Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gemma Higgs"'
Autor:
Sean E. Egan, Paul W. Frankland, Alexander Marsolais, Derya Sargin, Leigh C.P. Botly, Gemma Higgs, Sheena A. Josselyn
Publikováno v:
Neurobiology of Learning and Memory. 105:20-30
It is well-known that Notch signaling plays a critical role in brain development and growing evidence implicates this signaling pathway in adult synaptic plasticity and memory formation. The Notch1 receptor is activated by two subclasses of ligands,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baaa58bec32dea7cd4dda3e34f3f0d99
https://doi.org/10.1016/j.nlm.2013.07.001
https://doi.org/10.1016/j.nlm.2013.07.001
Autor:
Simon Philip Brooks, Peter Giles, Gemma Higgs, Stephen B. Dunnett, Lesley Jones, Linda Anne Elliston
Publikováno v:
Brain Research Bulletin. 88:199-209
Substantial transcriptional changes are seen in Huntington's disease (HD) brain and parallel early changes in gene expression are observed in mouse models of HD. Analysis of behaviour in such models also shows substantial deficits in motor, learning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8220fb09f16316b70c7871c7ae030ab
https://doi.org/10.1016/j.brainresbull.2011.10.001
https://doi.org/10.1016/j.brainresbull.2011.10.001
Publikováno v:
Brain Research Bulletin. 88:148-155
Huntington's disease is caused by a single mutation resulting in an expanded polyglutamine sequence which causes the production of a mutant variant of the protein huntingtin, which is ultimately responsible for the motor, cognitive and emotional symp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fbcbdca623a2414e00f420684fab7e
https://doi.org/10.1016/j.brainresbull.2010.05.003
https://doi.org/10.1016/j.brainresbull.2010.05.003
Autor:
Andreas Heuer, L. A. Jones, Zubeyde Bayram-Weston, SB Dunnett, Gemma Higgs, Narinder Janghra, Simon Philip Brooks
Publikováno v:
Clinical Genetics. 76:76-84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c03117415aa9587d34a82fabecd0230f
https://doi.org/10.1111/j.1399-0004.2009.01224.x
https://doi.org/10.1111/j.1399-0004.2009.01224.x
Autor:
Peter Holmans, Stephen B. Dunnett, Gemma Higgs, Zubeyde Bayram-Weston, Timothy Stone, Lesley Jones, Narinder Janghra, Linda Anne Elliston, Peter Giles, Simon Philip Brooks
Publikováno v:
BMC Genomics
Background The YAC128 model of Huntington’s disease (HD) shows substantial deficits in motor, learning and memory tasks and alterations in its transcriptional profile. We examined the changes in the transcriptional profile in the YAC128 mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4245f5e37f6ab8db0785c22cf171bf
https://cronfa.swan.ac.uk/Record/cronfa46021/Download/46021__25601__745ac0ab0b534451b21fc529f7c1d7a9.pdf
https://cronfa.swan.ac.uk/Record/cronfa46021/Download/46021__25601__745ac0ab0b534451b21fc529f7c1d7a9.pdf
Autor:
Sean E. Egan, Leigh C.P. Botly, Alexander Marsolais, Gemma Higgs, Sheena A. Josselyn, Derya Sargin, Paul W. Frankland
Publikováno v:
Neurobiology of learning and memory. 103
It is well-known that Notch signaling plays a critical role in brain development and growing evidence implicates this signaling pathway in adult synaptic plasticity and memory formation. The Notch1 receptor is activated by two subclasses of ligands,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa647f19b3e6b098d4fe7483273d2ee
https://pubmed.ncbi.nlm.nih.gov/23850596
https://pubmed.ncbi.nlm.nih.gov/23850596
Autor:
Stephen B. Dunnett, Lesley Jones, Zubeyde Bayram-Weston, Simon Philip Brooks, Gemma Higgs, Narinder Janghra, Andreas Heuer
Publikováno v:
Brain research bulletin. 88(2-3)
People with HD have a demonstrated early extra-dimensional set-shifting deficit. In the present study, we use a novel water T-maze set-shifting procedure and demonstrate its validity as a set-shifting task in a mouse model of Huntington's disease. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c7cb32ae8dfd417f84c0bf832cd1b2
https://pubmed.ncbi.nlm.nih.gov/21624441
https://pubmed.ncbi.nlm.nih.gov/21624441
Longitudinal analysis of the behavioural phenotype in Hdh(CAG)150 Huntington's disease knock-in mice
Publikováno v:
Brain research bulletin. 88(2-3)
In people with Huntington's disease, an expanded CAG repeat sequence on the HTT gene confers a toxic gain function resulting in a progressive and fatal neurodegeneration. The Hdh((CAG)Q150) Huntington's disease mouse line is a knock-in model of the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54742c369a490e37aaa173ad233705f
https://pubmed.ncbi.nlm.nih.gov/20457230
https://pubmed.ncbi.nlm.nih.gov/20457230