Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Gemma, Fisher"'
Autor:
Gemma Fisher, Marina Corbella, Magnus S. Alphey, John Nicholson, Benjamin J. Read, Shina C. L. Kamerlin, Rafael G. da Silva
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
ATPPRT is a multi-protein allosteric enzyme where the regulatory protein HisZ enhances catalysis by HisGs. Here, the authors report catalytically impaired active site mutants of HisGs that are allosterically rescued by HisZ despite the HisZ:HisGs int
Externí odkaz:
https://doaj.org/article/c345a6e16afe41afb597176f4ea0ea08
Autor:
Gemma Fisher, Ennio Pečaver, Benjamin J. Read, Susannah K. Leese, Erin Laing, Alison L. Dickson, Clarissa M. Czekster, Rafael G. da Silva
Publikováno v:
ACS Catalysis. :7669-7679
Funding: This study was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) (Grant BB/M010996/1) via EASTBIO Doctoral Training Partnership studentships to G.F. and B.J.R., and by the University of St Andrews via a StARIS s
Autor:
Gemma Fisher, Laurane Mackels, Theodora Markati, Anna Sarkozy, Julien Ochala, Heinz Jungbluth, Sithara Ramdas, Laurent Servais
Publikováno v:
Fisher, G, Mackels, L, Markati, T, Sarkozy, A, Ochala, J, Jungbluth, H, Ramdas, S & Servais, L 2022, ' Early clinical and pre-clinical therapy development in Nemaline myopathy ', Expert Opinion On Therapeutic Targets, vol. 26, no. 10, pp. 853–867 . https://doi.org/10.1080/14728222.2022.2157258
IntroductionNemaline myopathies (NM) represent a group of clinically and genetically heterogeneous congenital muscle disorders with the common denominator of nemaline rods on muscle biopsy. NEB and ACTA1 are the most common causative genes. Currently
Publikováno v:
Paediatric Clinical Leaders: Service Planning, Provision and Best Practice.
Autor:
Pamela Sweeney, Ashleigh Galliford, Abhishek Kumar, Dinesh Raju, Naveen B. Krishna, Emmajay Sutherland, Caitlin J. Leo, Gemma Fisher, Roopa Lalitha, Likith Muthuraj, Gladstone Sigamani, Verena Oehler, Silvia Synowsky, Sally L. Shirran, Tracey M. Gloster, Clarissa M. Czekster, Pravin Kumar, Rafael G. da Silva
This work was supported by a Wellcome Trust Seed Award in Science [208980/Z/17/Z] to RGdS; a University of St Andrews/Scottish Funding Council St Andrews Restarting Research Fund to RGdS; and a Wellcome Trust Institutional Strategic Support Fund [204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08da56da0a5a8e7b1fd74ba9111e89f5
https://hdl.handle.net/10023/25512
https://hdl.handle.net/10023/25512
Autor:
Benjamin J. Read, Gemma Fisher, Oliver L. R. Wissett, Teresa F. G. Machado, John Nicholson, John B. O. Mitchell, Rafael G. da Silva
This work was supported by the Biotechnology and Biological Sciences Research Council (BBSRC) (Grant BB/M010996/1) via EASTBIO Doctoral Training Partnership studentships to B.J.R. and G.F., and by the Engineering and Physical Sciences Research Counci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8f27fefe60c1f31613e0c53eee030d
https://hdl.handle.net/10023/26626
https://hdl.handle.net/10023/26626
Spinal muscular atrophy (SMA) is a rare autosomal recessive neuromuscular disease which is characterised by muscle atrophy and early death in most patients. Risdiplam is the third overall and first oral drug approved for SMA with disease-modifying po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976ac9370fb2c9052d14bb451691c3d0
Autor:
Pamela, Sweeney, Ashleigh, Galliford, Abhishek, Kumar, Dinesh, Raju, Naveen B, Krishna, Emmajay, Sutherland, Caitlin J, Leo, Gemma, Fisher, Roopa, Lalitha, Likith, Muthuraj, Gladstone, Sigamani, Verena, Oehler, Silvia, Synowsky, Sally L, Shirran, Tracey M, Gloster, Clarissa M, Czekster, Pravin, Kumar, Rafael G, da Silva
Publikováno v:
The Journal of biological chemistry. 298(6)
The enzyme m
Autor:
Pamela Sweeney, Ashleigh Crowe, Abhishek Kumar, Dinesh Raju, Naveen B. Krishna, Emmajay Sutherland, Caitlin J. Leo, Gemma Fisher, Roopa Lalitha, Likith Muthuraj, Gladstone Sigamani, Verena Oehler, Silvia Synowsky, Sally L. Shirran, Tracey M. Gloster, Clarissa M. Czekster, Pravin Kumar, Rafael G. da Silva
The enzyme m1A22-tRNA methyltransferase (TrmK) catalyses the transfer of a methyl group from SAM to the N1 of adenine 22 in tRNAs. TrmK is essential for Staphylococcus aureus survival during infection, but has no homologue in mammals, making it a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6952c89b3e51b9b8d47024c86f7520b6
https://doi.org/10.1101/2021.12.24.474102
https://doi.org/10.1101/2021.12.24.474102
Autor:
Benjamin J, Read, Gemma, Fisher, Oliver L R, Wissett, Teresa F G, Machado, John, Nicholson, John B O, Mitchell, Rafael G, da Silva
Publikováno v:
ACS infectious diseases. 8(1)
ATP phosphoribosyltransferase (ATPPRT) catalyzes the first step of histidine biosynthesis in bacteria, namely, the condensation of ATP and 5-phospho-α-d-ribosyl-1-pyrophosphate (PRPP) to generate