Chemical and biological assessment of metal organic frameworks (MOFs) in pulmonary cells and in an acute in vivo model: relevance to pulmonary arterial hypertension therapy

Autor: Magdi H. Yacoub, Daniel Morales-Cano, Bianca Barreira, Peter M. George, Gemma R. Freeman, Nicholas S. Kirkby, Nura A. Mohamed, Laura Moreno, Teresa D. Tetley, Jane A. Mitchell, Adrian H. Chester, Blerina Ahmetaj-Shala, Hime Gashaw, Stephen J. Wort, Robert P. Davies, Daniel M. Reed, Paul D. Lickiss, Hira Saleem

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Pulmonary Circulation

Pulmonary arterial hypertension (PAH) is a progressive and debilitating condition. Despite promoting vasodilation, current drugs have a therapeutic window within which they are limited by systemic side effects. Nanomedicine uses nanoparticles to impr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b50a86c1446ca0b8b7b33671e6216c
https://doi.org/10.1177/2045893217710224

Platinum(II) Complexes of N∧C∧N-Coordinating 1,3-Bis(2-pyridyl)benzene Ligands: Thiolate Coligands Lead to Strong Red Luminescence from Charge-Transfer States

Autor: Gemma R. Freeman, William A. Tarran, Lisa Murphy, Ritu Kataky, Adam M. Benham, J. A. Gareth Williams

Publikováno v: Inorganic Chemistry. 53:5738-5749

A new family of platinum(II) complexes of the form PtL(n)SR have been prepared, where L(n) represents a cyclometalating, N^C^N-bound tridentate ligand and SR is a monodentate thiolate ligand. The complexes fall into two groups, those of PtL(1)SR wher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93cb9522c2eb2709face5ab05cb08eb1
https://doi.org/10.1021/ic500555w

Metal Organic Framework as a Potential Drug Carrier for Pulmonary Arterial Hypertension

Autor: Bianca Barreira Barba, Daniel M. Reed, Peter M. George, Hira Saleem, Gemma R. Freeman, Jane A. Mitchell, Magdi H. Yacoub, Paul D. Lickiss, John Wort, Robert P. Davies, Daniel García-Ruiz de Morales, Laura Moreno Gutierrez, Nura A. Mohamed, Adrian H. Chester

Publikováno v: Qatar Foundation Annual Research Conference Proceedings Volume 2016 Issue 1.

Pulmonary arterial hypertension (PAH) is a progressive, debilitating and fatal condition [1]. Current PAH therapy relies on vasodilator drugs, which are seriously limited by their systemic side effects. We suggest that advances made in the field of n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03efc4f37985be403662c7505ba9a1af
https://doi.org/10.5339/qfarc.2016.hbsp2477

An unprecedented cyclometallated platinum(II) complex incorporating a phosphinine co-ligand: synthesis and photoluminescence behaviour

Autor: Gemma R. Freeman, Lise-Marie Chamoreau, Jamal Moussa, Hani Amouri, Thomas Cheminel, J. A. Gareth Williams

Publikováno v: Dalton transactions, 2014, Vol.43(22), pp.8162-8165 [Peer Reviewed Journal]

The first luminescent cyclometallated platinum(II) complex bearing phosphinine co-ligands is reported. The long-lived luminescence, which it displays at 77 K, is assigned to a phosphinine-localised triplet excited state on the basis of electrochemica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4638cde342d84c92f64a0272f6d9ca03
https://pubmed.ncbi.nlm.nih.gov/24718441

ChemInform Abstract: Aqueous Methods for the Preparation of 5′-Substituted Guanosine Derivatives

Autor: Gemma R. Freeman, Mark C. Shankey, Milena Trmčić, Paul Brear, David R. W. Hodgson

Publikováno v: ChemInform. 41

We have developed simple, aqueous strategies, that avoid the use of protecting groups and chromatography, for the preparation of a series of 5'-substituted guanosine derivatives.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3bc195fc886fe6dbd613d15f9b90cd4
https://doi.org/10.1002/chin.201001208