Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gemma C. Parsons"'
Autor:
Tram T. Tran, Rachel Dixon, Duncan Hay, James Hitchin, Gemma C. Parsons, David C. Pryde, Gerwyn Bish, Michael Paradowski, Fiona M. Adam, Nicholas Smith, Peter Jones, M. Jonathan Fray, Katie J. W. Proctor, Frederick Calo
Publikováno v:
Tetrahedron Letters. 52:5728-5732
A flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, inclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c13cab43378c9676f70600e4494b897b
https://doi.org/10.1016/j.tetlet.2011.08.119
https://doi.org/10.1016/j.tetlet.2011.08.119
Autor:
Craig J. Knight, Katie J. W. Proctor, Nicholas Smith, David C. Pryde, Christopher L. Carr, Peter Jones, Gerwyn Bish, Nieves Castro, Hodgson Paul Blaise, Filippo Rota, Frederick Calo, Duncan Hay, Mya C. Smith, James Hitchin, Tram T. Tran, Rachel Dixon, Michael Paradowski, Fiona M. Adam, Gemma C. Parsons
Publikováno v:
Organic Process Research & Development. 15:788-796
The development and implementation of a scalable process for the manufacture of the Toll-like receptor (TLR7) agonist PF-4171455 (1) is described. Initial routes used to synthesise 1 in milligram quantities were unsuitable for large-scale synthesis t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25b51da65de0e0a90344001848dd6c54
https://doi.org/10.1021/op200021a
https://doi.org/10.1021/op200021a
Autor:
Carl Laxton, Nicholas Smith, Martin Howard, Gerwyn Bish, Duncan Hay, Mya C. Smith, James Hitchin, Tram T. Tran, David C. Pryde, Hannah M. Jones, Peter Jones, Nigel Horscroft, Gemma C. Parsons, Rachel Dixon, Frederick Calo, Katie J. W. Proctor, Fox David Nathan Abraham, Jonathan Duckworth, Neil Benson, Amy Thomas, Iain Gardner, Tanya Parkinson, Fiona M. Adam, Guiseppe Ciaramella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2389-2393
The synthesis and structure-activity relationships of a series of novel interferon inducers are described. Pharmacokinetic studies and efficacy assessment of a series of 8-oxo-3-deazapurine analogues led to the identification of compound 33, a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3f64c50e8a92b29c2e40cbf07d158d
https://doi.org/10.1016/j.bmcl.2011.02.092
https://doi.org/10.1016/j.bmcl.2011.02.092
Autor:
Gerwyn Bish, Anthony Harrison, Michael Paradowski, Nicholas Smith, Gemma C. Parsons, Tanya Parkinson, Donald Stuart Middleton, Carl Laxton, Peter Jones, Fox David Nathan Abraham, Tram T. Tran, Fiona M. Adam, Hannah M. Jones, Giuseppe Ciaramella, Frederick Calo, Jonathan Duckworth, Katie J. W. Proctor, David C. Pryde, Rob Webster, Duncan Hay, Mya C. Smith, Neil Benson, Nigel Horscroft
Publikováno v:
Med. Chem. Commun.. 2:185-189
A series of heterocycle analogues of an adenine template were explored for TLR7 agonist potency and pharmacokinetics. One compound was identified with an excellent pharmacokinetic, in vitro potency and in vivo interferon induction profile in a mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20345103a70c1c2f6f7d0a88c9962d6f
https://doi.org/10.1039/c0md00197j
https://doi.org/10.1039/c0md00197j
Autor:
Gemma C. Parsons, Peter T. Stephenson, Michelle Y. Platts, Barber Christopher Gordon, Blanda Luzia Christa Stammen, David C. Pryde, David Ellis, David W. Gordon, Helen J. Mason, Rachel L. Eastwood, Catherine Burt, Donald Stuart Middleton, David Bachelor, Martin Corless, Keith Statham, Anthony Wood, Wolfgang Klute, Kerry A. Paradowski, David C. Blakemore, David R. Fenwick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1084-1088
The synthesis of a range of novel amine-containing structures and their primary potency as inhibitors of HIV-1 fusion via blocking of the CCR5 receptor is described. The development of the medicinal chemistry strategy and SAR's which led to the ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619f831846652fe35ab392fac3f0b7c7
https://doi.org/10.1016/j.bmcl.2009.01.012
https://doi.org/10.1016/j.bmcl.2009.01.012
Autor:
Carl Laxton, David C. Pryde, Fiona M. Adam, Gerwyn Bish, Duncan Hay, Mya C. Smith, James Hitchin, Peter Jones, Tanya Parkinson, Nigel Horscroft, Tram T. Tran, Jonathan Duckworth, Rachel Dixon, Gemma C. Parsons, Guiseppe Ciaramella, Fox David Nathan Abraham, Katie J. W. Proctor, Frederick Calo, Amy Thomas, Nicholas Smith, Martin Howard
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
The discovery of a series of highly potent and novel TLR7 agonist interferon inducers is described. Structure-activity relationships are presented, along with pharmacokinetic studies of a lead molecule from this series of N9-pyridylmethyl-8-oxo-3-dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::934d1fcd9e52845e8234105509bed653
https://pubmed.ncbi.nlm.nih.gov/21885277
https://pubmed.ncbi.nlm.nih.gov/21885277