Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gemechu, Mekonnen"'
Publikováno v:
eLife, Vol 11 (2022)
Precise control of protein degradation is critical for life, yet how natural genetic variation affects this essential process is largely unknown. Here, we developed a statistically powerful mapping approach to characterize how genetic variation affec
Externí odkaz:
https://doaj.org/article/989bd8379f784ce7ba38a9fdec8b6e37
Autor:
Motohiro Nakajima, Abdul Sero, Shamso Jama, Sara Habte, Sartu Taha, Hileena Habte, Gemechu Mekonnen, Iman Geleto, Stephan Bongard, Mustafa al’Absi
Publikováno v:
Journal of Psychoactive Drugs. 55:112-121
While tobacco use rates are relatively high among East African immigrants in the U.S., factors contributing to this high rate are largely unknown. Acculturation is associated with stress and substance use. Whether acculturation styles are related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db614eaf85d93ad234a9ca616124c1c
https://doi.org/10.1080/02791072.2022.2040659
https://doi.org/10.1080/02791072.2022.2040659
Autor:
X. Rosa Ma, Mercedes Prudencio, Yuka Koike, Sarat C. Vatsavayai, Garam Kim, Fred Harbinski, Adam Briner, Caitlin M. Rodriguez, Caiwei Guo, Tetsuya Akiyama, H. Broder Schmidt, Beryl B. Cummings, David W. Wyatt, Katherine Kurylo, Georgiana Miller, Shila Mekhoubad, Nathan Sallee, Gemechu Mekonnen, Laura Ganser, Jack D. Rubien, Karen Jansen-West, Casey N. Cook, Sarah Pickles, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, James Shorter, Sua Myong, Eric M. Green, William W. Seeley, Leonard Petrucelli, Aaron D. Gitler
Publikováno v:
Nature. 603:124-130
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f758b8c837195288f92794e856595a83
https://doi.org/10.1038/s41586-022-04424-7
https://doi.org/10.1038/s41586-022-04424-7
Autor:
X Rosa, Ma, Mercedes, Prudencio, Yuka, Koike, Sarat C, Vatsavayai, Garam, Kim, Fred, Harbinski, Adam, Briner, Caitlin M, Rodriguez, Caiwei, Guo, Tetsuya, Akiyama, H Broder, Schmidt, Beryl B, Cummings, David W, Wyatt, Katherine, Kurylo, Georgiana, Miller, Shila, Mekhoubad, Nathan, Sallee, Gemechu, Mekonnen, Laura, Ganser, Jack D, Rubien, Karen, Jansen-West, Casey N, Cook, Sarah, Pickles, Björn, Oskarsson, Neill R, Graff-Radford, Bradley F, Boeve, David S, Knopman, Ronald C, Petersen, Dennis W, Dickson, James, Shorter, Sua, Myong, Eric M, Green, William W, Seeley, Leonard, Petrucelli, Aaron D, Gitler
Publikováno v:
Nature, vol 603, iss 7899
A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord1. A major
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::821110b3bc35110fc73e4b0933142d1d
https://escholarship.org/uc/item/1062r1nd
https://escholarship.org/uc/item/1062r1nd
Autor:
Mark A. Sanders, Gabriela Huelgas-Morales, Tatsuya Tsukamoto, Gemechu Mekonnen, David Greenstein
Publikováno v:
Proceedings of the National Academy of Sciences. 117:31301-31308
The function of the nucleus depends on the integrity of the nuclear lamina, an intermediate filament network associated with the linker of nucleoskeleton and cytoskeleton (LINC) complex. The LINC complex spans the nuclear envelope and mediates nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::567eb83b2e1dc24072fc023f6dcf559f
https://doi.org/10.1073/pnas.2015050117
https://doi.org/10.1073/pnas.2015050117
Autor:
Gemechu Mekonnen, David Greenstein, Seongseop Kim, Caroline A. Spike, Tatsuya Tsukamoto, Micah D. Gearhart
Publikováno v:
Genetics. 214:869-893
Mutations affecting spliceosomal proteins are frequently found in hematological malignancies. DDX41/Abstrakt is a metazoan-specific spliceosomal DEAD-box RNA helicase found to be recurrently mutated in relapsing cases of acute myeloid leukemia, as we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e795ff50cd594f5b8d553fdfb24669bf
https://doi.org/10.1534/genetics.119.302973
https://doi.org/10.1534/genetics.119.302973
Ubiquitin-proteasome system (UPS) protein degradation regulates protein abundance and eliminates mis-folded and damaged proteins from eukaryotic cells. Variation in UPS activity influences numerous cellular and organismal phenotypes. However, to what
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe934a1578991dd346b0bf2d635da5ac
https://doi.org/10.1101/2021.05.05.442832
https://doi.org/10.1101/2021.05.05.442832
Publikováno v:
Genetics
Gene expression differences among individuals are shaped by trans-acting expression quantitative trait loci (eQTLs). Most trans-eQTLs map to hotspot locations that influence many genes. The molecular mechanisms perturbed by hotspots are often assumed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b92568194824d052d8a63d6b127a1e
https://doi.org/10.1093/genetics/iyaa051
https://doi.org/10.1093/genetics/iyaa051
Autor:
Gabriela, Huelgas-Morales, Mark, Sanders, Gemechu, Mekonnen, Tatsuya, Tsukamoto, David, Greenstein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Nuclear envelopathies are a complex group of human diseases caused by mutations in nuclear envelope proteins, including progeria, myopathy, and dystonia. Here, we used the Caenorhabditis elegans germline as a model system to investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5bf14a4c772a9d63bcd50090990fb9b
https://pubmed.ncbi.nlm.nih.gov/33229589
https://pubmed.ncbi.nlm.nih.gov/33229589