Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gemma M. Dingjan"'
Autor:
Robert W A M Kuijpers, Gemma M. Dingjan, Tom Missotten, Herbert Hooijkaas, P. Martin van Hagen, Kiki van Bilsen, G. Seerp Baarsma, Willem A. Dik, Jan C. van Meurs, Jeroen Bastiaans
Publikováno v:
British Journal of Ophthalmology, 95(6), 864-868. BMJ Publishing Group
Background/aims The neonatal Fc receptor (FcRn) protects immunoglobulin G (IgG) from catabolism, controls its transport between cell layers and extends its serum half-life. In the human, vitreous IgG can be found, but how vitreous IgG is processed or
Publikováno v:
Leukemia, 25(1), 48-56. Nature Publishing Group
The adapter protein Slp65 and Bruton's tyrosine kinase (Btk) are key components of the precursor-B (pre-B) cell receptor (pre-BCR) signaling pathway. Slp65-deficient mice spontaneously develop pre-B-cell leukemia, expressing high levels of the pre-BC
Autor:
Laurens P. Kil, Marten van der Zee, Alex Maas, Gemma M. Dingjan, Sabine Middendorp, Roelof Flierman, Rudi W. Hendriks, Rogier Kersseboom
Publikováno v:
European Journal of Immunology, 40(9), 2643-2654. Wiley-VCH
B-cell receptor (BCR)-mediated signals provide the basis for B-cell differentiation in the BM and subsequently into follicular, marginal zone, or B-1 B-cell subsets. We have previously shown that B-cell-specific expression of the constitutive active
Autor:
Claudia Ribeiro de Almeida, Gemma M. Dingjan, Ingrid M. Bergen, Sanja Krpic, Suzanne van de Nobelen, Helen Heath, Frank Grosveld, Niels Galjart, Rudi W. Hendriks, Frank Sleutels, Jan Piet van Hamburg
Publikováno v:
Journal of Immunology, 182(2), 999-1010. American Association of Immunologists
Differentiation of naive CD4+ cells into Th2 cells is accompanied by chromatin remodeling at the Th2 cytokine locus allowing the expression of the IL-4, IL-5, and IL-13 genes. In this report, we investigated the role in Th2 differentiation of the tra
Autor:
Willem A. Dik, Benjamin Schrijver, P. Martin van Hagen, Dion Paridaens, Willem A. van den Bosch, Herbert Hooijkaas, Leendert van Steensel, Gemma M. Dingjan, Hemmo A. Drexhage, Paul L A van Daele
Publikováno v:
Investigative Ophthalmology & Visual Science, 50(7), 3091-3098. Association for Research in Vision and Ophthalmology Inc.
PURPOSE. Excessive orbital fibroblast proliferation and hyaluronan production are characteristic of Graves' ophthalmopathy (GO) and are driven by local mediators. Imatinib mesylate and AMN107 are tyrosine kinase inhibitors that inhibit fibroblast pro
Autor:
Marjolein J. W. de Bruijn, Jan Piet van Hamburg, H. Berna Beverloo, Hans J. A. Diepstraten, Kam-Wing Ling, Gemma M. Dingjan, Rudi W. Hendriks
Publikováno v:
Molecular immunology, 45(11), 3085-3095. Elsevier Limited
Molecular Immunology, 45(11), 3085-3095. Elsevier Ltd.
Molecular Immunology, 45(11), 3085-3095. Elsevier Ltd.
Gata transcription factors are critical regulators of proliferation and differentiation implicated in various human cancers, but specific genes activated by Gata proteins remain to be identified. We previously reported that enforced expression of Gat
Publikováno v:
Immunity, 27(3), 468-480. Cell Press
SummaryThe pre-B cell receptor (pre-BCR), composed of immunoglobulin μ heavy chain and the surrogate light chain (SLC) proteins λ5 and Vpreb, signals for proliferation and maturation of developing pre-B cells. It has been assumed that pre-B cells s
Autor:
Katarina Dahlenborg, Sabine Middendorp, Gemma M. Dingjan, Alex Maas, Rudolf W. Hendriks, Frank Grosveld
Publikováno v:
Journal of Experimental Medicine, 193(10), 1169-1178. Rockefeller University Press
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase involved in precursor B (pre-B) cell receptor signaling. Here we demonstrate that Btk-deficient mice have an approximately 50% reduction in the frequency of immunoglobulin (Ig) lambda li
Publikováno v:
The Journal of Immunology. 162:6526-6533
Bruton’s tyrosine kinase (Btk) is a nonreceptor protein kinase that is defective in X-linked agammaglobulinemia in humans and in X-linked immunodeficiency in mice. To study the effect of Btk activation in early B cell development in vivo, we have c
Autor:
Christine Kinnon, Rudolf W. Hendriks, Huub F. J. Savelkoul, Frank Grosveld, Gemma M. Dingjan, Alex Maas
Publikováno v:
European Journal of Immunology, 27, 2180-2187. Wiley-VCH
Mutations in the gene for Bruton's tyrosine kinase result in the B cell differentiation defects X-linked agammaglobulinemia in man and X-linked immunodeficiency in mice. Here we describ the generation of two yeast artificial chromesome (YAC)-transgen