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pro vyhledávání: '"GenOMICC Investigators"'
Akademický článek
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Akademický článek
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Autor:
Clark D Russell, Erola Pairo-Castineira, Malcolm G Semple, James F. Wilson, Jian Yang, andMe Investigators, Seán Keating, Yang Wu, Tala Zainy, Greg Elgar, Angie Fawkes, Lucija Klaric, Julian C. Knight, Paul Elliott, Richard H Scott, Charlotte Summers, David M. Maslove, Daniel F. McAuley, Marie Zechner, Sally Donovan, J Kenneth Baillie, Athanasios Kousathanas, Daniel Rhodes, Nicholas J. Parkinson, Veronique Vitart, Susan P. Walker, Peter Horby, Fiona Griffiths, Bo Wang, Peter J. M. Openshaw, Linda Todd, Andy Law, Sara Clohisey, Tom Fowler, Augusto Rendon, Alex Stuckey, Christopher A Odhams, Andrew D. Bretherick, Hugh Montgomery, Katherine S. Elliott, Shahla Salehi, Jonathan E Millar, Loukas Moutsianas, Charles J. Hinds, Kathy Rowan, Mark J. Caulfield, Fiona Maleady-Crowe, Timothy S. Walsh, Prabhu Arumugam, Georgia Chan, Lee Murphy, Afshan Siddiq, GenoMICC Investigators, Tomas Malinauskas, Konrad Rawlik, Kirstie Morrice, Chris P. Ponting, Alistair Nichol, Wilna Oosthuyzen, Manu Shankar-Hari, Peter Goddard
Critical illness in COVID-19 is caused by inflammatory lung injury, mediated by the host immune system. We and others have shown that host genetic variation influences the development of illness requiring critical care1or hospitalisation2;3;4followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9527a5c19bf64badc19950b71a8524
https://doi.org/10.1101/2021.09.02.21262965
https://doi.org/10.1101/2021.09.02.21262965
Autor:
Pairo-Castineira, Erola, Clohisey, Sara, Klaric, Lucija, Bretherick, Andrew D., Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Parkinson, Nick, Head Fourman, Max, Russell, Clark D., Furniss, James, Richmond, Anne, Gountouna, Elvina, Wrobel, Nicola, Harrison, David, Wang, Bo, Wu, Yang, Meynert, Alison, Griffiths, Fiona, Oosthuyzen, Wilna, Kousathanas, Athanasios, Moutsianas, Loukas, Yang, Zhijian, Zhai, Ranran, Zheng, Chenqing, Grimes, Graeme, Beale, Rupert, Millar, Jonathan, Shih, Barbara, Keating, Sean, Zechner, Marie, Haley, Chris, Porteous, David J., Hayward, Caroline, Yang, Jian, Knight, Julian, Summers, Charlotte, Shankar-Hari, Manu, Klenerman, Paul, Turtle, Lance, Ho, Antonia, Moore, Shona C., Hinds, Charles, Horby, Peter, Maslove, David, Ling, Lowell, McAuley, Danny, Montgomery, Hugh, Walsh, Timothy, Pereira, Alex, Renieri, Alessandra, The GenOMICC Investigators, ., The ISARIC-4C Investigators, ., The Covid-19 Human Genetics Initiative, ., 23andMe Investigators, ., BRACOVID Investigators, ., Gen-COVID Investigators, ., Shen, Xia, Ponting, Chris P., Fawkes, Angie, Tenesa, Albert, Caulfield, Mark, Scott, Richard, Rowan, Kathy, Openshaw, Peter J.M., Semple, Malcolm G., Law, Andrew, Vitart, Veronique, Wilson, James F., Baillie, J. Kenneth
Host-mediated lung inflammation is present,1 and drives mortality,2 in critical illness caused by Covid-19. Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development.3 Here we report the resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4a22278d62c0e851fbf28b1cef08e087
https://eprints.gla.ac.uk/226569/3/226569.pdf
https://eprints.gla.ac.uk/226569/3/226569.pdf
Autor:
Alessia David, Nicholas Parkinson, Thomas P. Peacock, Erola Pairo-Castineira, Tarun Khanna, Aurelie Cobat, Albert Tenesa, Vanessa Sancho-Shimizu, GenOMICC Investigators Group, Jean-Laurent Casanova, Laurent Abel, Wendy S. Barclay, J. Kenneth Baillie, Michael Sternberg
Publikováno v:
SSRN Electronic Journal.
Background: The human protein transmembrane protease serine type 2 (TMPRSS2) plays a key role in SARS-CoV-2 infection, as it is required to activate the virus’ spike protein, facilitating entry into target cells. We hypothesized that naturally-occu