Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Gena Lapointe"'
Autor:
Molly He, Timothy D. Machajewski, Daniel Menezes, Frazier Kelly, William R. Antonios-Mccrea, Jayesh Vora, Vincent P. Le, Warne Robert L, Gena Lapointe, Cynthia M. Shafer, Jazan Elisa, Sabina Pecchi, Paul Feucht, Helen Ye, Clarke Albany Taylor, Johanna M. Jansen, Mary Ellen Wernette-Hammond, Marion Wiesmann, Alex L. Harris, Carla Heise, Christopher McBride, Paul A. Renhowe, Kimberly Aardalen
Publikováno v:
Journal of Medicinal Chemistry. 52:278-292
The inhibition of key receptor tyrosine kinases (RTKs) that are implicated in tumor vasculature formation and maintenance, as well as tumor progression and metastasis, has been a major focus in oncology research over the last several years. Many pote
Publikováno v:
Journal of Neurochemistry. 66:1707-1716
Four neurotrophic factors, important for survival and function of neurons, bind a common receptor, the 75-kDa neurotrophin receptor (NTR). An O-glycosylated peptide connects the ligand-binding domain of NTR to its transmembrane helix. This peptide, t
Autor:
Sylvia Ma, Ramon Piñeda, Cynthia M. Shafer, Jayesh Vora, Carla Heise, Gena Lapointe, Johanna M. Jansen, Paul A. Renhowe, Marion Wiesmann, Christopher McBride
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(13)
3-Benzimidazol-2-yl-1H-indazole analogs were developed as inhibitors of receptor tyrosine kinases (RTK). The synthesis and SAR of this series is reported.
Autor:
Cynthia M. Shafer, Jayesh Vora, Gena Lapointe, Sabina Pecchi, Kelly A. Frazier, Paul A. Renhowe, Marion Wiesmann, Clarke Taylor, Christopher McBride, Jazan Elisa, Dirksen E. Bussiere, Molly Min He, Sylvia Ma, Johanna M. Jansen
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(8)
Herein are described a series of novel heterocyclic analogs of the 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one scaffold. These compounds are potent inhibitors of receptor tyrosine kinases and exhibit favorable pharmacokinetic profiles. The synthes