Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gena Whitney"'
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 902-913 (2012)
2′,5′-linked oligoadenylates (2-5As) serve as conserved messengers of pathogen presence in the mammalian innate immune system. 2-5As induce self-association and activation of RNase L, which cleaves cytosolic RNA and promotes the production of int
Externí odkaz:
https://doaj.org/article/61d4314c8aa645cda2f77d21e8636b02
Autor:
Tiffany M. Richardson, Denis L. J. Lafontaine, Clifford P. Brangwynne, Ming-Tzo Wei, Ludivine Wacheul, Gena Whitney, Marina Feric, Lian Zhu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 116 (35
The nucleolus is a prominent nuclear condensate that plays a central role in ribosome biogenesis by facilitating the transcription and processing of nascent ribosomal RNA (rRNA). A number of studies have highlighted the active viscoelastic nature of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2825a0264e63e1e118c8e4e8825f912f
https://doi.org/10.1073/pnas.1903870116
https://doi.org/10.1073/pnas.1903870116
Autor:
Paul A. Anderson, Pavel Ivanov, William M. Jacobs, Clifford P. Brangwynne, Ming-Tzo Wei, Dan Bracha, Shawn M. Lyons, Amy R. Strom, Victoria Drake, David W. Sanders, Allana Iwanicki, Jorine M. Eeftens, Daniel S.W. Lee, Joshua A. Riback, Nancy Kedersha, Gena Whitney, Alicia Wang
Publikováno v:
Cell
Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate their assembly, substructure, and coexistence with other liquid-like compartments remain elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97141a20d09837f3bd1ccc54e93950db
https://pubmed.ncbi.nlm.nih.gov/32302565
https://pubmed.ncbi.nlm.nih.gov/32302565
Publikováno v:
Proceedings of the National Academy of Sciences. 112:3949-3954
The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2',5'-linked RNA molecules (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c49ec892352a8d4db1098ac0d8d3108
https://doi.org/10.1073/pnas.1419409112
https://doi.org/10.1073/pnas.1419409112
Publikováno v:
Science. 343:1244-1248
Crossed Homodimer Our cells respond to infection by releasing interferons, which protect neighboring cells, in part through the cleavage of intracellular RNA by a protein kinase family receptor, RNase L. RNase L is activated by 2′,5″-linked oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e51df54b4d3ffe302afdd6c2cfd33c
https://doi.org/10.1126/science.1249845
https://doi.org/10.1126/science.1249845
Publikováno v:
Proceedings of the National Academy of Sciences
Double-stranded RNA (dsRNA) activates the innate immune system of mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease RNase L. RNase L protects from pathogens and regulates cell growth and differentiation by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7515c2118a7b4502954e47026c78c3
https://pubmed.ncbi.nlm.nih.gov/26668391
https://pubmed.ncbi.nlm.nih.gov/26668391