Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Gemma C Sharp"'
Autor:
Ziyi Xiong, Gabriela Dankova, Laurence J Howe, Myoung Keun Lee, Pirro G Hysi, Markus A de Jong, Gu Zhu, Kaustubh Adhikari, Dan Li, Yi Li, Bo Pan, Eleanor Feingold, Mary L Marazita, John R Shaffer, Kerrie McAloney, Shu-Hua Xu, Li Jin, Sijia Wang, Femke MS de Vrij, Bas Lendemeijer, Stephen Richmond, Alexei Zhurov, Sarah Lewis, Gemma C Sharp, Lavinia Paternoster, Holly Thompson, Rolando Gonzalez-Jose, Maria Catira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Gabriel Bedoya, Francisco Rothhammer, André G Uitterlinden, M Arfan Ikram, Eppo Wolvius, Steven A Kushner, Tamar EC Nijsten, Robert-Jan TS Palstra, Stefan Boehringer, Sarah E Medland, Kun Tang, Andres Ruiz-Linares, Nicholas G Martin, Timothy D Spector, Evie Stergiakouli, Seth M Weinberg, Fan Liu, Manfred Kayser, On behalf of the International Visible Trait Genetics (VisiGen) Consortium
Publikováno v:
eLife, Vol 8 (2019)
The human face represents a combined set of highly heritable phenotypes, but knowledge on its genetic architecture remains limited, despite the relevance for various fields. A series of genome-wide association studies on 78 facial shape phenotypes qu
Externí odkaz:
https://doaj.org/article/cb141e48e70148ee8bc2e91adf5b6c6e
Autor:
Laurence J Howe, Myoung Keun Lee, Gemma C Sharp, George Davey Smith, Beate St Pourcain, John R Shaffer, Kerstin U Ludwig, Elisabeth Mangold, Mary L Marazita, Eleanor Feingold, Alexei Zhurov, Evie Stergiakouli, Jonathan Sandy, Stephen Richmond, Seth M Weinberg, Gibran Hemani, Sarah J Lewis
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007501 (2018)
There is increasing evidence that genetic risk variants for non-syndromic cleft lip/palate (nsCL/P) are also associated with normal-range variation in facial morphology. However, previous analyses are mostly limited to candidate SNPs and findings hav
Externí odkaz:
https://doaj.org/article/fce4f3a95f2a43b4beeacd55bb4e7ff5
Autor:
Gemma C Sharp, James L Hutchinson, Nanette Hibbert, Tom C Freeman, Philippa T K Saunders, Jane E Norman
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155413 (2016)
An incomplete understanding of the molecular mechanisms that initiate normal human labour at term seriously hampers the development of effective ways to predict, prevent and treat disorders such as preterm labour. Appropriate analysis of large microa
Externí odkaz:
https://doaj.org/article/c4cdcd2aadff45d1b931fb9772ac51e8
Autor:
Shaobo Li, Natalia Spitz, Akram Ghantous, Sarina Abrishamcar, Brigitte Reimann, Irene Marques, Matt J. Silver, Sofía Aguilar-Lacasaña, Negusse Kitaba, Faisal I. Rezwan, Stefan Röder, Lea Sirignano, Johanna Tuhkanen, Giulia Mancano, Gemma C. Sharp, Catherine Metayer, Libby Morimoto, Dan J. Stein, Heather J. Zar, Rossella Alfano, Tim Nawrot, Congrong Wang, Eero Kajantie, Elina Keikkala, Sanna Mustaniemi, Justiina Ronkainen, Sylvain Sebert, Wnurinham Silva, Marja Vääräsmäki, Vincent W. V. Jaddoe, Robin M. Bernstein, Andrew M. Prentice, Marta Cosin-Tomas, Terence Dwyer, Siri Eldevik Håberg, Zdenko Herceg, Maria C. Magnus, Monica Cheng Munthe-Kaas, Christian M. Page, Maja Völker, Maria Gilles, Tabea Send, Stephanie Witt, Lea Zillich, Luigi Gagliardi, Lorenzo Richiardi, Darina Czamara, Katri Räikkönen, Lida Chatzi, Marina Vafeiadi, S. Hasan Arshad, Susan Ewart, Michelle Plusquin, Janine F. Felix, Sophie E. Moore, Martine Vrijheid, John W. Holloway, Wilfried Karmaus, Gunda Herberth, Ana Zenclussen, Fabian Streit, Jari Lahti, Anke Hüls, Thanh T. Hoang, Stephanie J. London, Joseph L. Wiemels
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterat
Externí odkaz:
https://doaj.org/article/a758b4bce3ff4982b903b79fec75b010
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e70180 (2013)
Preterm birth is the single biggest cause of significant neonatal morbidity and mortality, and the incidence is rising. Development of new therapies to treat and prevent preterm labour is seriously hampered by incomplete understanding of the molecula
Externí odkaz:
https://doaj.org/article/98b90eb354b74b299c212979dbb3a3df
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background Few studies have investigated associations between adiposity and reproductive factors using causal methods, both of which have a number of consequences on women’s health. Here we assess whether adiposity at different points in t
Externí odkaz:
https://doaj.org/article/cf44f428fa4c45da8f007931b0805836
Autor:
Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Röder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Räikkönen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Håberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Régine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sørensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melén, Gemma C. Sharp, Matt J. Silver, Faisal I. Rezwan, John W. Holloway
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-23 (2023)
Abstract Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms under
Externí odkaz:
https://doaj.org/article/d655547609c94f51b01a2521002c970a
Autor:
Giulietta S. Monasso, Thanh T. Hoang, Giulia Mancano, Sílvia Fernández-Barrés, John Dou, Vincent W.V. Jaddoe, Christian M. Page, Laura Johnson, Mariona Bustamante, Kelly M. Bakulski, Siri E. Håberg, Per M. Ueland, Thomas Battram, Simon K. Merid, Erik Melén, Doretta Caramaschi, Leanne K. Küpers, Jordi Sunyer, Wenche Nystad, Sandra G. Heil, Rebecca J. Schmidt, Martine Vrijheid, Gemma C. Sharp, Stephanie J. London, Janine F. Felix
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we meta-analysed epigenome-wide
Externí odkaz:
https://doaj.org/article/e080ef2c12ef4dcea3bef66544558f52
Autor:
Laura D. Howe, Deborah A. Lawlor, Gemma Sawyer, Gemma C. Sharp, Gemma Clayton, Abigail Fraser
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Problematic menstrual cycle features, including irregular periods, severe pain, heavy bleeding, absence of periods, frequent or infrequent cycles, and premenstrual symptoms, are experienced by high proportions of females and can have substantial impa
Externí odkaz:
https://doaj.org/article/6e029c339e11428c8acee194f3051305
Autor:
Laura D. Howe, Deborah A. Lawlor, Gemma Sawyer, Gemma C. Sharp, Gemma Clayton, Abigail Fraser
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Problematic menstrual cycle features, including irregular periods, severe pain, heavy bleeding, absence of periods, frequent or infrequent cycles, and premenstrual symptoms, are experienced by high proportions of females and can have substantial impa
Externí odkaz:
https://doaj.org/article/84693e031a26486e8eede7bafa157a91