Therapeutic Effect of IL-21 Blockage by Gene Therapy in Experimental Autoimmune Encephalomyelitis

Autor: Ángel Edo, Laura Calvo-Barreiro, Herena Eixarch, Assumpció Bosch, Miguel Chillón, Carmen Espejo

Publikováno v: Scientia

Soluble receptor; Multiple sclerosis Receptor soluble; Esclerosis múltiple Receptor soluble; Esclerosi múltiple The pathogenic role of the interleukin 21 (IL-21) in different autoimmune diseases, such as multiple sclerosis (MS), has been extensivel

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https://doi.org/10.1007/s13311-022-01279-8

Variation of the clinical spectrum and genotype-phenotype associations in Coenzyme Q10 deficiency associated glomerulopathy

Autor: Stefania Drovandi, Beata S. Lipska-Ziętkiewicz, Fatih Ozaltin, Francesco Emma, Bora Gulhan, Olivia Boyer, Agnes Trautmann, Szymon Ziętkiewicz, Hong Xu, Qian Shen, Jia Rao, Korbinian M. Riedhammer, Uwe Heemann, Julia Hoefele, Sarah L. Stenton, Alexey N. Tsygin, Kar-Hui Ng, Svitlana Fomina, Elisa Benetti, Manon Aurelle, Larisa Prikhodina, Anne M. Schijvens, Mansoureh Tabatabaeifar, Maciej Jankowski, Sergey Baiko, Jianhua Mao, Chunyue Feng, Fang Deng, Caroline Rousset-Rouviere, Małgorzata Stańczyk, Irena Bałasz-Chmielewska, Marc Fila, Anne M. Durkan, Tanja Kersnik Levart, Ismail Dursun, Nasrin Esfandiar, Dorothea Haas, Anna Bjerre, Ali Anarat, Marcus R. Benz, Saeed Talebi, Nakysa Hooman, Gema Ariceta, Franz Schaefer, Lina Maria Serna Higuita, Alaleh Gheissari, Nazym Nigmatullina, Marcin Tkaczyk, Halina Borzecka, Radovan Bogdanovic, Sevgi Mir, Thomas Klopstock, Holger Prokisch, Cornelia Kornblum, Cui-Hua Liu, Shu-Zhen Sun, Yang Dong, Xiao-Wen Wang, Jiang-Wei Luan

Publikováno v: Kidney Int. 102, 592-603 (2022)
Scientia

Coenzyme Q10; Mitochondria; Steroid-resistant nephrotic syndrome Coenzima Q10; Mitocondrias; Síndrome nefrótico resistente a los esteroides Coenzim Q10; Mitocondris; Síndrome nefròtic resistent als esteroides Primary Coenzyme Q10 deficiency is a

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http://hdl.handle.net/10852/99032

MYC inhibitors in multiple myeloma

Autor: Laura Soucek, Sandra Martínez-Martín

Publikováno v: Scientia

MYC inhibition; Targeted therapies; Epigenetics Inhibición de MYC; Terapias dirigidas; Epigenética Inhibició de MYC; Teràpies dirigides; Epigenètica The importance of MYC function in cancer was discovered in the late 1970s when the sequence of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c367ecbbb58c26579c14849d90f6a5
https://hdl.handle.net/11351/7751

Genetic association study of childhood aggression across raters, instruments, and age

