Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease

Autor: Clelia Tiziana Storlazzi, Giovanni Martinelli, Debora Traversa, Gemma Macchia, Lasse Sommer Kristensen, Doron Tolomeo, Giorgia Simonetti, Martina Ghetti, Grazia Visci

Publikováno v: Traversa, D, Simonetti, G, Tolomeo, D, Visci, G, Macchia, G, Ghetti, M, Martinelli, G, Kristensen, L S & Storlazzi, C T 2022, ' Unravelling similarities and differences in the role of circular and linear PVT1 in cancer and human disease ', British Journal of Cancer, vol. 126, no. 6, pp. 835-850 . https://doi.org/10.1038/s41416-021-01584-7

The plasmacytoma variant translocation 1 (PVT1) is a long non-coding RNA gene involved in human disease, mainly in cancer onset/progression. Although widely analysed, its biological roles need to be further clarified. Notably, functional studies on P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0222a5be3471a803ce199dcad60f9c8
https://doi.org/10.1038/s41416-021-01584-7

BL1391: an established cell line from a human malignant peripheral nerve sheath tumor with unique genomic features

Autor: Doron, Tolomeo, Antonio, Agostini, Gemma, Macchia, Alberto, L'Abbate, Marco, Severgnini, Ingrid, Cifola, Maria Antonia, Frassanito, Vito, Racanelli, Antonio Giovanni, Solimando, Felix, Haglund, Fredrik, Mertens, Clelia Tiziana, Storlazzi

Publikováno v: Human cell. 34(1)

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive tumors, accounting for around 5% of all soft tissue sarcomas. A better understanding of the pathogenesis of these tumors and the development of effective treatments are needed. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a6a075083bc7067b32891a5c8b686b78
https://pubmed.ncbi.nlm.nih.gov/32856169

Concurrent chromothripsis events in a case of TP53 depleted acute myeloid leukemia with myelodysplasia-related changes

Autor: Massimo Carella, C. Lo Cunsolo, Clelia Tiziana Storlazzi, Doron Tolomeo, Giovanni Martinelli, Pietro D'Addabbo, Gemma Macchia, Tommaso Mazza, P. Iuzzolino, Emanuela Ottaviani, Alberto L'Abbate, Orazio Palumbo, M.F. Miccoli, Vito Racanelli, Angelo Lonoce

Publikováno v: Cancer genetics. 237

Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous hematological disorder defined by morphological, genetic, and clinical features. Patients with AML-MRC often show cytogenetic changes, which are associated with p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d77d04fe0d2af3dd8020a12d9341d935
https://pubmed.ncbi.nlm.nih.gov/31447067

The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer

Autor: Gemma Macchia, Clelia Tiziana Storlazzi, Doron Tolomeo, Ingrid Cifola, Alberto L'Abbate, Fredrik Mertens, Hilen Casciaro, Gianluca De Bellis, Orazio Palumbo, Marco Severgnini, Stefania Purgato, Laurence Bianchini, Giovanni Perini, Anna Loverro, Massimo Carella, Mariano Rocchi

Publikováno v: Genetics (Austin Tex., Online) 208 (2018): 951–961. doi:10.1534/genetics.117.300552
info:cnr-pdr/source/autori:Gemma Macchia, Marco Severgnini, Stefania Purgato, Doron Tolomeo, Hilen Casciaro, Ingrid Cifola, Alberto L'Abbate, Anna Loverro, Orazio Palumbo, Massimo Carella, Laurence Bianchini, Giovanni Perini, Gianluca De Bellis, Fredrik Mertens, Mariano Rocchi and Clelia T. Storlazzi/titolo:The Hidden Genomic and Transcriptomic Plasticity of Giant Marker Chromosomes in Cancer/doi:10.1534%2Fgenetics.117.300552/rivista:Genetics (Austin Tex., Online)/anno:2018/pagina_da:951/pagina_a:961/intervallo_pagine:951–961/volume:208

Neocentromeres contribute to cancer progression by mitotically stabilizing acentric chromosomes containing amplified oncogenes. Macchia et al. show that... Genome amplification in the form of rings or giant rod-shaped marker chromosomes (RGMs) is a c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621304e245443fa6669e2df2f56f7be7
https://pubmed.ncbi.nlm.nih.gov/29279323

Genomic organization and evolution of double minutes/homogeneously staining regions withMYCamplification in human cancer

Autor: Martin Dugas, Gianluca De Bellis, Angelo Lonoce, Ingrid Cifola, Gemma Macchia, Doron Tolomeo, Domenico Trombetta, Christopher W. Whelan, Marco Severgnini, Pietro D'Addabbo, Christoph Bartenhagen, Klaas Kok, Alberto L'Abbate, Lucia Carbone, Massimo Carella, Orazio Palumbo, Mariano Rocchi, Clelia Tiziana Storlazzi

Publikováno v: Nucleic Acids Research
Web of Science
Nucleic acids research 42 (2014): 9131–9145. doi:10.1093/nar/gku590
info:cnr-pdr/source/autori:L'Abbate, Alberto; Macchia, Gemma; D'Addabbo, Pietro; Lonoce, Angelo; Tolomeo, Doron; Trombetta, Domenico; Kok, Klaas; Bartenhagen, Christoph; Whelan, Christopher W.; Palumbo, Orazio; Severgnini, Marco Centanni Marco; Cifola, Ingrid; Dugas, Martin; Carella, Massimo; De Bellis, Gianluca; Rocchi, Mariano; Carbone, Lucia; Storlazzi, C. T./titolo:Genomic organization and evolution of double minutes%2Fhomogeneously staining regions with MYC amplification in human cancer/doi:10.1093%2Fnar%2Fgku590/rivista:Nucleic acids research/anno:2014/pagina_da:9131/pagina_a:9145/intervallo_pagine:9131–9145/volume:42
Nucleic Acids Research, 42(14), 9131-9145. Oxford University Press

The mechanism for generating double minutes chromosomes (dmin) and homogeneously staining regions (hsr) in cancer is still poorly understood. Through an integrated approach combining nextgeneration sequencing, single nucleotide polymorphism array, fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20faef3ec3cc013e49398f919e181948
https://doi.org/10.1093/nar/gku590