Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study

Autor: Ulla Kampmann, Janne R. Hingst, Niels Jessen, Jørgen F. P. Wojtaszewski, Mads Svart, Niels Møller, Thomas Schmidt Voss, Mikkel H. Vendelbo

Publikováno v: Voss, T S, Vendelbo, M, Opstrup, U K, Hingst, J R, Wojtaszewski, J F P, Svart, M, Møller, N & Jessen, N 2017, ' Acute Hypoglycemia in Healthy Humans Impairs Insulin Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle; a Randomized Clinical Study ', Diabetes, vol. 66, no. 9, pp. 2483-2494 . https://doi.org/10.2337/db16-1559

Hypoglycemia is the leading limiting factor in glycemic management of insulin-treated diabetes. Skeletal muscle is the predominant site of insulin-mediated glucose disposal. Our study used a crossover design to test to what extent insulin-induced hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b27ddeca9d3fd63a619eb4e9fe63b84
https://doi.org/10.2337/db16-1559

Anti-remodeling effects of xanthohumol-fortified beer in pulmonary arterial hypertension mediated by ERK and AKT inhibition

Autor: Rita Negrão, Ana Filipa Silva, Daniel Moreira-Gonçalves, Tiago Henriques-Coelho, Ilda Rodrigues, Manuel Filipe Santos, Gabriel Faria-Costa, Adelino F. Leite-Moreira, João Tiago Guimarães, Fábio Sousa-Nunes, Manuel J. Ferreira-Pinto, Delfim Duarte

Publikováno v: Nutrients
Volume 11
Issue 3
Nutrients, Vol 11, Iss 3, p 583 (2019)

Polyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da8f5dc9731a19fb5124d569ae143998
https://hdl.handle.net/10216/136302

Pantoprazole increases cell viability and function of primary human osteoblasts in vitro

Autor: Claudine Seeliger, Martijn van Griensven, Alexander T. Haug, Marina Unger, Markus Prause

Publikováno v: Injury-International Journal of the Care of the Injured, 45(8), 1156-64. ELSEVIER SCI LTD

Proton pump inhibitors (PPIs) are a class of drugs that irreversibly inhibit the H(+)/K(+)-ATPase in gastric parietal cells. Since an association between PPI use and increased fracture risk has been found, the aim of this study was to detect potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb885ed791c07fc2502c83abc34e48d
https://doi.org/10.1016/j.injury.2014.05.005

Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids

Autor: Karim Raza, A Filer, Elizabeth H. Rabbitt, Martin Hewison, J.P.T.M. van Leeuwen, Rowan Hardy, Mark S. Cooper, Antonis Thomas, Paul M. Stewart, K Kaur, Marco Eijken, Mohammad Mainul Ahasan, Christopher D. Buckley

Publikováno v: Annals of the rheumatic diseases, vol 69, iss 6
Annals of the Rheumatic Diseases, 69(6), 1185-1190. BMJ Publishing Group
Kaur, K, Hardy, R, Ahasan, M M, Eijken, M, van Leeuwen, J P, Filer, A, Thomas, A M, Raza, K, Buckley, C D, Stewart, P M, Rabbitt, E H, Hewison, M & Cooper, M S 2010, ' Synergistic induction of local glucocorticoid generation by inflammatory cytokines and glucocorticoids : implications for inflammation associated bone loss ', Annals of the Rheumatic Diseases, vol. 69, no. 6, pp. 1185-90 . https://doi.org/10.1136/ard.2009.107466
Annals of the Rheumatic Diseases

ObjectivesSynovial fibroblasts and osteoblasts generate active glucocorticoids by means of the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme. This activity increases in response to proinflammatory cytokines or glucocorticoids. During in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388a01dbd34860c720e63aa17876c1a4
https://hdl.handle.net/1765/20327

Effects of choline-deprivation on paracetamol- or phenobarbital-induced rat liver metabolic response

Autor: Apostolos Zarros, Stamatios Theocharis, Panagiota Galanopoulou, Dimitrios Segos, Maria Konstandi, Charis Liapi, Marios Marselos, Matti A. Lang

Publikováno v: Journal of Applied Toxicology. 29:101-109

Choline is an essential nutrient that seems to be involved in a wide variety of metabolic reactions and functions in both humans and rodents. Various pathophysiological states have been linked to choline deprivation (CD). The aim of the present study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b97dd08025883594307fb89c0a92995
https://doi.org/10.1002/jat.1386