Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Gemma L. Kelly"'
Autor:
Yexuan Deng, Sarah T. Diepstraten, Margaret A. Potts, Göknur Giner, Stephanie Trezise, Ashley P. Ng, Gerry Healey, Serena R. Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J. Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S. Alexander, Jane E. Visvader, Stephen L. Nutt, Andreas Strasser, Benjamin Haley, Quan Zhao, Gemma L. Kelly, Marco J. Herold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Modelling of aggressive lymphomas, such as double hit lymphoma, has been challenging. Here the authors engineer a CRISPR activation mouse to enable the generation of these aggressive lymphomas and identify the pro-survival BCL-2 protein A1 as a venet
Externí odkaz:
https://doaj.org/article/a6a1367d102e4deb8dbd0ddb559ac31c
Autor:
John E. La Marca, Robert W. Ely, Sarah T. Diepstraten, Peter Burke, Gemma L. Kelly, Patrick O. Humbert, Helena E. Richardson
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 3 (2023)
Externí odkaz:
https://doaj.org/article/e9522fc36290440fb2985f54b8531064
Autor:
Yexuan Deng, Sarah T. Diepstraten, Margaret A. Potts, Göknur Giner, Stephanie Trezise, Ashley P. Ng, Gerry Healey, Serena R. Kane, Amali Cooray, Kira Behrens, Amy Heidersbach, Andrew J. Kueh, Martin Pal, Stephen Wilcox, Lin Tai, Warren S. Alexander, Jane E. Visvader, Stephen L. Nutt, Andreas Strasser, Benjamin Haley, Quan Zhao, Gemma L. Kelly, Marco J. Herold
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/cc4c296b2b374573b5cc8009f758bbc9
Autor:
Hui San Chin, Mark X. Li, Iris K. L. Tan, Robert L. Ninnis, Boris Reljic, Kristen Scicluna, Laura F. Dagley, Jarrod J. Sandow, Gemma L. Kelly, Andre L. Samson, Stephane Chappaz, Seong L. Khaw, Catherine Chang, Andrew Morokoff, Kerstin Brinkmann, Andrew Webb, Colin Hockings, Cathrine M. Hall, Andrew J. Kueh, Michael T. Ryan, Ruth M. Kluck, Philippe Bouillet, Marco J. Herold, Daniel H. D. Gray, David C. S. Huang, Mark F. van Delft, Grant Dewson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
BAX and BAK are pro-apoptotic proteins whose activity is essential for the action of many anti-cancer drugs and to suppress tumorigenesis. Here, the authors perform a genome-wide CRISPR/Cas9 screen and identify VDAC2 as a promoter of BAX-mediated apo
Externí odkaz:
https://doaj.org/article/7dd8f93e7c6542b48b8f7611205cb9c8
Autor:
Liz J. Valente, Brandon J. Aubrey, Marco J. Herold, Gemma L. Kelly, Lina Happo, Clare L. Scott, Andrea Newbold, Ricky W. Johnstone, David C.S. Huang, Lyubomir T. Vassilev, Andreas Strasser
Publikováno v:
Cell Reports, Vol 14, Iss 8, Pp 1858-1866 (2016)
Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached cl
Externí odkaz:
https://doaj.org/article/52a55445e4b54bfcb568bd86fe2147c2
Autor:
David M. Wong, Lingli Li, Sabine Jurado, Ashleigh King, Rebecca Bamford, Meaghan Wall, Mannu K. Walia, Gemma L. Kelly, Carl R. Walkley, David M. Tarlinton, Andreas Strasser, Jörg Heierhorst
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1488-1499 (2016)
How MYC promotes the development of cancer remains to be fully understood. Here, we report that the Zn2+-finger transcription factor ASCIZ (ATMIN, ZNF822) synergizes with MYC to activate the expression of dynein light chain (DYNLL1, LC8) in the murin
Externí odkaz:
https://doaj.org/article/5452af9f1b96487f9e7a9fc15d95b041
Autor:
Brandon J. Aubrey, Gemma L. Kelly, Andrew J. Kueh, Margs S. Brennan, Liam O’Connor, Liz Milla, Stephen Wilcox, Lin Tai, Andreas Strasser, Marco J. Herold
Publikováno v:
Cell Reports, Vol 10, Iss 8, Pp 1422-1432 (2015)
The CRISPR/Cas9 technology enables the introduction of genomic alterations into almost any organism; however, systems for efficient and inducible gene modification have been lacking, especially for deletion of essential genes. Here, we describe a dru
Externí odkaz:
https://doaj.org/article/8d2dabf89b8c424cbdc8e730ac3f79ed
Autor:
Leah Fitzsimmons, Gemma L. Kelly
Publikováno v:
Viruses, Vol 9, Iss 11, p 339 (2017)
Epstein–Barr virus (EBV) was first discovered in cells from a patient with Burkitt lymphoma (BL), and is now known to be a contributory factor in 1–2% of all cancers, for which there are as yet, no EBV-targeted therapies available. Like other her
Externí odkaz:
https://doaj.org/article/f4a3fdcf202b4c2c9072d6c71d57cdda
Publikováno v:
Precision Cancer Therapies, Volume 1 ‐ Targeting Oncogenic Drivers and Signaling Pathways in Lymphoid Malignancies. :131-150
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6dad7330ba0708301fa26dacde88e67
https://doi.org/10.1002/9781119819950.ch10
https://doi.org/10.1002/9781119819950.ch10
Autor:
Sarah T. Diepstraten, Savannah Young, John E. La Marca, Zilu Wang, Ruth M. Kluck, Andreas Strasser, Gemma L. Kelly
Publikováno v:
Cell Death & Differentiation. 30:1005-1017
BH3-mimetic drugs are an anti-cancer therapy that can induce apoptosis in malignant cells by directly binding and inhibiting pro-survival proteins of the BCL-2 family. The BH3-mimetic drug venetoclax, which targets BCL-2, has been approved for the tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85ea1312259fcc81d8a6fbbe2c9ad788
https://doi.org/10.1038/s41418-023-01117-0
https://doi.org/10.1038/s41418-023-01117-0