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Akademický článek

Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders

Autor: Leandro R Soria, Sonam Gurung, Giulia De Sabbata, Dany P Perocheau, Angela De Angelis, Gemma Bruno, Elena Polishchuk, Debora Paris, Paola Cuomo, Andrea Motta, Michael Orford, Youssef Khalil, Simon Eaton, Philippa B Mills, Simon N Waddington, Carmine Settembre, Andrés F Muro, Julien Baruteau, Nicola Brunetti‐Pierri

Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-14 (2020)

Abstract Urea cycle disorders (UCD) are inherited defects in clearance of waste nitrogen with high morbidity and mortality. Novel and more effective therapies for UCD are needed. Studies in mice with constitutive activation of autophagy unravelled Be

Externí odkaz: https://doaj.org/article/19085dda865a4f648e70bb866bfbf0bc

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Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders

Autor: Simon N. Waddington, Julien Baruteau, Andrea Motta, Gemma Bruno, Carmine Settembre, Youssef Khalil, Andrés F. Muro, Simon Eaton, Leandro R. Soria, Giulia De Sabbata, Elena Polishchuk, Michael Orford, Nicola Brunetti-Pierri, Debora Paris, Sonam Gurung, Philippa B. Mills, Dany P. Perocheau, Paola Cuomo, Angela De Angelis

Publikováno v: EMBO molecular medicine
e13158 (2021). doi:10.15252/emmm.202013158
info:cnr-pdr/source/autori:Soria L.R.; Gurung S.; De Sabbata G.; Perocheau D.P.; De Angelis A.; Bruno G.; Polishchuk E.; Paris D.; Cuomo P.; Motta A.; Orford M.; Khalil Y.; Eaton S.; Mills P.B.; Waddington S.N.; Settembre C.; Muro A.F.; Baruteau J.; Brunetti-Pierri N./titolo:Beclin-1-mediated activation of autophagy improves proximal and distal urea cycle disorders/doi:10.15252%2Femmm.202013158/rivista:EMBO molecular medicine (Print)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:e13158
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 13, Iss 2, Pp n/a-n/a (2021)

Urea cycle disorders (UCD) are inherited defects in clearance of waste nitrogen with high morbidity and mortality. Novel and more effective therapies for UCD are needed. Studies in mice with constitutive activation of autophagy unravelled Beclin‐1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ffd02cc8ee0837f2c0100ea80ddc6e
https://doi.org/10.15252/emmm.202013158

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A selective ER ‐phagy exerts procollagen quality control via a Calnexin‐ FAM 134B complex

Autor: Alison Forrester, Alessandro Marazza, Elisa Fasana, Ivan Dikic, Leopoldo Staiano, Marilina Piemontese, Maria Iavazzo, Carmine Settembre, Gemma Bruno, Chiara De Leonibus, Daniela Intartaglia, Ilaria Fregno, Maria Antonietta De Matteis, Ivan Conte, Marta Seczynska, Paolo Grumati, Maurizio Molinari, Eelco van Anken, Andrea Raimondi

Publikováno v: The EMBO Journal
The EMBO Journal, 38 (2)
Forrester, Alison; De Leonibus, Chiara; Grumati, Paolo; Fasana, Elisa; Piemontese, Marilina; Staiano, Leopoldo; Fregno, Ilaria; Raimondi, Andrea; Marazza, Alessandro; Bruno, Gemma; Iavazzo, Maria; Intartaglia, Daniela; Seczynska, Marta; van Anken, Eelco; Conte, Ivan; De Matteis, Maria Antonietta; Dikic, Ivan; Molinari, Maurizio; Settembre, Carmine (2019). A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex. The EMBO journal, 38(2) EMBO Press 10.15252/embj.201899847

Autophagy is a cytosolic quality control process that recognizes substrates through receptor-mediated mechanisms. Procollagens, the most abundant gene products in Metazoa, are synthesized in the endoplasmic reticulum (ER), and a fraction that fails t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d90a9a101caad5263826db8a7ffe313

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Thiirancarboxamides as Inhibitors of Papain

Autor: Gemma Bruno, Tanja Schirmeister

Publikováno v: Archiv der Pharmazie. 337:90-95

Derivatives of the thiirancarboxylic acid building-block containing a peptide bond were synthesised and screened against the model cysteine protease papain. The most active of the series showed a second-order rate constant of inactivation comparable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba0ada0c61bd2c7f8a3f54b588f40aa
https://doi.org/10.1002/ardp.200300820

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Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity

Autor: Vincenzo Tortorella, and Diana Conte Camerino, Gemma Bruno, Antonio Scilimati, Carlo Franchini, Giovanni Lentini, Annamaria De Luca, Filomena Corbo

Publikováno v: Journal of medicinal chemistry. 43(20)

A series of tocainide chiral analogues were designed, synthesized, and evaluated in vitro, in pure enantiomeric form, as use-dependent blockers of skeletal muscle sodium channels to better understand the structural requirements responsible for the an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82c117d1c373a3467fb65f71976bd48
https://pubmed.ncbi.nlm.nih.gov/11020295

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Akademický článek

Current methods to analyze lysosome morphology, positioning, motility and function.

Autor: Barral, Duarte C.¹ (AUTHOR) duarte.barral@nms.unl.pt, Staiano, Leopoldo^2,3 (AUTHOR), Guimas Almeida, Cláudia¹ (AUTHOR), Cutler, Dan F.⁴ (AUTHOR), Eden, Emily R.⁵ (AUTHOR), Futter, Clare E.⁵ (AUTHOR), Galione, Antony⁶ (AUTHOR), Marques, André R. A.¹ (AUTHOR), Medina, Diego Luis^2,7 (AUTHOR), Napolitano, Gennaro^2,7 (AUTHOR), Settembre, Carmine^2,8 (AUTHOR), Vieira, Otília V.¹ (AUTHOR), Aerts, Johannes M. F. G.⁹ (AUTHOR), Atakpa‐Adaji, Peace¹⁰ (AUTHOR), Bruno, Gemma² (AUTHOR), Capuozzo, Antonella² (AUTHOR), De Leonibus, Elvira^2,11 (AUTHOR), Di Malta, Chiara^2,7 (AUTHOR), Escrevente, Cristina¹ (AUTHOR), Esposito, Alessandra² (AUTHOR)

Publikováno v: Traffic. May2022, Vol. 23 Issue 5, p238-269. 32p.

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