Autor: Nicholas G. Martin, S. Alexandra Burt, Louise Arseneault, Fazil Aliev, Luke M. Evans, Hill F. Ip, Beate St Pourcain, Michel G. Nivard, William E. Copeland, Rebecca K. Vinding, Scott Gordon, Koen Bolhuis, Christian J. Hopfer, Gun Peggy Knudsen, Stefan Johansson, Avshalom Caspi, Richard Border, Chandra A. Reynolds, Pål R. Njølstad, Liisa Keltikangas-Järvinen, Dorret I. Boomsma, Klaus Bønnelykke, Teemu Palviainen, Marta Ribasés, Alina Rodriguez, Catharina A. Hartman, Ilkka Seppälä, Christel M. Middeldorp, Rosa Bosch, Jan Haavik, Gail M. Williams, Andrea G. Allegrini, Ruth Ks, John R. B. Perry, Hadi Zafarmand, Chang Jiang, Elizabeth J. Costello, Camiel M. van der Laan, Olli T. Raitakari, Miquel Casas, Isabell Brikell, William G. Iacono, Jaakko Kaprio, John K. Hewitt, Andrew C. Heath, Eero Vuoksimaa, Xiaoran Tong, Gemma Español, Erik A. Ehli, Richie Poulton, Gareth E. Davies, Albertine J. Oldehinkel, Hans Bisgaard, Naomi R. Wray, Ted Reichborn-Kjennerud, Robert Plomin, Michael C. Stallings, Qing Lu, Jackob M. Najman, Daniel E. Adkins, Yi Lu, Harold Snieder, Sally J. Wadsworth, Alexander Neumann, Alexandra Havdahl, Karen Sugden, Kelly L. Klump, Andrew Smolen, Henrik Larsson, Toos C. E. M. van Beijsterveldt, Kenneth Krauter, Tarunveer S. Ahluwalia, Tellervo Korhonen, Andrey A. Shabalin, Joachim Heinrich, Anke R. Hammerschlag, Shelby Marrington, Lærke Sass, Pamela A. F. Madden, Henning Tiemeier, Tanja Vrijkotte, Paul Lichtenstein, Terho Lehtimäki, Ville Karhunen, Cristina Sánchez-Mora, Robin P. Corley, Anna A. E. Vinkhuyzen, Richard J. Rose, Per Magnus, Sabrina Llop, Ilja M. Nolte, S.A. Brown, Christian Hakulinen, Anjali K. Henders, Marie Standl, Silvia Alemany, Gretchen R.B. Saunders, Jouke-Jan Hottenga, Eveline L. de Zeeuw, Meike Bartels, Elisabeth Thiering, José J. Morosoli, Fiona A. Hagenbeek, Laura Pulkki-Råback, Frank C. Verhulst, Martin A. Kennedy, Craig E. Pennell, Eva Krapohl, Kaili Rimfeld, Tetyana Zayats, Lucía Colodro-Conde, Judith B.M. Ensink, André G. Uitterlinden, Natalia Vilor-Tejedor, Felix R. Day, Jennifer R. Harris, George Davey Smith, Qi Chen, Sebastian Lundström, Marjo-Riitta Järvelin, Alyce M. Whipp, Katrina L. Grasby, L. John Horwood, John Pearson, Judy L. Silberg, Paula Rovira, Hermine H. Maes, Carol A. Wang, Roseann E. Peterson, Tamara L. Wall, Andrew J. O. Whitehouse, Maria-Jose Lopez-Espinosa, Najaf Amin, Jess Tyrrell, Danielle M. Dick, Sarah E. Medland, Allison L. Miller, Øyvind Helgeland, Josep Antoni Ramos Quiroga, Joseph M. Boden, Abdullah Mamun, James Scott, María Soler Artigas, Joseph A. Prinz, Lindon J. Eaves, Terrie E. Moffitt, Matt McGue, Jordi Sunyer, Joanna Martin

