CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome

Autor: Jennifer Jungfleisch, René Böttcher, Marc Talló-Parra, Gemma Pérez-Vilaró, Andres Merits, Eva Maria Novoa, Juana Díez

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Viruses completely depend on the host translational machinery, but their genomes are often enriched in rare codons and therefore should be translated with poor efficiency. Here, Jungfleisch et al. apply Ribo-Seq and RNASeq to provide a global view on

Externí odkaz: https://doaj.org/article/cd415b25962d44179dcc92cd3f328cfa

Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity

Autor: Gemma Pérez-Vilaró, Miguel A. Valverde, Pablo Doñate-Macian, Fanny Rubio-Moscardo, Yorley Duarte, Jonathan Canan, Fernando D. González-Nilo, Juana Díez

Publikováno v: British Journal of Pharmacology. 179:3576-3591

Background and purpose: The transient receptor potential vanilloid 4 (TRPV4) cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting pharmacological target with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90733d8ee913196b41be386cc9c917c6
https://doi.org/10.1111/bph.15267

Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection

Autor: Juan Pablo Horcajada, Marina Vogel-González, Natalia Garcia-Giralt, Maria Luisa Sorli-Redó, Robert Güerri-Fernández, Marc Talló-Parra, Silvia Gómez-Zorrilla, Xavier Nogués, Miguel Chillón, Isabel Arnau-Barrés, Inmaculada López-Montesinos, Julio Pascual, Rubén Vicente, Gemma Pérez-Vilaró, Víctor Herrera-Fernández, Juana Díez

Publikováno v: Scientia
Nutrients, Vol 13, Iss 562, p 562 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Nutrients
Volume 13
Issue 2

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Resultats clínics; Zinc Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Resultados clínicos; Zinc Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Clinical outcomes; Zinc Background: Zinc is an essential micron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419ba4c3bc432f59fc3ea91f3d501a14
https://hdl.handle.net/11351/6175

Low Zinc Levels at Clinical Admission Associates with Poor Outcomes in COVID-19

Autor: Luisa Sorlí-Redó, Natalia Garcia-Giralt, Víctor Herrera-Fernández, Robert Güerri-Fernández, Julio Pascual, Marina Vogel-González, Marc Talló-Parra, Rubén Vicente, Gemma Pérez-Vilaró, Judit Villar, Miguel Chillón, Inmaculada López-Montesinos, Juana Díez, Xavier Nogués, Juan Pablo Horcajada, Silvia Gómez-Zorrilla

Publikováno v: SSRN Electronic Journal.

Background: Biomarkers to predict Coronavirus disease-19 (COVID-19) outcome early at infection are urgently needed to improve prognosis and treatment. Zinc balances immune responses and also has a proven direct antiviral action against some viruses.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::589e42d948ed09822acc84b1085ee386
https://doi.org/10.2139/ssrn.3696880

The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity

Autor: Francisca Rubio-Moscardo, Alex Perálvarez-Marín, Miguel A. Valverde, Gemma Pérez-Vilaró, Jennifer Jungfleisch, Juana Díez, Pau Doñate-Macián

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname

Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the TRPV4 cation channel binds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05314580fc6758eecbd7ca8f89b00cea
https://doi.org/10.1038/s41467-018-04776-7