Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Gemma C Atkinson"'
Autor:
Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Susanne Huch, Marje Kasari, Hiraku Takada, Lilit Nersisyan, Arnfinn Sundsfjord, Kristin Hegstad, Gemma C. Atkinson, Vicent Pelechano, Daniel N. Wilson, Vasili Hauryliuk
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
PoxtA confers resistance to ribosome-targeting oxazolidinone (linezolid) and chloramphenicol antibiotics. Here, Crowe-McAuliffe et al. provide structural insights into how binding of PoxtA to the ribosome indirectly promotes drug dissociation.
Externí odkaz:
https://doaj.org/article/05dd3c38dd694b5fb2e00d979a07f8f8
Autor:
Caillan Crowe-McAuliffe, Victoriia Murina, Kathryn Jane Turnbull, Marje Kasari, Merianne Mohamad, Christine Polte, Hiraku Takada, Karolis Vaitkevicius, Jörgen Johansson, Zoya Ignatova, Gemma C. Atkinson, Alex J. O’Neill, Vasili Hauryliuk, Daniel N. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mitochondrial ribosomes (mitoribosomes) are characterized by a distinct architecture and thus biogenesis pathway. Here, cryo-EM structures of mitoribosome large subunit assembly intermediates elucidate final steps of 16 S rRNA folding, methylation an
Externí odkaz:
https://doaj.org/article/5839d6ab4dd34e3b9dd6b83dd05b0b33
Autor:
Nozomu Obana, Hiraku Takada, Caillan Crowe-McAuliffe, Mizuki Iwamoto, Artyom A Egorov, Kelvin J Y Wu, Shinobu Chiba, Victoriia Murina, Helge Paternoga, Ben I C Tresco, Nobuhiko Nomura, Andrew G Myers, Gemma C Atkinson, Daniel N Wilson, Vasili Hauryliuk
Publikováno v:
Nucleic Acids Research. 51:4536-4554
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The diversity of chromosomally-encoded ARE-ABCFs is far from being fully exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d26f7fbc7cdcb357bec011d2f729f9
https://doi.org/10.1093/nar/gkad193
https://doi.org/10.1093/nar/gkad193
Autor:
Hiraku Takada, Mohammad Roghanian, Victoriia Murina, Ievgen Dzhygyr, Rikinori Murayama, Genki Akanuma, Gemma C. Atkinson, Abel Garcia-Pino, Vasili Hauryliuk
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be
Externí odkaz:
https://doaj.org/article/cfe3282d2ac845f788cfcf5c61081e5c
Autor:
Artyom A Egorov, Gemma C Atkinson
Publikováno v:
Bioinformatics. 39
Summary Upstream open reading frames (uORFs, often encoding so-called leader peptides) can regulate translation and transcription of downstream main ORFs (mORFs) in prokaryotes and eukaryotes. However, annotation of novel functional uORFs is challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e125f5d5fced18744dc9a9dfda1efc33
https://doi.org/10.1093/bioinformatics/btad323
https://doi.org/10.1093/bioinformatics/btad323
Autor:
Andres Ainelo, Julien Caballero-Montes, Ondřej Bulvas, Karin Ernits, Kyo Coppieters ‘t Wallant, Hiraku Takada, Sophie Z. Craig, Gabriel Mazzucchelli, Safia Zedek, Iva Pichová, Gemma C. Atkinson, Ariel Talavera, Chloe Martens, Vasili Hauryliuk, Abel Garcia-Pino
Publikováno v:
Science Advances. 9
Rel stringent factors are bifunctional ribosome-associated enzymes that catalyze both synthesis and hydrolysis of the alarmones (p)ppGpp. Besides the allosteric control by starved ribosomes and (p)ppGpp, Rel is regulated by various protein factors de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9c9e1f1c16953b033af7526ae16ee0
https://doi.org/10.1126/sciadv.ade4077
https://doi.org/10.1126/sciadv.ade4077
Autor:
Nozomu Obana, Hiraku Takada, Caillan Crowe-McAuliffe, Mizuki Iwamoto, Artyom A. Egorov, Kelvin J.Y. Wu, Victoriia Murina, Helge Paternoga, Ben I.C. Tresco, Nobuhiko Nomura, Andrew G. Myers, Gemma C. Atkinson, Daniel N. Wilson, Vasili Hauryliuk
Genome-encoded antibiotic resistance (ARE) ATP-binding cassette (ABC) proteins of the F subfamily (ARE-ABCFs) mediate intrinsic resistance in diverse Gram-positive bacteria. The diversity of chromosomally-encoded ARE-ABCFs is far from being fully exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cc36fda8320347a4d762cc19615334
https://doi.org/10.1101/2022.12.05.519065
https://doi.org/10.1101/2022.12.05.519065
Autor:
Agata L. Starosta, Jürgen Lassak, Lauri Peil, Gemma C. Atkinson, Christopher J. Woolstenhulme, Kai Virumäe, Allen Buskirk, Tanel Tenson, Jaanus Remme, Kirsten Jung, Daniel N. Wilson
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 476-483 (2014)
Bacterial ribosomes stall on polyproline stretches and require the elongation factor P (EF-P) to relieve the arrest. Yet it remains unclear why evolution has favored the development of EF-P rather than selecting against the occurrence of polyproline
Externí odkaz:
https://doaj.org/article/23c5b8d5e45d445fb225503be0fc7649
Autor:
Maxim S. Svetlov, Gemma C. Atkinson, Alexander S. Mankin, Elena V. Aleksandrova, Yury S. Polikanov, Egor A Syroegin, Steven T. Gregory
Publikováno v:
Nature chemical biology
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically relevant mechanism of resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8178edc8a442b3d4479a3bf5afc75ea2
https://doi.org/10.1038/s41589-020-00715-0
https://doi.org/10.1038/s41589-020-00715-0
Autor:
Tong Zhang, Hedvig Tamman, Kyo Coppieters ’t Wallant, Tatsuaki Kurata, Michele LeRoux, Sriram Srikant, Tetiana Brodiazhenko, Albinas Cepauskas, Ariel Talavera, Chloe Martens, Gemma C. Atkinson, Vasili Hauryliuk, Abel Garcia-Pino, Michael T. Laub
Publikováno v:
Nature. 612(7938)
Bacteria have evolved diverse immunity mechanisms to protect themselves against the constant onslaught of bacteriophages1–3. Similar to how eukaryotic innate immune systems sense foreign invaders through pathogen-associated molecular patterns4 (PAM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39250ac3e2293d5b1f1082713838c56b
https://pubmed.ncbi.nlm.nih.gov/36385533
https://pubmed.ncbi.nlm.nih.gov/36385533