The ATR inhibitor ceralasertib potentiates cancer checkpoint immunotherapy by regulating the tumor microenvironment

Autor: Elizabeth L. Hardaker, Emilio Sanseviero, Ankur Karmokar, Devon Taylor, Marta Milo, Chrysis Michaloglou, Adina Hughes, Mimi Mai, Matthew King, Anisha Solanki, Lukasz Magiera, Ricardo Miragaia, Gozde Kar, Nathan Standifer, Michael Surace, Shaan Gill, Alison Peter, Sara Talbot, Sehmus Tohumeken, Henderson Fryer, Ali Mostafa, Kathy Mulgrew, Carolyn Lam, Scott Hoffmann, Daniel Sutton, Larissa Carnevalli, Fernando J. Calero-Nieto, Gemma N. Jones, Andrew J. Pierce, Zena Wilson, David Campbell, Lynet Nyoni, Carla P. Martins, Tamara Baker, Gilberto Serrano de Almeida, Zainab Ramlaoui, Abdel Bidar, Benjamin Phillips, Joseph Boland, Sonia Iyer, J. Carl Barrett, Arsene-Bienvenu Loembé, Serge Y. Fuchs, Umamaheswar Duvvuri, Pei-Jen Lou, Melonie A. Nance, Carlos Alberto Gomez Roca, Elaine Cadogan, Susan E. Critichlow, Steven Fawell, Mark Cobbold, Emma Dean, Viia Valge-Archer, Alan Lau, Dmitry I. Gabrilovich, Simon T. Barry

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract The Ataxia telangiectasia and Rad3-related (ATR) inhibitor ceralasertib in combination with the PD-L1 antibody durvalumab demonstrated encouraging clinical benefit in melanoma and lung cancer patients who progressed on immunotherapy. Here we

Externí odkaz: https://doaj.org/article/189773f2417346dcbdf8b6281d57effa

Reliability and Measurement Error of the Qualitative Analysis of Single Leg Loading (QASLS) Tool For Unilateral Tasks

Autor: Gemma N Parry, Lee C Herrington, Allan G Munro

Publikováno v: International Journal of Sports Physical Therapy, Vol 18, Iss 5 (2023)

# Background Movement quality assessment is popular within clinical and sporting practice, due to the contribution diminished or suboptimal movement quality is believed to have on musculoskeletal (MSK) injury risk. Various movement quality assessmen

Externí odkaz: https://doaj.org/article/ad93d39b36f4437386b639d0edbb5bff

Effects of temperature and photoperiod on the seasonal timing of Western honey bee colonies and an early spring flowering plant

Autor: Gemma N. Villagomez, Fabian Nürnberger, Fabrice Requier, Susanne Schiele, Ingolf Steffan‐Dewenter

Publikováno v: Ecology and Evolution, Vol 11, Iss 12, Pp 7834-7849 (2021)

Abstract Temperature and photoperiod are important Zeitgebers for plants and pollinators to synchronize growth and reproduction with suitable environmental conditions and their mutualistic interaction partners. Global warming can disturb this tempora

Externí odkaz: https://doaj.org/article/1cf4f1a863234c8db82ea99eb1b456bd

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The Use of Biologic Mesh for Repair of Perianal Fistulas.

Autor: Gemma N; General Surgery, Summa Health, Akron, USA., McMahon K; General Surgery, Summa Health, Akron, USA., Clapp M; General Surgery, Summa Health, Akron, USA., Ma T; Surgery, Summa Health, Akron, USA., Laipply E; Colorectal Surgery, Summa Health, Akron, USA.

Publikováno v: Cureus [Cureus] 2024 Jul 16; Vol. 16 (7), pp. e64675. Date of Electronic Publication: 2024 Jul 16 (Print Publication: 2024).