Intrathecal administration of IGF-I by AAVrh10 improves sensory and motor deficits in a mouse model of diabetic neuropathy

Autor: Judit Homs, Gemma Pagès, Lorena Ariza, Caty Casas, Miguel Chillón, Xavier Navarro, Assumpció Bosch

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)

Different adeno-associated virus (AAV) serotypes efficiently transduce neurons from central and peripheral nervous systems through various administration routes. Direct administration of the vectors to the cerebrospinal fluid (CSF) could be an effici

Externí odkaz: https://doaj.org/article/5c8bb3bb4c094646ac916bdbedb6acfb

Specific Expression of Glial-Derived Neurotrophic Factor in Muscles as Gene Therapy Strategy for Amyotrophic Lateral Sclerosis

Autor: Belén García-Lareu, Assumpció Bosch, Rubèn López-Vales, Xavier Navarro, Sergi Verdés, Miguel Chillón, Gemma Pagès, Mireia Herrando-Grabulosa, Guillem Mòdol-Caballero

Publikováno v: Neurotherapeutics

Glial cell line–derived neurotrophic factor (GDNF) is a powerful neuroprotective growth factor. However, systemic or intrathecal administration of GDNF is associated with side effects. Here, we aimed to avoid this by restricting the transgene expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a20c5886138274dbec136fc5778985
https://pubmed.ncbi.nlm.nih.gov/33786805

AAVrh.10 immunogenicity in mice and humans. Relevance of antibody cross-reactivity in human gene therapy

Autor: Assumpció Bosch, Rosemary Thwaite, Gemma Pagès, Miguel Chillón

Publikováno v: Gene therapy. 22(2)

Simian adeno-associated virus (AAV) serotype rh.10 is a promising gene therapy tool, achieving safe, sustained transgene expression in the nervous system, lung, liver and heart in animal models. To date, preexisting immunity in humans has not been co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a4c03ea8972aa3a6f509ef817ad89a
https://pubmed.ncbi.nlm.nih.gov/25410741

Central nervous system delivery of helper-dependent canine adenovirus corrects neuropathology and behavior in mucopolysaccharidosis type VII mice

Autor: Lorena Ariza, Lydia Giménez-Llort, Assumpció Bosch, Dan Cots, Eric J. Kremer, Belén García-Lareu, Aurélie Cubizolle, Gemma Pagès, Rosemary Thwaite, Miguel Chillón, Nicolas Serratrice

Publikováno v: Human Gene Therapy
Human Gene Therapy, 2014, 25 (3), pp.199--211. ⟨10.1089/hum.2013.152⟩
Human Gene Therapy, Mary Ann Liebert, 2014, 25 (3), pp.199--211. ⟨10.1089/hum.2013.152⟩

International audience; Canine adenovirus type 2 vectors (CAV-2) are promising tools to treat global central nervous system (CNS) disorders due to their preferential transduction of neurons and efficient retrograde axonal transport. Here we tested th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::516e66bf8defe1b279b6425a10c179f4
https://hal.science/hal-02191549

Intrathecal administration of IGF-I by AAVrh10 improves sensory and motor deficits in a mouse model of diabetic neuropathy

Autor: Caty Casas, Assumpció Bosch, Xavier Navarro, Judit Homs, Lorena Ariza, Gemma Pagès, Miguel Chillón

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Molecular Therapy. Methods & Clinical Development

Altres ajuts: G.P. and L.A. from the Generalitat de Catalunya: 2009FI_B00219 and 2006FI00762, respectively). A.B. was a beneficiary of the Ramon y Cajal Program. This work was supported by the Marató TV3 (110432 to A.B. and C.C.) and the UAB (EME04-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4451fc565edf869ff7d1ad266e2a5d7
https://doi.org/10.1038/mtm.2013.7