Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Gene B, Hubbard"'
Autor:
Kai Mao, Gabriela Farias Quipildor, Tahmineh Tabrizian, Ardijana Novaj, Fangxia Guan, Ryan O. Walters, Fabien Delahaye, Gene B. Hubbard, Yuji Ikeno, Keisuke Ejima, Peng Li, David B. Allison, Hossein Salimi-Moosavi, Pedro J. Beltran, Pinchas Cohen, Nir Barzilai, Derek M. Huffman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Reduced IGF-1 signaling increases longevity in many organisms. Here, Mao et al. show that administration of an anti-IGF-1R antibody is well tolerated and delays aging in female mice; importantly, late-life targeting is sufficient to achieve the benef
Externí odkaz:
https://doaj.org/article/6c2da7569db9463080f4475bda1b2e80
Autor:
Danielle Marquete Vitelli-Avelar, Renato Sathler-Avelar, Armanda Moreira Mattoso-Barbosa, Nicolas Gouin, Marcelo Perdigão-de-Oliveira, Leydiane Valério-Dos-Reis, Ronaldo Peres Costa, Silvana Maria Elói-Santos, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Edward J Dick, Gene B Hubbard, Jane F VandeBerg, John L VandeBerg
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005233 (2017)
BACKGROUND:Non-human primates have been shown to be useful models for Chagas disease. We previously reported that natural T. cruzi infection of cynomolgus macaques triggers clinical features and immunophenotypic changes of peripheral blood leukocytes
Externí odkaz:
https://doaj.org/article/9d9a14bc324d4c0cbcf9891c3d0bb193
Autor:
Renato Sathler-Avelar, Danielle Marquete Vitelli-Avelar, Armanda Moreira Mattoso-Barbosa, Marcelo Perdigão-de-Oliveira, Ronaldo Peres Costa, Silvana Maria Elói-Santos, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Edward J Dick, Gene B Hubbard, Jane F VandeBerg, John L VandeBerg
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004302 (2016)
BACKGROUND:Cynomolgus macaques (Macaca fascicularis) represent a feasible model for research on Chagas disease since natural T. cruzi infection in these primates leads to clinical outcomes similar to those observed in humans. However, it is still unk
Externí odkaz:
https://doaj.org/article/2f39a4f99ec84abb97acc06341a4bbf0
Autor:
Yuji Ikeno, Madeline G. Roman, Colton Allen, Gene B. Hubbard, Geneva M. Cunningham, Lisa C. Flores, Christie Cheng, Yidong Bai
Publikováno v:
Aging Pathobiology and Therapeutics. 2:203-209
Background: This study was conducted to test the effects of thioredoxin (Trx)1 down-regulation in Trx2 transgenic [Tg(TXN2) +/0] mice on lifespan and age-related diseases. Our previous study with Tg(TXN2) +/0 mice showed that mitochondrial Trx overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aba31b3c49d1ded4bc5b7a0842c89b65
https://doi.org/10.31491/apt.2020.12.041
https://doi.org/10.31491/apt.2020.12.041
Autor:
Madeline G, Roman, Lisa C, Flores, Geneva M, Cunningham, Christie, Cheng, Sara, Dube, Colton, Allen, Holly, Van Remmen, Yidong, Bai, Gene B, Hubbard, Thomas L, Saunders, Yuji, Ikeno
Publikováno v:
Aging Pathobiology and Therapeutics. 2:20-31
Objective: In this study, the effects of overexpression of thioredoxin 2 (Trx2) on aging and age-related diseases were examined using Trx2 transgenic mice [Tg(TXN2)+/0]. Because our previous studies demonstrated that thioredoxin (Trx) overexpression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4109c52afb3ea8e5e7a9f4fc3d9653
https://doi.org/10.31491/apt.2020.03.009
https://doi.org/10.31491/apt.2020.03.009
Autor:
Norberto Gonzalez-Juarbe, Angelene M. Cantwell, Harinder Singh, Maryann P. Platt, Yanbao Yu, Peter H. Dube, Gene B. Hubbard, Yan Xiang, Yuji Ikeno, Yi-Han Lin
Publikováno v:
Journal of Virology
The host response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is poorly understood due to a lack of an animal model that recapitulates severe human disease. Here, we report a Syrian hamster model that develops progressive lethal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098073a4d8bd5ed7a5471c1f3f70bec7
http://europepmc.org/articles/PMC8475517
http://europepmc.org/articles/PMC8475517
Autor:
Enrique R. ARGAÑARAZ, Gene B. HUBBARD, Larissa A. RAMOS, Allen L. FORD, Nadjar NITZ, Michelle M. LELAND, John L. VANDEBERG, Antonio R.L. TEIXEIRA
Publikováno v:
Revista do Instituto de Medicina Tropical de São Paulo, Vol 43, Iss 5, Pp 271-276 (2001)
Trypanosoma cruzi (Schyzotrypanum, Chagas, 1909), and Chagas disease are endemic in captive-reared baboons at the Southwest Foundation for Biomedical Research, San Antonio, Texas. We obtained PCR amplification products from DNA extracted from sucking
Externí odkaz:
https://doaj.org/article/cf2b763043f149369b6e7938897c6f54
Autor:
Yidong Bai, Yuji Ikeno, Thomas L. Saunders, Colton Allen, Geneva M. Cunningham, Madeline G. Roman, Christie Cheng, Lisa C. Flores, Gene B. Hubbard
Publikováno v:
Aging Pathobiol Ther
Our laboratory has conducted the first systematic survival studies to examine the biological effects of the antioxidant protein thioredoxin (Trx) on aging and age-related pathology. Our studies with C57BL/6 mice overexpressing Trx1 [Tg(act-TRX1) +/0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669518c20ff07b1e2d4257f30daafa0a
https://europepmc.org/articles/PMC9049237/
https://europepmc.org/articles/PMC9049237/
Autor:
Yuji Ikeno, Jennifer I. Engelmeyer, Björn Schumacher, Jeffrey B. Mason, Gene B. Hubbard, Tracy L. Habermehl, Kate C. Parkinson
Publikováno v:
GeroScience. 41:25-38
Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with you
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a3f9e4ef3c8caf2b2e566e9fd4bead
https://doi.org/10.1007/s11357-018-0049-4
https://doi.org/10.1007/s11357-018-0049-4
Autor:
Alex F Bokov, Neha Garg, Yuji Ikeno, Sachin Thakur, Nicolas Musi, Ralph A DeFronzo, Ning Zhang, Rebecca C Erickson, Jon Gelfond, Gene B Hubbard, Martin L Adamo, Arlan Richardson
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26891 (2011)
Mutations in insulin/IGF-1 signaling pathway have been shown to lead to increased longevity in various invertebrate models. Therefore, the effect of the haplo-insufficiency of the IGF-1 receptor (Igf1r(+/-)) on longevity/aging was evaluated in C57Bl/
Externí odkaz:
https://doaj.org/article/cc091090517441c39e28556c68975de3