Zobrazeno 1 - 10
of 2 470
pro vyhledávání: '"Gene Activation"'
Autor:
Asiya Nazir, Abdul R. Puthuveettil, Fathima Hasnain Nadeem Hussain, Khalid E. Hamed, Nayla Munawar
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
The growing threat of antimicrobial resistance (AMR) has underlined the need for a sustained supply of novel antimicrobial agents. Endophyte microorganism that reside within plant tissues as symbionts have been the source of potential antimicrobial s
Externí odkaz:
https://doaj.org/article/19c2a3f2e9924d89b3af9e1897a8c790
Autor:
Tania Ho-Plágaro, Muhammad Usman, Janne Swinnen, Joske Ruytinx, Françoise Gosti, Isabelle Gaillard, Sabine D. Zimmermann
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Zinc (Zn) shortage is a common micronutrient deficiency affecting plants worldwide, while Zn toxicity may occur when this metal is in excess. Ectomycorrhizal (ECM) fungi are known to be able to modulate the transfer of macro- and microelements, among
Externí odkaz:
https://doaj.org/article/439aae01ae8c49fa8be42e96a51df818
Autor:
Xinyang Bing, Wenfan Ke, Miki Fujioka, Amina Kurbidaeva, Sarah Levitt, Mike Levine, Paul Schedl, James B Jaynes
Publikováno v:
eLife, Vol 13 (2024)
Two different models have been proposed to explain how the endpoints of chromatin looped domains (‘TADs’) in eukaryotic chromosomes are determined. In the first, a cohesin complex extrudes a loop until it encounters a boundary element roadblock,
Externí odkaz:
https://doaj.org/article/69f54650950e47cea510ecc8aa1663b4
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-18 (2024)
Abstract Background Histone acetylation, which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a crucial role in the control of gene expression. HDAC inhibitors (HDACi) have shown potential in cancer therapy;
Externí odkaz:
https://doaj.org/article/3a03bfcb4e1a4d5eaa348b7f100775dc
Publikováno v:
AIMS Microbiology, Vol 9, Iss 4, Pp 780-800 (2023)
There are six major types of CRISPR-Cas systems that provide adaptive immunity in bacteria and archaea against invasive genetic elements. The discovery of CRISPR-Cas systems has revolutionized the field of genetics in many organisms. In the past few
Externí odkaz:
https://doaj.org/article/f127dfa130e24107b107839a9c7ceea8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Genes involved in gonadal sex differentiation have been traditionally thought to be fairly conserved across vertebrates, but this has been lately questioned. Here, we performed the first comparative analysis of gonadal transcriptomes across vertebrat
Externí odkaz:
https://doaj.org/article/1e3d6a6bd8054174a3d9d4297f78f401
Autor:
Xin Zhang, Xinlong Wang, Jie Lv, Hongxin Huang, Jiahong Wang, Ma Zhuo, Zhihong Tan, Guanjie Huang, Jiawei Liu, Yuchen Liu, Mengrao Li, Qixiao Lin, Lian Li, Shufeng Ma, Tao Huang, Ying Lin, Xiaoyang Zhao, Zhili Rong
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background The CRISPR/Cas12a and CRISPR/Cas13d systems are widely used for fundamental research and hold great potential for future clinical applications. However, the short half-life of guide RNAs (gRNAs), particularly free gRNAs without Ca
Externí odkaz:
https://doaj.org/article/a0460a87573647bd89dabb707e89abe6
Autor:
Moira A. McMahon, Meghdad Rahdar, Swagatam Mukhopadhyay, Huynh-Hoa Bui, Christopher Hart, Sagar Damle, Margo Courtney, Michael W. Baughn, Don W. Cleveland, C. Frank Bennett
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 289-301 (2023)
Antisense oligonucleotides (ASOs) are short synthetic nucleic acids that recognize and bind to complementary RNA to modulate gene expression. It is well established that single-stranded, phosphorothioate-modified ASOs enter cells independent of carri
Externí odkaz:
https://doaj.org/article/b4603aa807a3456aa6ae0c476b922870
Autor:
Marta Suarez-Fernandez, Rocio Álvarez-Aragón, Ana Pastor-Mediavilla, Alejandro Maestre-Guillén, Ivan del Olmo, Agustina De Francesco, Lukas Meile, Andrea Sánchez-Vallet
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Effector proteins are secreted by plant pathogens to enable host colonization. Typically, effector genes are tightly regulated, have very low expression levels in axenic conditions, and are strongly induced during host colonization. Chromati
Externí odkaz:
https://doaj.org/article/09f496147676490f8922899b4cb369bb
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 202-211 (2023)
CRISPR-mediated epigenome editing enables gene expression regulation without changing the underlying DNA sequence, and thus has vast potential for basic research and gene therapy. Effective selection of a single guide RNA (sgRNA) with high on-target
Externí odkaz:
https://doaj.org/article/1a32b1f614654ee38364a4f822e6528c