Successful management of a multi-species outbreak of carbapenem-resistant organisms in Fiji: a prospective genomics-enhanced investigation and response.

Autor: Young-Sharma T; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Lane CR; WHO Collaborating Centre for Antimicrobial Resistance, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Centre for Pathogen Genomics, Doherty Institute, University of Melbourne, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., James R; WHO Collaborating Centre for Antimicrobial Resistance, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Microbiology Unit and Department of Infectious Diseases, Alfred Hospital, Melbourne, Australia., Wilmot M; WHO Collaborating Centre for Antimicrobial Resistance, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Autar S; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Hui K; WHO Collaborating Centre for Antimicrobial Resistance, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Strobel AG; Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Lacey JA; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Kumar S; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Datt A; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Lata A; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Cameron D; WHO Collaborating Centre for Antimicrobial Resistance, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia., Sherry NL; WHO Collaborating Centre for Antimicrobial Resistance, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Department of Microbiology and Immunology, Austin Health, Heidelberg, Australia., Genaro S; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Ditukana T; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Nabose I; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Goneyali A; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Bennett E; Fiji National University, Suva, Fiji., Kavoa A; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Prasad S; Australian Volunteers International, Suva, Fiji., Vakamocea A; Fiji Program Support Facility, Suva, Fiji., Suka A; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Prasad P; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Hussein F; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Lin C; WHO Collaborating Centre for Antimicrobial Resistance, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Centre for Pathogen Genomics, Doherty Institute, University of Melbourne, Melbourne, Australia., Jenney AW; Fiji National University, Suva, Fiji.; Microbiology Unit and Department of Infectious Diseases, Alfred Hospital, Melbourne, Australia.; School of Translational Medicine, Monash University, Melbourne, Australia., Buising K; Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; The Royal Melbourne Hospital, Melbourne, Australia., Naidu R; Ministry of Health and Medical Services, Colonial War Memorial Hospital, Suva, Fiji., Howden BP; WHO Collaborating Centre for Antimicrobial Resistance, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Centre for Pathogen Genomics, Doherty Institute, University of Melbourne, Melbourne, Australia.; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.; Department of Microbiology and Immunology, Austin Health, Heidelberg, Australia.

Publikováno v: The Lancet regional health. Western Pacific [Lancet Reg Health West Pac] 2024 Nov 20; Vol. 53, pp. 101234. Date of Electronic Publication: 2024 Nov 20 (Print Publication: 2024).

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Autor: Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and anti

Externí odkaz: https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887

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Scaffold-Based Analytics: Enabling Hit-to-Lead Decisions by Visualizing Chemical Series Linked across Large Datasets

Autor: Tyler Peryea, Genaro S. Scavello, Zangdong He, Joseph Boyer, Pat Brady, Deepak Bandyopadhyay, Rajarshi Guha, Ajit Jadhav, Constantine Kreatsoulas, Dac-Trung Nguyen

Publikováno v: Journal of Chemical Information and Modeling. 59:4880-4892

We present a method for visualizing and navigating large screening datasets while also taking into account their activities and properties. Our approach is to annotate the data with all possible scaffolds contained within each molecule. We have devel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0d8623e816e894d928eee6656ad97bd
https://doi.org/10.1021/acs.jcim.9b00243

Correction: Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Autor: Jeffrey A. Messer, Yun Ding, Jianghe Deng, Paolo A. Centrella, Todd L. Graybill, Jean Zhang, Patti McCormick, Carl A. Machutta, Robert H. Bates, John Martin, Joël Lelièvre, Quinn Lu, Jingye Zhou, Alfonso Mendoza-Losana, Xiaopeng Bai, Christopher S. Kollmann, David J. Holmes, Keith Rafferty, Christina S. Pao, Christopher C. Arico-Muendel, Heather O’Keefe, Aaron Coffin, Taylor L. Graham, David Barros-Aguirre, Sandy Chang, Christopher P. Davie, Hongwei Qi, Flora S. Sundersingh, Minghui Wang, Karen A. Ingraham, Jing Chai, Thomas O’Keeffe, Juan Wang, Gang Yao, Lluis Ballell, Jianzhong Huang, Anthony E. Choudhry, Bryan W. King, Andrew J. Pope, Ghotas Evindar, Xiaorong Liu, May Fern Toh, Christine Patricia Donahue, Jeffrey W. Gross, Pan F. Chan, Walter P. Johnson, Ruth Lehr, Hongfeng Deng, Kenneth E Lind, Matt S. Steiginga, Jason W. Dodson, Gurdyal S. Besra, Amy N. Taylor, Devan J. Wilkins, Yue Li, Lawrence M. Szewczuk, Svetlana L. Belyanskaya, Genaro S. Scavello, Sharon Sweitzer, Christopher R. Kwiatkowski, Lynn McCloskey, Bing Xia, Enoch Gao, Christopher B. Phelps, David T. Fosbenner

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87eaf46a6638b2650fa3a4f95e4cf2b
https://doi.org/10.1038/ncomms16227