APOBEC3C, a nucleolar protein induced by genotoxins, is excluded from DNA damage sites

Autor: María del Carmen Conde-Rubio, Gilles Dubuis, Christian Widmann, Daniel Constantin

Publikováno v: The FEBS journal, vol. 289, no. 3, pp. 808-831

The human genome contains 11 APOBEC (apolipoprotein B mRNA editing catalytic polypeptide-like) cytidine deaminases classified into four families. These proteins function mainly in innate antiviral immunity and can also restrict endogenous retrotransp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed082bf9274bb2db8cd80d43f41b48dc
https://serval.unil.ch/notice/serval:BIB_549304C0D4F3

Insects are a viable protein source for human consumption: from insect protein digestion to postprandial muscle protein synthesis in vivo in humans: a double-blind randomized trial

Autor: Cas J. Fuchs, Tyler A. Churchward-Venne, Joey S J Smeets, Kevin J M Paulussen, Lex B. Verdijk, Joan M. G. Senden, Luc J. C. van Loon, Wesley J H Hermans, Joop J. A. van Loon

Publikováno v: American Journal of Clinical Nutrition, 114(3), 934-944. Oxford University Press
The American journal of clinical nutrition 114 (2021) 3
The American journal of clinical nutrition, 114(3), 934-944

Background Insects have recently been identified as a more sustainable protein-dense food source and may represent a viable alternative to conventional animal-derived proteins. Objectives We aimed to compare the impacts of ingesting lesser mealworm�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452ac9136b62c4c7cc7da9dbb91f22be
https://cris.maastrichtuniversity.nl/en/publications/0637ee11-f2e4-4766-8536-510b422d6078

Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial

Autor: Davide Susta, Ricardo Segurado, Kathleen A. J. Mitchelson, Joan M. G. Senden, Caoileann H. Murphy, Giuseppe De Vito, Ellen M Flanagan, Sinead McCarthy, Brendan Egan, Joy P B Goessens, Adrian Chabowski, Luc J. C. van Loon, Clare A. Corish, Helen M. Roche, Elena de Marco Castro, Agnieszka Mikłosz

Publikováno v: Murphy, C H, Flanagan, E M, De Vito, G, Susta, D, Mitchelson, K A J, de Marco Castro, E, Senden, J M G, Goessens, J P B, Mikłosz, A, Chabowski, A, Segurado, R, Corish, C A, McCarthy, S N, Egan, B, van Loon, L J C & Roche, H M 2021, ' Does supplementation with leucine-enriched protein alone and in combination with fish-oil-derived n-3 PUFA affect muscle mass, strength, physical performance, and muscle protein synthesis in well-nourished older adults? A randomized, double-blind, placebo-controlled trial ', The American journal of clinical nutrition, vol. 113, no. 6, pp. 1411–1427 . https://doi.org/10.1093/ajcn/nqaa449
American Journal of Clinical Nutrition, 113(6), 1411-1427. Oxford University Press
The American Journal of Clinical Nutrition

Background: Leucine-enriched protein (LEU-PRO) and long-chain(LC) n–3 (ω–3) PUFAs have each been proposed to improve muscle mass and function in older adults, whereas their combination may be more effective than either alone.Objective: The impac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6972176484f30c57816edd1eba28f8d4
https://pure.qub.ac.uk/en/publications/does-supplementation-with-leucineenriched-protein-alone-and-in-combination-with-fishoilderived-n3-pufa-affect-muscle-mass-strength-physical-performance-and-muscle-protein-synthesis-in-wellnourished-older-adults-a-randomized-doubleblind-placebocontrolled-trial(420da3a1-f13f-44cd-a354-accb2c34e334).html

TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity

Autor: Mário A. Barbosa, Teresa Summavielle, Susana G. Santos, Jaime Freitas, Joana Bravo, Maria Inês Almeida, Joao Paulo Bras

Publikováno v: Cell Death and Disease, Vol 11, Iss 6, Pp 1-15 (2020)
Cell Death & Disease
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Growing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders. In some pathological conditions, microglia produce inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401f63fb9a756b8fd8925ca8ee30868b
https://doi.org/10.1038/s41419-020-2626-6

Therapeutic efficacy of regulable GDNF expression for Huntington's and Parkinson's disease by a high-induction, background-free 'GeneSwitch' vector

Autor: Virginie Zimmer, Sebastian Kügler, Shi Cheng, Frank Streit, Catherine Pythoud, Jolanda M. Liefhebber, Anupam Raina, Pavlina Konstantinova, Nicole Déglon, Maria Rey, Gabriel Vachey, Julia Tereshchenko, Andrzej Mazur, Mathias Bähr

Publikováno v: Experimental neurology, vol. 309, pp. 79-90

Gene therapy is currently an irreversible approach, without possibilities to fine-tune or halt the expression of a therapeutic gene product. Especially when expressing neurotrophic factors to treat neurodegenerative disorders, options to regulate tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6bc910cb868b3ba3bfa0229d4aa882
https://doi.org/10.1016/j.expneurol.2018.07.017