Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Gemma L, Nixon"'
Autor:
Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chem
Externí odkaz:
https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73
Autor:
Laura N. Jeffreys, Alison Ardrey, Taghreed A. Hafiz, Lauri-Anne Dyer, Ashley J. Warman, Nada Mosallam, Gemma L. Nixon, Nicholas E. Fisher, W. David Hong, Suet C. Leung, Ghaith Aljayyoussi, Jaclyn Bibby, Deepak V. Almeida, Paul J. Converse, Nader Fotouhi, Neil G. Berry, Eric L. Nuermberger, Anna M. Upton, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
ACS Infectious Diseases. 9:221-238
Autor:
Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is eff
Externí odkaz:
https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f
Autor:
Peter J. H. Webborn, Stefan Kavanagh, Andrew Cassidy, Paul M. O'Neill, Rachel H. Clare, Mark J. Taylor, Mark C. Wenlock, Neil G. Berry, W. David Hong, Darren A. N. Cook, Gemma L. Nixon, Stephen A. Ward, Paul McGillan, Suet C. Leung, Kelly L. Johnston, Louise Ford
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Autor:
Donatella Taramelli, Nicoletta Basilico, Silvia Parapini, Christopher M Woodley, Keiko Onuma, Suet C. Leung, Paul M. O'Neill, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward, Takashi Hasebe, Weiqian David Hong
Publikováno v:
ACS Med Chem Lett
[Image: see text] Synthetic endoperoxide antimalarials, such as 1,2,4-trioxolanes and 1,2,4,5-tetraoxanes, are promising successors for current front-line antimalarials, semisynthetic artemisinin derivatives. However, limited solubility of second-gen
Autor:
Paul, McGillan, Neil G, Berry, Gemma L, Nixon, Suet C, Leung, Peter J H, Webborn, Mark C, Wenlock, Stefan, Kavanagh, Andrew, Cassidy, Rachel H, Clare, Darren A, Cook, Kelly L, Johnston, Louise, Ford, Stephen A, Ward, Mark J, Taylor, W David, Hong, Paul M, O'Neill
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Autor:
Shaun H. Pennington, Paul M. O'Neill, Suet C. Leung, Sophie L Pate, Ghaith Aljayyoussi, Andrew Owen, Gemma L. Nixon, Rajith K. R. Rajoli, Stephen A. Ward, Weiqian David Hong, Andrew V. Stachulski, Giancarlo A. Biagini, Joshua Taujanskas
Publikováno v:
ACS Infectious Diseases
The rapidly growing COVID-19 pandemic is the most serious global health crisis since the "Spanish flu" of 1918. There is currently no proven effective drug treatment or prophylaxis for this coronavirus infection. While developing safe and effective v
Autor:
Richard S. Priestley, Giancarlo A. Biagini, Paul M. O'Neill, Kangsa Amporndanai, Jill Davies, W. David Hong, Gemma L. Nixon, Svetlana V. Antonyuk, Stephen A. Ward, Suet C. Leung, S. Samar Hasnain, Neil G. Berry
Publikováno v:
ACS Medicinal Chemistry Letters
[Image: see text] A series of 2-pyrazolyl quinolones has been designed and synthesized in 5–7 steps to optimize for both in vitro antimalarial potency and various in vitro drug metabolism and pharmacokinetics (DMPK) features. The most potent compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1e1ed03122835c304452b49c545bff
https://doi.org/10.1021/acsmedchemlett.8b00371
https://doi.org/10.1021/acsmedchemlett.8b00371
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis
Autor:
Paul M. O'Neill, Edward W. Tate, W. David Hong, Adam P. Roberts, Marc P. Hübner, Peter J. H. Webborn, Mark J. Taylor, Alexandra Ehrens, Stefan J. Frohberger, Dominique Struever, John Archer, Farid Benayoud, Joseph D. Turner, Rachel H. Clare, Achim Hoerauf, Stefan Kavanagh, Fabian Gusovsky, Andrew Steven, Neil G. Berry, Kelly L. Johnston, Ghaith Aljayyoussi, Andrew Cassidy, Remigiusz A. Serwa, Suet C. Leung, Janet Hemingway, Alasdair T. M. Hubbard, Gemma L. Nixon, Amy Siu, Stephen A. Ward, Emma A Murphy, Louise Ford, Li Qie, Motohiro Shiotani, Darren A. N. Cook
Publikováno v:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d971c5d526af7ac9de5fb24d20f2893d
Autor:
W David, Hong, Farid, Benayoud, Gemma L, Nixon, Louise, Ford, Kelly L, Johnston, Rachel H, Clare, Andrew, Cassidy, Darren A N, Cook, Amy, Siu, Motohiro, Shiotani, Peter J H, Webborn, Stefan, Kavanagh, Ghaith, Aljayyoussi, Emma, Murphy, Andrew, Steven, John, Archer, Dominique, Struever, Stefan J, Frohberger, Alexandra, Ehrens, Marc P, Hübner, Achim, Hoerauf, Adam P, Roberts, Alasdair T M, Hubbard, Edward W, Tate, Remigiusz A, Serwa, Suet C, Leung, Li, Qie, Neil G, Berry, Fabian, Gusovsky, Janet, Hemingway, Joseph D, Turner, Mark J, Taylor, Stephen A, Ward, Paul M, O'Neill
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Onchocerciasis (river blindness) and lymphatic filariasis (elephantiasis) are neglected tropical diseases that cause severe disability and affect more than 157 million people globally. Current control efforts are hindered by the lack of