Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Gen Matsumae"'
Autor:
Hend Alhasan, Mohamad Alaa Terkawi, Gen Matsumae, Taku Ebata, Yuan Tian, Tomohiro Shimizu, Yoshio Nishida, Shunichi Yokota, Fayna Garcia-Martin, Mahmoud M. Abd Elwakil, Daisuke Takahashi, Mahmoud A. Younis, Hideyoshi Harashima, Ken Kadoya, Norimasa Iwasaki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Periprosthetic osteolysis is a cause of arthroplasty failure without available therapies. Here the authors show that Annexin A1 (AnxA1) is involved in in periprosthetic osteolysis and exerts potential therapeutic effects through suppressing NFκB sig
Externí odkaz:
https://doaj.org/article/73c0d2c1acb2480f8d5190e57ab5d6df
Autor:
Gen Matsumae, Tomohiro Shimizu, Yuan Tian, Daisuke Takahashi, Taku Ebata, Hend Alhasan, Shunichi Yokota, Ken Kadoya, Mohamad Alaa Terkawi, Norimasa Iwasaki
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 3, Pp n/a-n/a (2021)
Abstract Macrophages are generally thought to play a key role in the pathogenesis of aseptic loosening through initiating periprosthetic inflammation and pathological bone resorption. The aim of this study was to identify macrophage‐derived factors
Externí odkaz:
https://doaj.org/article/5f8c822d6b2f4e8b85479659bb8ed5d5
Autor:
Taku Ebata, Mohamad Alaa Terkawi, Masanari Hamasaki, Gen Matsumae, Tomohiro Onodera, Mahmoud Khamis Aly, Shunichi Yokota, Hend Alhasan, Tomohiro Shimizu, Daisuke Takahashi, Kentaro Homan, Ken Kadoya, Norimasa Iwasaki
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102643- (2021)
Summary: Synovial macrophages that are activated by cartilage fragments initiate synovitis, a condition that promotes hypertrophic changes in chondrocytes leading to cartilage degeneration in OA. In this study, we analyzed the molecular response of c
Externí odkaz:
https://doaj.org/article/e74a4b47c9f4466e90de54e64bac8b2f
Autor:
M Alaa Terkawi, Taku Ebata, Shunichi Yokota, Daisuke Takahashi, Tsutomu Endo, Gen Matsumae, Tomohiro Shimizu, Ken Kadoya, Norimasa Iwasaki
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1109 (2022)
Osteoarthritis (OA) is a musculoskeletal disease characterized by cartilage degeneration and stiffness, with chronic pain in the affected joint. It has been proposed that OA progression is associated with the development of low-grade inflammation (LG
Externí odkaz:
https://doaj.org/article/e14aca6db0b242c1958e3fced779f0d2
Autor:
M Alaa Terkawi, Gen Matsumae, Tomohiro Shimizu, Daisuke Takahashi, Ken Kadoya, Norimasa Iwasaki
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1786 (2022)
Bone is a mineralized and elastic connective tissue that provides fundamental functions in the human body, including mechanical support to the muscles and joints, protection of vital organs and storage of minerals. Bone is a metabolically active orga
Externí odkaz:
https://doaj.org/article/374699858b874b0da1b516aedd34b38d
Autor:
Yuan Tian, Mohamad Alaa Terkawi, Tomohiro Onodera, Hend Alhasan, Gen Matsumae, Daisuke Takahashi, Masanari Hamasaki, Taku Ebata, Mahmoud Khamis Aly, Hiroaki Kida, Tomohiro Shimizu, Keita Uetsuki, Ken Kadoya, Norimasa Iwasaki
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Periprosthetic osteolysis induced by orthopedic implant-wear particles continues to be the leading cause of arthroplasty failure in majority of patients. Release of the wear debris results in a chronic local inflammatory response typified by the recr
Externí odkaz:
https://doaj.org/article/667b1b0170034e52a40a5be80274d9fb
Autor:
Shunichi, Yokota, Tomohiro, Shimizu, Gen, Matsumae, Taku, Ebata, Hend, Alhasan, Daisuke, Takahashi, Mohamad Alaa, Terkawi, Norimasa, Iwasaki
Publikováno v:
The American Journal of Pathology. 192(5):794-804
Rapidly destructive coxopathy (RDC), a rare disease of unknown etiology, is characterized by the rapid destruction of the hip joint. In the current study, the potential involvement of inflammasome signaling in the progression of RDC was investigated.
Autor:
Taku Ebata, Mohamad Alaa Terkawi, Keita Kitahara, Syunichi Yokota, Junki Shiota, Yoshio Nishida, Gen Matsumae, Hend Alhasan, Masanari Hamasaki, Kazutoshi Hontani, Tomohiro Shimizu, Daisuke Takahashi, Tsutomu Endo, Tomohiro Onodera, Ken Kadoya, Norimasa Iwasaki
Publikováno v:
Arthritis & Rheumatology.
Autor:
Gen Matsumae, Mohamad Alaa Terkawi, Takayuki Nonoyama, Takayuki Kurokawa, Daisuke Takahashi, Tomohiro Shimizu, Ken Kadoya, Jian Ping Gong, Kazunori Yasuda, Norimasa Iwasaki
Publikováno v:
Biomaterials Science. 10:2182-2187
Double network hydrogels have been proven to be a substitute biomaterial for cartilage. For further applications as articular cartilages, it is essential to understand the biological reactions that might be initiated by their micro-particles.
Autor:
Yuki Matsui, Ken Kadoya, Yusuke Nagano, Takeshi Endo, Masato Hara, Gen Matsumae, Tomoaki Suzuki, Yasuhiro Yamamoto, Mohamad Alaa Terkawi, Norimasa Iwasaki
Publikováno v:
Cellular and Molecular Life Sciences. 79
Accumulating evidences suggest that M2 macrophages are involved with repair processes in the nervous system. However, whether M2 macrophages can promote axon regeneration by directly stimulating axons nor its precise molecular mechanism remains elusi