Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Gene C. Palmer"'
Autor:
Kenneth I. Maynard, Gene C. Palmer, Saran Jonas, Roland N. Auer, Toshio Narahashi, Moussa B.H. Youdim, Bruce Trembly, William Slikker, Kathryn M. Carbone
Publikováno v:
Annals of the New York Academy of Sciences. 939:465-477
Publikováno v:
Annals of the New York Academy of Sciences. 939:283-296
The intraluminal suture model of transient middle cerebral artery occlusion (MCAO) in the Sprague Dawley strain of rats characteristically results in an inconsistently sized brain lesion. The purpose of the investigation reported here was to determin
Autor:
Gene C. Palmer
Publikováno v:
Current Drug Targets. 2:241-271
Because of adverse reactions, early efforts to introduce high affinity competitive or use-dependent NMDA receptor antagonists into patients suffering from stroke, head trauma or epilepsy met with failure. Later it was discovered that both low affinit
Autor:
Gene C. Palmer, P Bialobok, P Gendron, Dan Widzowski, Simon Sydserff, Thomas J. Hudzik, Dale Corbett, A. R. Borrelli, J Miller, A Howell
Publikováno v:
Pharmacology Biochemistry and Behavior. 65:553-562
The purpose of the present study was to assess the magnitude and stability of a number of functional deficits in rats subjected to occlusion of the middle cerebral artery (MCAO). Three groups of rats, treated with 90-min, 120-min, or sham occlusion w
Publikováno v:
Brain Research. 813:191-194
It is hypothesized that after various types of brain injury, blood–brain barrier (BBB) opening and vasogenic edema result from excessive neuronal release of glutamate and stimulation of capillary N-methyl- d -aspartate (NMDA) receptors linked to po
Acute heat stress model of seizures in weanling rats: Influence of prototypic anti-seizure compounds
Publikováno v:
Epilepsy Research. 30:203-217
The present study tested the therapeutic potential for prototype anti-epilepsy drugs using an animal model of infantile febrile seizures. The model consisted of immersion of weanling rats (21 days old) in a 45°C water bath for a maximum of 4 min (fo
Publikováno v:
Epilepsia. 37:544-550
Summary: This study was designed to determine the possible abuse liability and phencyclidine-like effects of the low-affinity uncompetitive N-methyla-aspartate (NMDA) antagonists remacemide hydrochloride [(+min)-2–amino-N-(1 -methyl-1,2–diphenyle
Autor:
Gene C. Palmer, Thomas J. Hudzik
Publikováno v:
Epilepsy Research. 21:183-193
One of the primary undesired effects of anticonvulsant medication is an impairment in cognitive function, such as new learning ability. The purpose of the present study was to compare the effects of remacemide hydrochloride [(±)-2-amino- N -(1-methy
Publikováno v:
Life Sciences. 54:PL271-PL275
Seizures may be induced in mice in response to stimulation of glutamate receptors by kainic acid or inhibition of certain voltage-dependent potassium channels by 4-aminopyridine (4-AP). The anti-seizure efficacy of intraperitoneally administered anti
Autor:
Louis R. Freedman, H. Steve White, Ranjit Ray, James C. Blosser, Sally A. McCreedy, Gene C. Palmer, George E. Garske, Ronald C. Griffith, Jose H. Woodhead, Eric W. Harris, Ewart A. Swinyard, Napier James J
Publikováno v:
Epilepsy Research. 9:161-174
Studies conducted by Fisons Pharmaceuticals and the Antiepileptic Drug Development Program (ADD Program) of the Epilepsy Branch (NINDS, NIH) revealed that ‘remacemide’ (FPL 12924, formerly PR 934-423) was effective orally in the prevention of max