Výsledky vyhledávání - "Gene Expression/drug effects/genetics"

TRIB3 [corrected] is implicated in glucotoxicity- and endoplasmic reticulum-stress-induced [corrected] beta-cell apoptosis

Autor: Bo, Qian, Haiyan, Wang, Xiuli, Men, Wenjian, Zhang, Hanqing, Cai, Shiqing, Xu, Yaping, Xu, Liya, Ye, Claes B, Wollheim, Jinning, Lou

Publikováno v: Journal of Endocrinology, Vol. 199, No 3 (2008) pp. 407-416

We found that TRIB3, [corrected] an endogenous inhibitor of Akt (PKB), is expressed in pancreatic beta-cells. The TRIB3 [corrected] expression is significantly increased in islets isolated from hyperglycemic Goto-Kakizaki rats compared with normal gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::26396b8c4b2eb02c4943d54bd81c3c77
https://archive-ouverte.unige.ch/unige:19135

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Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells

Autor: P. A. Antinozzi, Claes B. Wollheim, M. Iezzi, Sten Theander, Haiyan Wang, Philippe A. Halban, Benoit R. Gauthier

Publikováno v: Diabetologia, Vol. 48, No 4 (2005) pp. 720-731

AIMS/HYPOTHESIS: Mutations in genes encoding HNF-4alpha, HNF-1alpha and IPF-1/Pdx-1 are associated with, respectively, MODY subtypes-1, -3 and -4. Impaired glucose-stimulated insulin secretion is the common primary defect of these monogenic forms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6bd1978dd017d84ef211fd5a0484893
https://pubmed.ncbi.nlm.nih.gov/15756539

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