Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gene C. Webb"'
Publikováno v:
Islets, 2(5), 308-317. Taylor & Francis Group
Pancreatic beta-cell response to glucose stimulation is governed by tightly regulated signaling pathways which have not been fully characterized. A screen for novel signaling intermediates identified Pim3 as a glucose-responsive gene in the beta-cell
Publikováno v:
Diabetes. 56:2744-2752
OBJECTIVE—Glucagon, which raises blood glucose levels by stimulating hepatic glucose production, is produced in α-cells via cleavage of proglucagon by prohormone convertase (PC)-2. In the enteroendocrine L-cell, proglucagon is differentially proce
Publikováno v:
Nature Clinical Practice Endocrinology & Metabolism. 3:594-605
For microarrays, the transition from research to clinical and diagnostic applications is well underway. Microarrays use a range of specific probes that are immobilized in known locations on a support matrix; this technique can measure levels of speci
Autor:
Nina Ågren, Lingge Lu, Ingrid Nilsson, Gene C. Webb, Cheryl A. Roe, Charlotte Rolny, Michael Welsh
Publikováno v:
Experimental Cell Research. 308:381-393
The mechanisms controlling blood vessel formation during early embryonal development have only partly been elucidated. Shb is an adaptor protein previously implicated in the angiogenic response to vascular endothelial growth factor (VEGF). To elucida
Publikováno v:
Diabetes. 51:398-405
Prohormone convertase 2 (PC2) plays an essential role in the processing of proglucagon to mature active glucagon in pancreatic alpha-cells (J Biol Chem 276:27197-27202, 2001). Mice lacking PC2 demonstrate multiple defects, including chronic mild hypo
Autor:
Machi Furuta, An Zhou, Donald F. Steiner, Mariella Ravazzola, Lelio Orci, Gene C. Webb, Raymond J. Carroll
Publikováno v:
Journal of Biological Chemistry. 276:27197-27202
Mice homozygous for a deletion in the gene encoding prohormone convertase 2 (PC2) are generally healthy but have mild hypoglycemia and flat glucose-tolerance curves. Their islets show marked alpha (A)-cell hyperplasia, suggesting a possible defect in
Publikováno v:
Proceedings of the National Academy of Sciences. 97:5773-5778
Pancreatic beta cells respond to changes in blood glucose by secreting insulin and increasing insulin synthesis. To identify genes used in these responses, we have carried out expression profiling of beta cells exposed to high (25 mM) or low (5.5 mM)
Publikováno v:
Genetics. 147:467-478
The PEP7 gene from Saccharomyces cerevisiae encodes a 59-kD hydrophilic polypeptide that is required for transport of soluble vacuolar hydrolase precursors from the TGN to the endosome. This study presents the results of a high-copy suppression analy
Type 2 diabetes (T2D) is characterized by elevated blood glucose levels owing to insufficient secretion and/or activity of the glucose-lowering hormone insulin. Glucagon-like peptide-1 (GLP-1) has received much attention as a new treatment for diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364c7558bd22b57e3462acb61fe8fb65
https://europepmc.org/articles/PMC2834990/
https://europepmc.org/articles/PMC2834990/
Publikováno v:
The Journal of biological chemistry. 279(30)
The endoproteolytic processing of proproteins in the secretory pathway depends on the expression of selected members of a family of subtilisin-like endoproteases known as the prohormone convertases (PCs). The main PC family members expressed in mamma