Publikováno v: Ip, H F, van der Laan, Camiel, C, Krapohl, E, Brikell, I, Sánchez-Mora, C, Nolte, I M, St Pourcain, M U B, Bolhuis, K, Palviainen, T & Davey Smith, G 2021, ' Genetic Association Study of Childhood Aggression across raters, instruments and age ', Translational Psychiatry, vol. 11, no. 1, 413 . https://doi.org/10.1038/s41398-021-01480-x
Translational Psychiatry
Translational Psychiatry, 11(1), 1-9. Nature Publishing Group
Translational Psychiatry, 11, 1, pp. 1-9
Ip, H F, van der Laan, C M, Krapohl, E M L, Brikell, I, Sánchez-Mora, C, Nolte, I M, St Pourcain, B, Bolhuis, K, Palviainen, T, Zafarmand, H, Colodro-Conde, L, Gordon, S, Zayats, T, Aliev, F, Jiang, C, Wang, C A, Saunders, G, Karhunen, V, Hammerschlag, A R, Adkins, D E, Border, R, Peterson, R E, Prinz, J A, Thiering, E, Seppälä, I, Vilor-Tejedor, N, Ahluwalia, T S, Day, F R, Hottenga, J J, Allegrini, A G, Rimfeld, K, Chen, Q, Lu, Y, Martin, J, Soler Artigas, M, Rovira, P, Bosch, R, Español, G, Ramos Quiroga, J A, Neumann, A, Ensink, J, Grasby, K, Morosoli, J J, Tong, X, Marrington, S, Middeldorp, C, Scott, J G, Vinkhuyzen, A, Shabalin, A A, Corley, R, Evans, L M, Sugden, K, Alemany, S, Sass, L, Vinding, R, Ruth, K, Tyrrell, J, Davies, G E, Ehli, E A, Hagenbeek, F A, De Zeeuw, E, Van Beijsterveldt, T C E M, Larsson, H, Snieder, H, Verhulst, F C, Amin, N, Whipp, A M, Korhonen, T, Vuoksimaa, E, Rose, R J, Uitterlinden, A G, Heath, A C, Madden, P, Haavik, J, Harris, J R, Helgeland, Ø, Johansson, S, Knudsen, G P S, Njolstad, P R, Lu, Q, Rodriguez, A, Henders, A K, Mamun, A, Najman, J M, Brown, S, Hopfer, C, Krauter, K, Reynolds, C, Smolen, A, Stallings, M, Wadsworth, S, Wall, T L, Silberg, J L, Miller, A, Keltikangas-Järvinen, L, Hakulinen, C, Pulkki-Råback, L, Havdahl, A, Magnus, P, Raitakari, O T, Perry, J R B, Llop, S, Lopez-Espinosa, M J, Bønnelykke, K, Bisgaard, H, Sunyer, J, Lehtimäki, T, Arseneault, L, Standl, M, Heinrich, J, Boden, J, Pearson, J, Horwood, L J, Kennedy, M, Poulton, R, Eaves, L J, Maes, H H, Hewitt, J, Copeland, W E, Costello, E J, Williams, G M, Wray, N, Järvelin, M R, McGue, M, Iacono, W, Caspi, A, Moffitt, T E, Whitehouse, A, Pennell, C E, Klump, K L, Burt, S A, Dick, D M, Reichborn-Kjennerud, T, Martin, N G, Medland, S E, Vrijkotte, T, Kaprio, J, Tiemeier, H, Davey Smith, G, Hartman, C A, Oldehinkel, A J, Casas, M, Ribasés, M, Lichtenstein, P, Lundström, S, Plomin, R, Bartels, M, Nivard, M G & Boomsma, D I 2021, ' Genetic association study of childhood aggression across raters, instruments, and age ', Translational Psychiatry, vol. 11, no. 1, 413 . https://doi.org/10.1038/s41398-021-01480-x
Translational Psychiatry, 11(1):413. Nature Publishing Group
TRANSLATIONAL PSYCHIATRY
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Transl. Psychiatry 11:413 (2021)
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational psychiatry, 11(1):413. Nature Publishing Group
Scientia
Translational Psychiatry, 11, 1-9
Translational Psychiatry, 11(1):413, 1-9. Nature Publishing Group
