Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gen-mu Zhang"'
Autor:
Viraj Kulkarni, Margherita Rosati, Antonio Valentin, Brunda Ganneru, Ashish K Singh, Jian Yan, Morgane Rolland, Candido Alicea, Rachel Kelly Beach, Gen-Mu Zhang, Sylvie Le Gall, Kate E Broderick, Niranjan Y Sardesai, David Heckerman, Beatriz Mothe, Christian Brander, David B Weiner, James I Mullins, George N Pavlakis, Barbara K Felber
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60245 (2013)
Viral diversity is considered a major impediment to the development of an effective HIV-1 vaccine. Despite this diversity, certain protein segments are nearly invariant across the known HIV-1 Group M sequences. We developed immunogens based on the hi
Externí odkaz:
https://doaj.org/article/6e5bcd65126b4ecd85d70afccbff0b95
Autor:
Gen-Mu Zhang, Rashmi Jalah, Niranjan Y. Sardesai, Viraj Kulkarni, Candido Alicea, Margherita Rosati, Cristina Bergamaschi, Brunda Ganneru, George N. Pavlakis, Guy R. Pilkington, Antonio Valentin, Barbara K. Felber, Kate E. Broderick, Bhabadeb Chowdhury, Rachel Kelly Beach
Publikováno v:
Journal of Biological Chemistry. 288:6763-6776
IL-12 is a 70-kDa heterodimeric cytokine composed of the p35 and p40 subunits. To maximize cytokine production from plasmid DNA, molecular steps controlling IL-12p70 biosynthesis at the posttranscriptional and posttranslational levels were investigat
Autor:
Agneta von Gegerfelt, Candido Alicea, Barbara K. Felber, Kate E. Broderick, George N. Pavlakis, Cristina Bergamaschi, Bhabadeb Chowdhury, Gen-Mu Zhang, Antonio Valentin, Margherita Rosati, Viraj Kulkarni, Niranjan Y. Sardesai, Rashmi Jalah, Vainav Patel, Brunda Ganneru
Publikováno v:
Vaccine. 29:6742-6754
Optimized DNA vectors were constructed comprising the proteome of SIV including the structural, enzymatic, regulatory, and accessory proteins. In addition to native antigens as produced by the virus, fusion proteins and modified antigens with altered
Autor:
Barbara K. Felber, Viraj Kulkarni, Cristina Bergamaschi, George N. Pavlakis, Gen-Mu Zhang, Andrei S. Zolotukhin, Candido Alicea, Rashmi Jalah, Margherita Rosati
Publikováno v:
J Immunol
The two known isoforms of IL-15 contain either a long signal peptide (LSP) or a short signal peptide (SSP), and are produced by alternatively spliced transcripts. It has been proposed that SSP IL-15 remains exclusively intracellular, and its function
Autor:
Barbara K. Felber, Susan Lindtner, Gen Mu Zhang, Jenifer Bear, Andrei S. Zolotukhin, Hiroaki Uranishi, Søren Warming, George N. Pavlakis, Neal G. Copeland, Nancy A. Jenkins
Publikováno v:
The Journal of Biological Chemistry
The human SPEN family proteins SHARP, RBM15/OTT1, and RBM15B/OTT3 share the structural domain architecture but show distinct functional properties. Here, we examined the function of OTT3 and compared it with its paralogues RBM15 and SHARP. We found t
Publikováno v:
Cancer Cell. 9:445-457
In the liver, derangement of TGF-beta signaling is associated with an increased incidence of hepatocellular carcinoma (HCC), but the mechanism is not clear. We report here that forced expression of a major TGF-beta signaling transducer, Smad3, reduce
Autor:
Sai-Xia Ying, Gen-mu Zhang, Chu-Xia Deng, Motozo Yamashita, Ying E. Zhang, Steven Y. Cheng, Cuiling Li
Publikováno v:
Cell. 121(1):101-113
SummaryBone is constantly resorbed and formed throughout life by coordinated actions of osteoclasts and osteoblasts. Here we show that Smurf1, a HECT domain ubiquitin ligase, has a specific physiological role in suppressing the osteogenic activity of
Autor:
Antonio Valentin, Cristina Bergamaschi, Guy R. Pilkington, Wensheng Huang, Ashish Singh, Niranjan Y. Sardesai, Margherita Rosati, Barbara K. Felber, Gen-Mu Zhang, Eun Young Kim, David C. Montefiori, Kate E. Broderick, Jenifer Bear, Steven M. Wolinsky, Candido Alicea, Celia C. LaBranche, Rashmi Jalah, Bhabadeb Chowdhury, Yongjun Guan, Viraj Kulkarni, George N. Pavlakis
A panel of SIVmac251 transmitted Env sequences were tested for expression, function and immunogenicity in mice and macaques. The immunogenicity of a DNA vaccine cocktail expressing SIVmac239 and three transmitted SIVmac251 Env sequences was evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbddaeead162017f82d43658ea66867
https://europepmc.org/articles/PMC3906392/
https://europepmc.org/articles/PMC3906392/
Autor:
Rashmi, Jalah, Margherita, Rosati, Brunda, Ganneru, Guy R, Pilkington, Antonio, Valentin, Viraj, Kulkarni, Cristina, Bergamaschi, Bhabadeb, Chowdhury, Gen-Mu, Zhang, Rachel Kelly, Beach, Candido, Alicea, Kate E, Broderick, Niranjan Y, Sardesai, George N, Pavlakis, Barbara K, Felber
Publikováno v:
The Journal of Biological Chemistry
Background: The biosynthesis of IL-12p70 depends on the intracellular interaction of its p35 and p40 subunits. Results: The p40 subunit stabilizes p35 and promotes its secretion. Conclusion: Understanding the regulatory steps of IL-12 biosynthesis le
Autor:
Viraj Kulkarni, Barbara K. Felber, George N. Pavlakis, Candido Alicea, Gen-Mu Zhang, Vainav Patel, Rashmi Jalah, Cristina Bergamaschi, Margherita Rosati, Antonio Valentin
Publikováno v:
The Journal of biological chemistry. 283(7)
We show that co-expression of interleukin 15 (IL-15) and IL-15 receptor alpha (IL-15Ralpha) in the same cell allows for the intracellular interaction of the two proteins early after translation, resulting in increased stability and secretion of both