Výsledky vyhledávání - "Gemma K. Greenwood"

Akademický článek

The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo.

Autor: Jessica A Wray, Mary C Sugden, Darryl C Zeldin, Gemma K Greenwood, Salma Samsuddin, Laura Miller-Degraff, J Alyce Bradbury, Mark J Holness, Timothy D Warner, David Bishop-Bailey

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7421 (2009)

Peroxisome proliferator-activated receptors (PPARs) are a family of three (PPARalpha, -beta/delta, and -gamma) nuclear receptors. In particular, PPARalpha is involved in regulation of fatty acid metabolism, cell growth and inflammation. PPARalpha med

Externí odkaz: https://doaj.org/article/8417b0abe532426a9c9bb03ae953e418

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PPARα activation and increased dietary lipid oppose thyroid hormone signaling and rescue impaired glucose-stimulated insulin secretion in hyperthyroidism

Autor: Gemma K. Greenwood, Mary C. Sugden, Mark J. Holness, Nicholas D. Smith

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 295:E1380-E1389

The aim of the study was to investigate the impact of hyperthyroidism on the characteristics of the islet insulin secretory response to glucose, particularly the consequences of competition between thyroid hormone and peroxisome proliferator-activate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b16bac7663c015d1c87ba3701dbe2b4
https://doi.org/10.1152/ajpendo.90700.2008

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Acute ω-3 Fatty Acid Enrichment Selectively Reverses High-Saturated Fat Feeding-Induced Insulin Hypersecretion But Does Not Improve Peripheral Insulin Resistance

Autor: M J Holness, Nicholas D. Smith, Mary C. Sugden, Gemma K. Greenwood

Publikováno v: Diabetes. 53:S166-S171

In rats fed a high-saturated fat diet, replacement of a small percentage of total fatty acids with long-chain ω-3 fatty acids from fish oil for the duration of high-fat feeding prevents the development of insulin resistance. We investigated the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5389fcee375458f2defea668e757d80
https://doi.org/10.2337/diabetes.53.2007.s166

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Peroxisome Proliferator-Activated Receptor-α Activation during Pregnancy Attenuates Glucose-Stimulated Insulin Hypersecretion in Vivo by Increasing Insulin Sensitivity, without Impairing Pregnancy-Induced Increases in β-Cell Glucose Sensing and Responsiveness

Autor: Gemma K. Greenwood, Nicholas D. Smith, Mark J. Holness, Mary C. Sugden

Publikováno v: Endocrinology. 144:146-153

We investigated the effects of acute (24-h) peroxisome proliferator-activated receptor (PPAR)alpha activation by WY14,643 (pirinixic acid) treatment on glucose-stimulated insulin secretion (GSIS) during pregnancy, in the rat, in relation to insulin s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e444b2d89bb2e76750402ae508b635c6
https://doi.org/10.1210/en.2002-220811

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Improved 2,4-diarylthiazole-based antiprion agents: switching the sense of the amide group at C5 leads to an increase in potency

Autor: Nathan B. P. Adams, Jennifer C. Louth, Fiona J. Sorrell, Gemma K. Greenwood, Mark J. Thompson, Beining Chen, Sandra G. Knight

Publikováno v: ChemMedChem. 5(9)

Amide derivatives of 2,4-diarylthiazole-5-carboxylic acids were synthesised and tested for efficacy in a cell line model of prion disease. A number of compounds demonstrating antiprion activity were thereby identified from the screening libraries, sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5d62b6afc55c6a86b6dd6d002185be
https://pubmed.ncbi.nlm.nih.gov/20635376

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Development of a differential scanning fluorimetry based high throughput screening assay for the discovery of affinity binders against an anthrax protein

Autor: Kristian Birchall, Fiona J. Sorrell, Gemma K. Greenwood, Beining Chen

Publikováno v: Journal of pharmaceutical and biomedical analysis. 52(5)

The anthrax protein protective antigen (PA) is responsible for cell-surface recognition and aids the delivery of the toxic anthrax enzymes into host cells. By targeting PA and preventing it from binding to host cells, it is hoped that the delivery of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52ccf46117d0100503e2f2429b8335e
https://pubmed.ncbi.nlm.nih.gov/20376913

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The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo

Autor: Salma Samsuddin, Mark J. Holness, Laura Miller-Degraff, Jessica A. Wray, Darryl C. Zeldin, Mary C. Sugden, Gemma K. Greenwood, J. Alyce Bradbury, David Bishop-Bailey, Timothy D. Warner

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7421 (2009)
PLoS ONE

Background: Peroxisome proliferator-activated receptors (PPARs) are a family of three (PPARa ,- b/d, and -c) nuclear receptors. In particular, PPARa is involved in regulation of fatty acid metabolism, cell growth and inflammation. PPARa mediates the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030deb462e10dacc6b7e23281f2b44c0
http://europepmc.org/articles/PMC2756622?pdf=render

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PPARalpha activation reverses adverse effects induced by high-saturated-fat feeding on pancreatic beta-cell function in late pregnancy

Autor: Nicholas D. Smith, Mark J. Holness, Mary C. Sugden, Gemma K. Greenwood

Publikováno v: American journal of physiology. Endocrinology and metabolism. 292(4)

We examined whether the additional demand for insulin secretion imposed by dietary saturated fat-induced insulin resistance during pregnancy is accommodated at late pregnancy, already characterized by insulin resistance. We also assessed whether effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2248f5486fcf8b9719f10deed9869c49
https://pubmed.ncbi.nlm.nih.gov/17164438

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