Zeina Chamoun, Naomi Sakai
Publikováno v: Journal of Biological Chemistry, Vol. 283, No 41 (2008) pp. 27871-27880
ResearcherID
Most cell types acquire cholesterol by endocytosis of circulating low density lipoprotein, but little is known about the mechanisms of intra-endosomal cholesterol transport and about the primary cause of its aberrant accumulation in the cholesterol s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb81bdc19c1069d36364f24299b10c0d
https://pubmed.ncbi.nlm.nih.gov/18644787
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8
Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer
Autor: Xin Chen, Jennifer M. Halbleib, W. James Nelson, Siu Tsan Yuen, Patrick O. Brown, Suet Yi Leung, Annika M. Sääf
Posttranslational mechanisms are implicated in the development of epithelial cell polarity, but little is known about the patterns of gene expression and transcriptional regulation during this process. We characterized temporal patterns of gene expre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d0e0f64fd66892663ca5b95d4fbeda0
http://hdl.handle.net/10722/57152
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9
HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes
Autor: Didier Trono, Lei Wan, Gary Thomas, Aram Mangasarian, Christelle Borel, Vincent Piguet, Nicolas Demaurex
Publikováno v: Nature Cell Biology, Vol. 2, No 3 (2000) pp. 163-7
Major-histocompatibility-complex (MHC) proteins are used to display, on the surface of a cell, peptides derived from foreign material — such as a virus — that is infecting that cell. Cytotoxic T lymphocytes then recognize and kill the infected ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e164cbc5ed87d3b91bdf532d1c8b320
https://archive-ouverte.unige.ch/unige:30339
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