Ip, H F, van der Laan, C M, Krapohl, E M L, Brikell, I, Sánchez-Mora, C, Nolte, I M, St Pourcain, B, Bolhuis, K, Palviainen, T, Zafarmand, H, Colodro-Conde, L, Gordon, S, Zayats, T, Aliev, F, Jiang, C, Wang, C A, Saunders, G, Karhunen, V, Hammerschlag, A R, Adkins, D E, Border, R, Peterson, R E, Prinz, J A, Thiering, E, Seppälä, I, Vilor-Tejedor, N, Ahluwalia, T S, Day, F R, Hottenga, J-J, Allegrini, A G, Rimfeld, K, Chen, Q, Lu, Y, Martin, J, Soler Artigas, M, Rovira, P, Bosch, R, Español, G, Ramos Quiroga, J A, Neumann, A, Ensink, J, Grasby, K, Morosoli, J J, Tong, X, Marrington, S, Middeldorp, C, Scott, J G, Vinkhuyzen, A, Shabalin, A A, Corley, R, Evans, L M, Sugden, K, Alemany, S, Sass, L, Vinding, R, Ruth, K, Tyrrell, J, Davies, G E, Ehli, E A, Hagenbeek, F A, De Zeeuw, E, Van Beijsterveldt, T C E M, Larsson, H, Snieder, H, Verhulst, F C, Amin, N, Whipp, A M, Korhonen, T, Vuoksimaa, E, Rose, R J, Uitterlinden, A G, Heath, A C, Madden, P, Haavik, J, Harris, J R, Helgeland, Ø, Johansson, S, Knudsen, G P S, Njolstad, P R, Lu, Q, Rodriguez, A, Henders, A K, Mamun, A, Najman, J M, Brown, S, Hopfer, C, Krauter, K, Reynolds, C, Smolen, A, Stallings, M, Wadsworth, S, Wall, T L, Silberg, J L, Miller, A, Keltikangas-Järvinen, L, Hakulinen, C, Pulkki-Råback, L, Havdahl, A, Magnus, P, Raitakari, O T, Perry, J R B, Llop, S, Lopez-Espinosa, M-J, Bønnelykke, K, Bisgaard, H, Sunyer, J, Lehtimäki, T, Arseneault, L, Standl, M, Heinrich, J, Boden, J, Pearson, J, Horwood, L J, Kennedy, M, Poulton, R, Eaves, L J, Maes, H H, Hewitt, J, Copeland, W E, Costello, E J, Williams, G M, Wray, N, Järvelin, M-R, McGue, M, Iacono, W, Caspi, A, Moffitt, T E, Whitehouse, A, Pennell, C E, Klump, K L, Burt, S A, Dick, D M, Reichborn-Kjennerud, T, Martin, N G, Medland, S E, Vrijkotte, T, Kaprio, J, Tiemeier, H, Davey Smith, G, Hartman, C A, Oldehinkel, A J, Casas, M, Ribasés, M, Lichtenstein, P, Lundström, S, Plomin, R, Bartels, M, Nivard, M G & Boomsma, D I 2021, ' Genetic association study of childhood aggression across raters, instruments, and age ', Translational Psychiatry, vol. 11, no. 1, 413, pp. 1-9 . https://doi.org/10.1038/s41398-021-01480-x

Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15e2fef49a22c3e1eab3b8843c8b2ac
https://trepo.tuni.fi/handle/10024/133797

Gene therapy for neuronopathic mucopolysaccharidoses : state of the art

Autor: María José de Castro, Roberto Giugliani, Mireia del Toro, María L. Couce

Publikováno v: Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
International Journal of Molecular Sciences, Vol 22, Iss 9200, p 9200 (2021)
International Journal of Molecular Sciences
Scientia

Virus adeno associat; Lentivirus; Vectors virals Virus adenoasociado; Lentivirus; Vectores virales Adeno-associated virus; Lentivirus; Viral vectors The need for long-lasting and transformative therapies for mucopolysaccharidoses (MPS) cannot be unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e2475541d031d1db3e41a14ca60458