Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Gene Cutler"'
Autor:
Aparna Jorapur, Lisa A Marshall, Scott Jacobson, Mengshu Xu, Sachie Marubayashi, Mikhail Zibinsky, Dennis X Hu, Omar Robles, Jeffrey J Jackson, Valentin Baloche, Pierre Busson, David Wustrow, Dirk G Brockstedt, Oezcan Talay, Paul D Kassner, Gene Cutler
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1010200 (2022)
The Epstein-Barr Virus (EBV) is involved in the etiology of multiple hematologic and epithelial human cancers. EBV+ tumors employ multiple immune escape mechanisms, including the recruitment of immunosuppressive regulatory T cells (Treg). Here, we sh
Externí odkaz:
https://doaj.org/article/4d16e0321b6e41c7ae448e91efe27eef
Autor:
Brian Wong, Dirk G Brockstedt, Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, Omar Robles, Dennis Xiaozhou Hu, Jeffrey J Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, Angela Wadsworth, David Chian, David Wustrow, Paul D Kassner, Gene Cutler, Oezcan Talay
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Checkpoint inhibitors (CPIs) such as anti-PD(L)-1 and anti-CTLA-4 antibodies have resulted in unprecedented rates of antitumor responses and extension of survival of patients with a variety of cancers. But some patients fail to respond or
Externí odkaz:
https://doaj.org/article/3beb97b17518498284642adadb08fbeb
Autor:
Roy Blum, Rashmi Gupta, Patricia E Burger, Christopher S Ontiveros, Sarah N Salm, Xiaozhong Xiong, Alexander Kamb, Holger Wesche, Lisa Marshall, Gene Cutler, Xiangyun Wang, Jiri Zavadil, David Moscatelli, E Lynette Wilson
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Signals between stem cells and stroma are important in establishing the stem cell niche. However, very little is known about the regulation of any mammalian stem cell niche as pure isolates of stem cells and their adjacent mesenchyme are not readily
Externí odkaz:
https://doaj.org/article/edc2e4d8f0b5421992293e7bdc8e072e
Autor:
Roy Blum, Rashmi Gupta, Patricia E Burger, Christopher S Ontiveros, Sarah N Salm, Xiaozhong Xiong, Alexander Kamb, Holger Wesche, Lisa Marshall, Gene Cutler, Xiangyun Wang, Jiri Zavadil, David Moscatelli, E Lynette Wilson
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5722 (2009)
BACKGROUND:The global gene expression profiles of adult and fetal murine prostate stem cells were determined to define common and unique regulators whose misexpression might play a role in the development of prostate cancer. METHODOLOGY/PRINCIPAL FIN
Externí odkaz:
https://doaj.org/article/9ee26821c0a342a0927e05c63688aeea
Autor:
Jeffrey J. Jackson, Grant M. Shibuya, Buvana Ravishankar, Lavanya Adusumilli, Delia Bradford, Dirk G. Brockstedt, Cyril Bucher, Minna Bui, Cynthia Cho, Christoph Colas, Gene Cutler, Adrian Dukes, Xinping Han, Dennis X. Hu, Scott Jacobson, Paul D. Kassner, George E. Katibah, Michelle Yoo Min Ko, Urvi Kolhatkar, Paul R. Leger, Anqi Ma, Lisa Marshall, Jack Maung, Andrew A. Ng, Akinori Okano, Deepa Pookot, Daniel Poon, Chandru Ramana, Maureen K. Reilly, Omar Robles, Jacob B. Schwarz, Anton A. Shakhmin, Hunter P. Shunatona, Raashi Sreenivasan, Parcharee Tivitmahaisoon, Mengshu Xu, Thant Zaw, David J. Wustrow, Mikhail Zibinsky
Publikováno v:
Journal of Medicinal Chemistry. 65:12895-12924
General control nonderepressible 2 (GCN2) protein kinase is a cellular stress sensor within the tumor microenvironment (TME), whose signaling cascade has been proposed to contribute to immune escape in tumors. Herein, we report the discovery of cell-
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
Genes whose expression is significantly altered upon USP7 inhibitor treatment of H526 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f989ee2cc8256a47675f17613ed482
https://doi.org/10.1158/1535-7163.22518810
https://doi.org/10.1158/1535-7163.22518810
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2553fdd80c98dcbf6dde06a2115d9b1f
https://doi.org/10.1158/1535-7163.c.6542127.v1
https://doi.org/10.1158/1535-7163.c.6542127.v1
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
Supplementary Figures S1-S6 and legends, and Tables S1, S2, S5, S6, S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608a87c8b9624888e8b1c3a5ac3f572b
https://doi.org/10.1158/1535-7163.22518816.v1
https://doi.org/10.1158/1535-7163.22518816.v1
Autor:
Jacob Bradley Schwarz, Christophe Colas, Paul D. Kassner, Betty Abraham, Delia Bradford, Michael T. Sun, Lisa A. Marshall, Akinori Okano, Dennis X. Hu, Gene Cutler, Payal Rana, Paul Leger, David J. Wustrow, Cynthia Cho, Jack Maung, Yamini M. Ohol, Deepa Pookot, Nathan Kozon, Steve Wong, Scott Jacobson, Niket Shah, Berenger Biannic, Xinping Han, Silpa Suthram, Jerick Sanchez, Dirk G. Brockstedt, Kyle Young
Publikováno v:
Molecular Cancer Therapeutics. 19:1970-1980
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging age
Autor:
Scott Jacobson, Dennis X. Hu, Cesar Meleza, Mikhail Zibinsky, Ashkaan Younai, Erin Riegler, Omar Robles, Jenny McKinnell, Emily Karbarz, Paul D. Kassner, Lisa A. Marshall, Maureen Kay Reilly, David Chian, Gene Cutler, David J. Wustrow, Dirk G. Brockstedt, Hunter P. Shunatona, Raymond Diokno, Angela Wadsworth, John M. Ketcham, Oezcan Talay, Jeffrey J. Jackson
Publikováno v:
Journal of Medicinal Chemistry. 63:8584-8607
The C-C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (Treg) as well as other circulating and tissue-resident T cells. Treg can be recruited to the tumor microenvironment (TME) through the C-C chemokines CCL17 and CCL22. Treg