Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Gemma M.A. Gregg"'
Autor:
Kirsty M. McLaughlin, Tamas Sessler, Peter Gallagher, Emma M. Kerr, Wendy L. Allen, Alexander J. McIntyre, Gemma M.A. Gregg, Vicky M. Coyle, Gerard P. Quinn, Melissa Labonte-Wilson, Nyree Crawford, Daniel B. Longley, Jamie Z. Roberts, Andrea Lees, Fiammetta Falcone, Mark Wappett, Patrick G. Johnston, Christopher McCann, Katherine McAllister, Caitriona Holohan, Laurence J. Egan, Aideen E. Ryan, Philip D Dunne, Simon S. McDade
Publikováno v:
Lees, A, McIntyre, A J, Crawford, N T, Falcone, F, McCann, C, Holohan, C, Quinn, G P, Roberts, J Z, Sessler, T, Gallagher, P F, Gregg, G M A, McAllister, K, McLaughlin, K M, Allen, W L, Egan, L J, Ryan, A E, Labonte-Wilson, M J, Dunne, P D, Wappett, M, Coyle, V M, Johnston, P G, Kerr, E M, Longley, D B & McDade, S S 2020, ' The pseudo-caspase FLIP(L) regulates cell fate following p53 activation ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 30, pp. 17808–17819 . https://doi.org/10.1073/pnas.2001520117
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the molecular basis of the switch from p53-induced cell-cycle arrest to apoptosis remains poorly understood. Using a combination of transcriptomics and functional genomics, w
Autor:
Vicky M. Coyle, Simon S. McDade, Laurence J. Egan, Aideen E. Ryan, Katherine McAllister, Phillip D. Dunne, Andrea Lees, Peter Gallagher, Christopher McCann, Gemma M.A. Gregg, Tamas Sessler, Daniel B. Longley, Jamie Z. Roberts, Wendy L. Allen, Nyree Crawford, Emma M. Kerr, Mark Wappett, Patrick G. Johnston, Kirsty M. McLaughlin, Melissa Labonte-Wilson, Alexander J. McIntyre, Caitriona Holohan, Fiammetta Falcone, Gerard P. Quinn
How p53 differentially activates cell cycle arrest versus cell death remains poorly understood. Here, we demonstrate that upregulation of canonical pro-apoptotic p53 target genes in colon cancer cells imposes a critical dependence on the long splice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0611e428fef38e39ea43e58a06022cb5
Autor:
P.G. Johnston, Vicky M. Coye, Emma M. Kerr, Peter Gallagher, Phillip D. Dunne, Fiammetta Falcone, Caitriona Holohan, Simon S. McDade, Alexander J. McIntyre, Andrea Lees, Laurence J. Egan, Gemma M.A. Gregg, Aideen E. Ryan, Nyree Crawford, Wendy L. Allen, Chris McCann, Thomas Sessler, Katherine McAllister, Daniel B. Longley, Jamie Z. Roberts, Melissa Labonte-Wilson, Gerard P. Quinn, Mark Wappett, Kirsty M. McLaughlin
Publikováno v:
Cancer Research. 80:2409-2409
Background: How p53 differentially activates cell cycle arrest versus cell death remains poorly understood. Understanding the mechanisms governing the switch from p53-induced cell-fates is important for optimising efficacy of p53-activating therapies
Autor:
Gemma M.A. Gregg, Ian I. Mills, Richard D. Kennedy, Peter T. Gallagher, Gerard P. Quinn, Fiammetta Falcone, Andrea Lees, Simon S. McDade
Publikováno v:
Cancer Research. 78:5425-5425
Background Prostate cancer (PCa) is now the most commonly diagnosed malignancy in men worldwide. SOC combines radiotherapy with ADT, however recurrence rate remains unacceptably high and many men present with late stage aggressive and metastatic dise
Autor:
Fiammetta Falcone, Gemma M.A. Gregg, Simon S. McDade, Gerard P. Quinn, Longley B. Daniel, Alexander J. McIntyre, Andrea Lees, Phillip D. Dunne, Sessler Tamas, Nyree Crawford, Darragh G. McArt, Mark Lawler
Publikováno v:
Cancer Research. 78:4385-4385
Background The tumor suppressive functions of the p53 transcription factor are inactivated via mutations or suppressed through non-mutational mechanisms in almost all cancer cells. A better understanding of the mechanisms through which p53 differenti