Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gema Tarrasón"'
Autor:
Nuria Godessart, Anselm Morell, Amedeu Gavaldà, Severiano Marín, Pedro Navalón, Julio Cortijo, Javier Milara, Gema Tarrasón, Laurabel Gozalbes
Publikováno v:
European journal of dermatology : EJD. 31(3)
Topical α1- and α2-adrenoreceptor (ADRA1 and 2) agonists are effective in alleviating permanent vasodilation and facial erythema associated with rosacea by inducing skin vasoconstriction. Although β-adrenoreceptor (ADRB) antagonists are used off-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd64d6c95dc57dfa21703b532b37d78
https://pubmed.ncbi.nlm.nih.gov/34309518
https://pubmed.ncbi.nlm.nih.gov/34309518
Autor:
Laura Vidal, Sonia Sentellas, Gema Tarrasón, Soledad Alzina, Silvia Gual, Bernat Vidal, Cristina Esteve, Irene Jover, Jacob González, Jorge De Alba, Montserrat Miralpeix, Raquel Horrillo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1217-1222
Synthesis and SAR of a series of 7-azaindoles as Orai channel inhibitors showing good potency inhibiting IL-2 production in Jurkat cells is described. Compound 14d displaying best pharmacokinetic properties was further characterized in a model of all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825a7ee7d35a2e46075e136353eb9a3f
https://doi.org/10.1016/j.bmcl.2015.01.063
https://doi.org/10.1016/j.bmcl.2015.01.063
Autor:
Carla Carcasona, Gema Tarrasón, Nuria Godessart, Bibiana Pérez, Peter Eichhorn, Amadeu Gavaldà
Publikováno v:
Experimental dermatology. 26(11)
Pruritus is a major symptom of several dermatological diseases but has limited therapeutic options available. Animal models replicating the pathophysiology of pruritus are needed to support the development of new drugs. Induction of pruritus by chlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a953ab82acfa550280f0d9755806374
https://pubmed.ncbi.nlm.nih.gov/28605064
https://pubmed.ncbi.nlm.nih.gov/28605064
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists
Autor:
Gema Tarrasón, Nuria Godessart, Marta Mir, Clara Armengol, Mònica Córdoba, Dolors Vilella, Daniel Casals, Manel López, Victor Segarra, Teresa Doménech, Imma Moreno, M Sabate, Nuria Aguilar, Pedro M. Grima, María Domínguez, Laia Esteban
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7672-7676
Amido-1,3,4-thiadiazoles have been identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype 1 agonists. Starting from a micromolar HTS hit with the help of an in-house homology model, robust structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::267ca19860dca563219d7e83fee9d6af
https://doi.org/10.1016/j.bmcl.2012.09.110
https://doi.org/10.1016/j.bmcl.2012.09.110
Autor:
Richard S. Roberts, Montserrat Miralpeix, Jorge De Alba, Carla Carcasona, Peter Eichhorn, Amadeu Gavaldà, Irene Jover, Mònica Aparici, Joan Antoni Fernandez-Blanco, Gema Tarrasón
Publikováno v:
5.1 Airway Pharmacology and Treatment.
Introduction: Treatment of chronic cough is an unmet medical need impairing patients9 quality of life. Transient Receptor Potential Ankyrin 1 (TRPA1) channels may provide a safe opportunity to target cough response at the periphery of the cough refle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242beadfb84f7fba8764a543d4a5e408
https://doi.org/10.1183/13993003.congress-2015.pa3948
https://doi.org/10.1183/13993003.congress-2015.pa3948
Autor:
Jorge De Alba, Neus Prats, Gema Tarrasón, Anna Domènech, Mònica Aguilera, Montse Miralpeix, Joan Antoni Fernandez-Blanco
Publikováno v:
Clinical science (London, England : 1979). 129(12)
Fibrotic lung diseases, such as idiopathic pulmonary fibrosis, are associated with spontaneous dry cough and hypersensitivity to tussive agents. Understanding the pathophysiology driving enhanced cough may help us to define better therapies for patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edb2c7bde6c95c6bfc02f638b7e917ee
https://pubmed.ncbi.nlm.nih.gov/26275723
https://pubmed.ncbi.nlm.nih.gov/26275723
Autor:
Gema Tarrasón, Jaume Piulats
Publikováno v:
Revista de Oncología. 3:241-249
Tumor cells have developed successful mechanisms to escape the normal controls that regulate cell proliferation and apoptosis. Basic research can help in the processes of target discovery for designing new therapeutic interventions in oncology based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e15190644b0bf396630b609ee68b592
https://doi.org/10.1007/bf02719883
https://doi.org/10.1007/bf02719883
Autor:
Marten Wiersma, Ramon Eritja, Hartmut Seliger, Dirk Gottschling, Gema Tarrasón, Jaume Piulats
Publikováno v:
Scopus-Elsevier
The preparation of peptide nucleic acids (PNA)carrying a c-myc tag-peptide sequence isdescribed. These PNA-peptide chimeras have higheraffinity to complementary DNA than unmodifiedoligonucleotides. Moreover, they can be used asnonradioactive probes w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f27f7b8d719f2b43cc2bc78334dc68
https://doi.org/10.1007/bf02443560
https://doi.org/10.1007/bf02443560
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P₁ direct agonists
Autor:
Nuria, Aguilar, Marta, Mir, Pedro M, Grima, Manel, López, Victor, Segarra, Laia, Esteban, Imma, Moreno, Nuria, Godessart, Gema, Tarrasón, Teresa, Domenech, Dolors, Vilella, Clara, Armengol, Mònica, Córdoba, Mar, Sabaté, Daniel, Casals, Maria, Domínguez
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(24)
Amido-1,3,4-thiadiazoles have been identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype 1 agonists. Starting from a micromolar HTS hit with the help of an in-house homology model, robust structural-a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b6d390fb1e124b77845c2f17ba30813
https://pubmed.ncbi.nlm.nih.gov/23141913
https://pubmed.ncbi.nlm.nih.gov/23141913
