Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Gene M. Dubowchik"'
Autor:
Richard A. Hartz, Vijay T. Ahuja, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R. Burton, John E. Macor, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry. 66:4231-4252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c0e6aab6246e0fca5a7a308d8d66217
https://doi.org/10.1021/acs.jmedchem.3c00133
https://doi.org/10.1021/acs.jmedchem.3c00133
Autor:
Richard A. Hartz, Vijay T. Ahuja, Guanglin Luo, Ling Chen, Prasanna Sivaprakasam, Hong Xiao, Carol M. Krause, Wendy J. Clarke, Songmei Xu, John S. Tokarski, Kevin Kish, Hal Lewis, Nicolas Szapiel, Ramu Ravirala, Sayali Mutalik, Deepa Nakmode, Devang Shah, Catherine R. Burton, John E. Macor, Gene M. Dubowchik
Publikováno v:
Journal of Medicinal Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973dc3947e6104a7b54e9172d7ba1d5f
https://doi.org/10.1021/acs.jmedchem.3c00364
https://doi.org/10.1021/acs.jmedchem.3c00364
Autor:
Guanglin Luo, Ling Chen, Swanee Jacutin-Porte, Catherine R. Burton, Hong Xiao, Prasanna Sivaprakasam, Carol M. Krause, Yang Cao, Nengyin Liu, Michelle Nophsker, Kimberly Snow, Wendy J. Clarke, Kevin Kish, Hal Lewis, John E. Macor, Gene M. Dubowchik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad30add637bc21523a74e6c3a8104703
https://doi.org/10.2139/ssrn.4411756
https://doi.org/10.2139/ssrn.4411756
Publikováno v:
Journal of Medicinal Chemistry. 63:6600-6623
The pivotal role of calcitonin gene-related peptide (CGRP) in migraine pathophysiology was identified over 30 years ago, but the successful clinical development of targeted therapies has only recently been realized. This Perspective traces the decade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a528002888785606e57c78163653fd4f
https://doi.org/10.1021/acs.jmedchem.9b01810
https://doi.org/10.1021/acs.jmedchem.9b01810
Autor:
Guanglin Luo, Ling Chen, Swanee Jacutin-Porte, Ying Han, Catherine R. Burton, Hong Xiao, Carol M. Krause, Yang Cao, Nengyin Liu, Kevin Kish, Hal A. Lewis, John E. Macor, Gene M. Dubowchik
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 81:129143
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f64342d6a338ff20e4794119b7252a8
https://doi.org/10.1016/j.bmcl.2023.129143
https://doi.org/10.1016/j.bmcl.2023.129143
Autor:
Sokhom S. Pin, Deborah A. Cook, John E. Macor, Laura J. Signor, Carl Davis, Valerie J. Whiterock, Gene M. Dubowchik, Richard Schartman, Ping Chen, Chaturvedula Prasad, Kimberly A. Widmann, George Thalody, Walter Kostich, Robert Macci, John J. Herbst, Stephen E. Mercer, Charles M. Conway, Cen Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 31
Calcitonin gene-related peptide (CGRP) receptor antagonists have been shown clinically to be effective treatments for migraine. Zavegepant (BHV-3500, BMS-742413) is a high affinity antagonist of the CGRP receptor (hCGRP Ki = 0.023 nM) that has demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1b018775ed0613c97b43faeac8e918
https://pubmed.ncbi.nlm.nih.gov/33096162
https://pubmed.ncbi.nlm.nih.gov/33096162
Autor:
Gene M. Dubowchik, Benjamin M. Johnson, John E. Macor, Charles M. Conway, Guanglin Luo, Walter Kostich, Ling Chen, Alicia Ng
Publikováno v:
The Journal of Organic Chemistry. 82:3710-3720
An asymmetric synthesis of the major metabolite of the calcitonin gene-related peptide recepotor antagonist BMS-846372 is presented. The variously substituted cyclohepta[b]pyridine ring system represents an underexplored ring system and showed some u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3498d965338d54a0b491ab7a51b05b
https://doi.org/10.1021/acs.joc.7b00052
https://doi.org/10.1021/acs.joc.7b00052
Autor:
Robert Croop, David A. Stock, Vladimir Coric, Peter J. Goadsby, Richard B. Lipton, Charles M. Conway, Beth Morris, Gene M. Dubowchik, Elyse Stock, Marianne Frost
Publikováno v:
The New England journal of medicine. 381(2)
Calcitonin gene-related peptide receptor has been implicated in the pathogenesis of migraine. Rimegepant is an orally administered, small-molecule, calcitonin gene-related peptide receptor antagonist that may be effective in acute migraine treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbbf0092e1e0a0296f0142bf9c081c5
https://pubmed.ncbi.nlm.nih.gov/31739342
https://pubmed.ncbi.nlm.nih.gov/31739342
Autor:
Matt Pokross, Jonathan Lippy, Guanglin Luo, Vinod Arora, Hong Xiao, Nengyin Liu, John E. Macor, Joseph Raybon, Wendy Clarke, Catherine R. Burton, David R. Langley, Carol M. Krause, Gene M. Dubowchik, Yang Cao, Ling Chen, Hal A. Lewis, Kimberly Snow, Prasanna Sivaprakasam, Kevin Kish
Publikováno v:
Journal of Medicinal Chemistry. 59:1041-1051
GSK-3 is a serine/threonine kinase that has numerous substrates. Many of these proteins are involved in the regulation of diverse cellular functions, including metabolism, differentiation, proliferation, and apoptosis. Inhibition of GSK-3 may be usef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6b7565032e7ab38f139d202ec3bbb6
https://doi.org/10.1021/acs.jmedchem.5b01550
https://doi.org/10.1021/acs.jmedchem.5b01550
Publikováno v:
Organic Letters. 17:5982-5985
An asymmetric synthesis of novel heterocyclic analogue of the CGRP receptor antagonist rimegepant (BMS-927711, 3) is reported. The cycloheptane ring was constructed by an intramolecular Heck reaction. The application of Hayashi-Miyaura and Ellman rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bbb0317099219e75aa70db70999b6a
https://doi.org/10.1021/acs.orglett.5b02921
https://doi.org/10.1021/acs.orglett.5b02921