The molecular basis of breast cancer pathological phenotypes.

Autor: Heng YJ; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA., Lester SC; Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA., Tse GM; Department of Anatomical & Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong., Factor RE; Department of Pathology, School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Allison KH; Department of Pathology, School of Medicine, Stanford Medical Center, Stanford University, Stanford, CA, USA., Collins LC; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA., Chen YY; Department of Pathology, School of Medicine, University of California, San Francisco, CA, USA., Jensen KC; Department of Pathology, School of Medicine, Stanford Medical Center, Stanford University, Stanford, CA, USA.; VA Palo Alto Healthcare System, Palo Alto, CA, USA., Johnson NB; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA., Jeong JC; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA., Punjabi R; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA., Shin SJ; Department of Pathology & Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA., Singh K; Department of Pathology & Laboratory Medicine, Brown University, Providence, RI, USA., Krings G; Department of Pathology, School of Medicine, University of California, San Francisco, CA, USA., Eberhard DA; Department of Pathology & Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Tan PH; Department of Pathology, Singapore General Hospital, Singapore., Korski K; Department of Pathology, Greater Poland Cancer Centre, Poznan, Poland., Waldman FM; Department of Laboratory Medicine, School of Medicine, University of California, San Francisco, CA, USA., Gutman DA; Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA, USA., Sanders M; Department of Pathology, Microbiology and Immunology, Vanderbilt University, Nashville, TN, USA., Reis-Filho JS; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Flanagan SR; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA., Gendoo DM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, ON, Canada., Chen GM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Haibe-Kains B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, ON, Canada., Ciriello G; Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland., Hoadley KA; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Perou CM; Department of Pathology & Laboratory Medicine, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.; Department of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC, USA., Beck AH; Cancer Research Institute, Beth Israel Deaconess Cancer Center, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Publikováno v: The Journal of pathology [J Pathol] 2017 Feb; Vol. 241 (3), pp. 375-391. Date of Electronic Publication: 2016 Dec 29.

PharmacoGx: an R package for analysis of large pharmacogenomic datasets.

Autor: Smirnov P; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Safikhani Z; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., El-Hachem N; Institut De Recherches Cliniques De Montréal, Montreal, QC, Canada., Wang D; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., She A; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Olsen C; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Interuniversity Institute of Bioinformatics in Brussels (IB)2, Brussels, Belgium, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Freeman M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Selby H; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA, Department of Bioinformatics, Boston University, Boston, MA, USA., Gendoo DM; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Grossmann P; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Beck AH; Beth Israel Deaconess Medical Center, Boston, MA, USA., Aerts HJ; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Lupien M; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Machine Learning Group (MLG), Department d'Informatique, Université libre de Bruxelles (ULB), Brussels, Belgium, Ontario Institute of Cancer Research, Toronto, ON, Canada., Goldenberg A; Hospital for Sick Children, Toronto, ON, Canada and Department of Computer Science, University of Toronto, Toronto, ON, Canada., Haibe-Kains B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2016 Apr 15; Vol. 32 (8), pp. 1244-6. Date of Electronic Publication: 2015 Dec 09.

Genefu: an R/Bioconductor package for computation of gene expression-based signatures in breast cancer.

Autor: Gendoo DM; Bioinformatics and Computational Laboratory, Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Ratanasirigulchai N; Bioinformatics and Computational Laboratory, Princess Margaret Cancer Centre, University Health Network and., Schröder MS; UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, UK., Paré L; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain., Parker JS; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA., Prat A; Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), 08036 Barcelona, Spain, Translational Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain and Department of Medical Oncology, Hospital Clínic of Barcelona, 08036 Barcelona, Spain., Haibe-Kains B; Bioinformatics and Computational Laboratory, Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.

Publikováno v: Bioinformatics (Oxford, England) [Bioinformatics] 2016 Apr 01; Vol. 32 (7), pp. 1097-9. Date of Electronic Publication: 2015 Nov 24.

Personalized diagnosis of medulloblastoma subtypes across patients and model systems.

Autor: Gendoo DM; Bioinformatics and Computational Genomics Laboratory, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada; Medical Biophysics Department, University of Toronto, Toronto, Ontario, Canada. Electronic address: deena.gendoo@utoronto.ca., Smirnov P; Bioinformatics and Computational Genomics Laboratory, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada., Lupien M; Bioinformatics and Computational Genomics Laboratory, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada; Medical Biophysics Department, University of Toronto, Toronto, Ontario, Canada; Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada., Haibe-Kains B; Bioinformatics and Computational Genomics Laboratory, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada; Medical Biophysics Department, University of Toronto, Toronto, Ontario, Canada. Electronic address: bhaibeka@uhnresearch.ca.

Publikováno v: Genomics [Genomics] 2015 Aug; Vol. 106 (2), pp. 96-106. Date of Electronic Publication: 2015 May 12.

Medulloblastoma subgroups remain stable across primary and metastatic compartments.

Autor: Wang X; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Dubuc AM, Ramaswamy V, Mack S, Gendoo DM, Remke M, Wu X, Garzia L, Luu B, Cavalli F, Peacock J, López B, Skowron P, Zagzag D, Lyden D, Hoffman C, Cho YJ, Eberhart C, MacDonald T, Li XN, Van Meter T, Northcott PA, Haibe-Kains B, Hawkins C, Rutka JT, Bouffet E, Pfister SM, Korshunov A, Taylor MD

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2015 Mar; Vol. 129 (3), pp. 449-57. Date of Electronic Publication: 2015 Jan 21.