Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Gemma L Holliday"'
Exploring the evolution of novel enzyme functions within structurally defined protein superfamilies.
Autor:
Nicholas Furnham, Ian Sillitoe, Gemma L Holliday, Alison L Cuff, Roman A Laskowski, Christine A Orengo, Janet M Thornton
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 3, p e1002403 (2012)
In order to understand the evolution of enzyme reactions and to gain an overview of biological catalysis we have combined sequence and structural data to generate phylogenetic trees in an analysis of 276 structurally defined enzyme superfamilies, and
Externí odkaz:
https://doaj.org/article/3f40aaa07cb648a8bc60cdf2ba6ec48b
Autor:
Nick E J Etherington, Ashley J Evans, Mark P Laing, Brad Rollings, Michael J Sweeton, Alex J Whitehorn, C Southan, Gemma L Holliday, Rafael C Jimenez, Ian W Dunlop
SummaryBio-Aurac is an open-source web browser plugin designed to support the research community in drug discovery and life sciences. The tool has been designed to help researchers, scientists, and curators to better explore, navigate and understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fc4aeb2421c0a32c6e48336a71157a2
https://doi.org/10.1101/2022.09.23.508995
https://doi.org/10.1101/2022.09.23.508995
Autor:
Janet M. Thornton, António J. M. Ribeiro, Jonathan D. Tyzack, Neera Borkakoti, Gemma L. Holliday
Publikováno v:
Journal of Biological Chemistry. 295:314-324
The catalytic residues of an enzyme comprise the amino acids located in the active center responsible for accelerating the enzyme-catalyzed reaction. These residues lower the activation energy of reactions by performing several catalytic functions. D
Autor:
Patricia C. Babbitt, Jake LeVieux, Eyal Akiva, Yan Jessie Zhang, Rebecca Davidson, Collin R. Pullara, Christian P. Whitman, Bert-Jan Baas, Benjamin J. Polacco, Gemma L. Holliday
Publikováno v:
The Journal of Biological Chemistry
The tautomerase superfamily (TSF) consists of more than 11,000 nonredundant sequences present throughout the biosphere. Characterized members have attracted much attention because of the unusual and key catalytic role of an N-terminal proline. These
Autor:
Patricia C. Babbitt, Gemma L. Holliday, Shoshana D. Brown, David Mischel, Benjamin J. Polacco
Publikováno v:
Database: The Journal of Biological Databases and Curation
Determining the molecular function of enzymes discovered by genome sequencing represents a primary foundation for understanding many aspects of biology. Historically, classification of enzyme reactions has used the enzyme nomenclature system develope
Atlas of the Radical SAM Superfamily: Divergent Evolution of Function Using a 'Plug and Play' Domain
Autor:
Gemma L. Holliday, Elaine C. Meng, Patricia C. Babbitt, Shoshana D. Brown, Ursula Pieper, Sara Calhoun, Eyal Akiva, Andrej Sali, Squire J. Booker
Publikováno v:
Methods in enzymology. 606
The radical SAM superfamily contains over 100,000 homologous enzymes that catalyze a remarkably broad range of reactions required for life, including metabolism, nucleic acid modification, and biogenesis of cofactors. While the highly conserved SAM-b
Publikováno v:
Proceedings of MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition.
M-CSA (Mechanism And Catalytic Site Atlas) is a database of enzyme mechanisms that can be accessed at www.ebi.ac.uk/thornton-srv/m-csa. Our objectives with M-CSA are to provide an open data resource for the community to browse known enzyme reaction m
Autor:
Nicholas Furnham, Gemma L. Holliday, Katherine Ferris, António J. M. Ribeiro, Janet M. Thornton, Jonathan D. Tyzack
Publikováno v:
Nucleic Acids Research
M-CSA (Mechanism and Catalytic Site Atlas) is a database of enzyme active sites and reaction mechanisms that can be accessed at www.ebi.ac.uk/thornton-srv/m-csa. Our objectives with M-CSA are to provide an open data resource for the community to brow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0dd2710a29d7edf2760ab1090ea186
Autor:
Shoshana D. Brown, Scott C.-H. Pegg, Elaine C. Meng, Conrad C. Huang, Patricia C. Babbitt, Eyal Akiva, Michael A. Hicks, John H. Morris, David Mischel, Gemma L. Holliday, Thomas E. Ferrin
Publikováno v:
Database: The Journal of Biological Databases and Curation
Author(s): Holliday, Gemma L; Brown, Shoshana D; Akiva, Eyal; Mischel, David; Hicks, Michael A; Morris, John H; Huang, Conrad C; Meng, Elaine C; Pegg, Scott C-H; Ferrin, Thomas E; Babbitt, Patricia C | Abstract: With ever-increasing amounts of sequen
Autor:
Nicholas Furnham, Sergio Martínez Cuesta, Gemma L. Holliday, Syed Asad Rahman, Janet M. Thornton
Publikováno v:
Nature methods
EC-BLAST is an algorithm for quantitative similarity searches between enzyme reactions at three levels a) bond change, b) reaction centre and c) reaction structure similarity. It exploits the knowledge of bond changes and reaction patterns for all kn