Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Gema Medina"'
Autor:
Marjorie Reyes-Farias, Pablo Fernández-García, Patricia Corrales, Lorena González, Andrea Soria-Gondek, Ester Martínez, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Gema Medina-Gómez, David Sánchez-Infantes, Laura Herrero
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionObesity is a chronic condition associated with low-grade inflammation mainly due to immune cell infiltration of white adipose tissue (WAT). WAT is distributed into two main depots: subcutaneous WAT (sWAT) and visceral WAT (vWAT), each wit
Externí odkaz:
https://doaj.org/article/46ecdbfb5c214e5cb4b3739574a93116
Autor:
Miguel M. Garcia, Patricia Corrales, Miguel Á. Huerta, Maciej J. Czachorowski, Visitación López-Miranda, Gema Medina-Gómez, Enrique J. Cobos, Carlos Goicoechea, Miguel Molina-Álvarez
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
ContextOver 1.9 billion adult people have overweight or obesity. Considered as a chronic disease itself, obesity is associated with several comorbidities. Chronic pain affects approximately 60 million people and its connection with obesity has been d
Externí odkaz:
https://doaj.org/article/a8015baca6e14f41851bc7a039727400
Autor:
Ionel Sandovici, Constanze M. Hammerle, Sam Virtue, Yurena Vivas-Garcia, Adriana Izquierdo-Lahuerta, Susan E. Ozanne, Antonio Vidal-Puig, Gema Medina-Gómez, Miguel Constância
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in
Externí odkaz:
https://doaj.org/article/418fc450d39f40d4b1305155c0e3ac81
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 2, Pp 151221- (2022)
Fibrosis is a physiological process of tissue repair that turns into pathological when becomes chronic, damaging the functional structure of the tissue. In this review we outline the current status of extracellular vesicles as modulators of the fibro
Externí odkaz:
https://doaj.org/article/d37ba99b11454b55969c03ebe492eea0
Autor:
Albert Lecube, Enric Sánchez, Susana Monereo, Gema Medina-Gómez, Diego Bellido, José Manuel García-Almeida, Purificación Martínez de Icaya, Maria Mar Malagón, Albert Goday, Francisco José Tinahones
Publikováno v:
Obesity Facts, Pp 1-11 (2020)
Objective: Our aim was to go deeper in the self-perception of weight and health status among the Spanish population, together with the connections of familiar relationships, physical activity practice, nutritional habits, and sleep patterns with the
Externí odkaz:
https://doaj.org/article/8133689a95054bccbd9553d800291a37
Autor:
Elia Escasany, Borja Lanzón, Almudena García-Carrasco, Adriana Izquierdo-Lahuerta, Lucía Torres, Patricia Corrales, Ana Elena Rodríguez Rodríguez, Sergio Luis-Lima, Concepción Martínez Álvarez, Francisco Javier Ruperez, Manuel Ros, Esteban Porrini, Mikael Rydén, Gema Medina-Gómez
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 9 (2021)
Glomerulosclerosis and tubulointerstitial fibrosis are pathological features of chronic kidney disease. Transforming growth factor β (TGFβ) is a key player in the development of fibrosis. However, of the three known TGFβ isoforms, only TGFβ1 has
Externí odkaz:
https://doaj.org/article/26203ee769374ec994146a2fd03c48f1
Autor:
Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L. Labandeira-García, Rubén Nogueiras, Ana I. Domingos, José-Manuel Fernández-Real, Kamal Rahmouni, Carlos Diéguez, Miguel López
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nicotine reduces food intake and increases energy expenditure in brown adipose tissue. Here the authors show that nicotine also induces white adipose tissue browning via central kappa opioid receptor action.
Externí odkaz:
https://doaj.org/article/a1356a9614a84addacb065641889c5db
Autor:
Constanze M Hammerle, Ionel Sandovici, Gemma V Brierley, Nicola M Smith, Warren E Zimmer, Ilona Zvetkova, Haydn M Prosser, Yoichi Sekita, Brian Y H Lam, Marcella Ma, Wendy N Cooper, Antonio Vidal-Puig, Susan E Ozanne, Gema Medina-Gómez, Miguel Constância
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009069 (2020)
The genetic mechanisms that determine the size of the adult pancreas are poorly understood. Imprinted genes, which are expressed in a parent-of-origin-specific manner, are known to have important roles in development, growth and metabolism. However,
Externí odkaz:
https://doaj.org/article/dd9ff8b3a079402997344c273ba5478c
Autor:
Borja Lanzon, Marina Martin-Taboada, Victor Castro-Alves, Rocio Vila-Bedmar, Ignacio González de Pablos, Daniel Duberg, Pilar Gomez, Elias Rodriguez, Matej Orešič, Tuulia Hyötyläinen, Enrique Morales, Francisco J. Ruperez, Gema Medina-Gomez
Publikováno v:
Metabolites, Vol 11, Iss 12, p 836 (2021)
Severe obesity is a major risk for chronic kidney disease (CKD). Early detection and careful monitoring of renal function are critical for the prevention of CKD during obesity, since biopsies are not performed in patients with CKD and diagnosis is de
Externí odkaz:
https://doaj.org/article/05f037bcb00e4696978c287723fdb7ab
Autor:
Yurena Vivas, Monica Díez-Hochleitner, Adriana Izquierdo-Lahuerta, Patricia Corrales, Daniel Horrillo, Ismael Velasco, Cristina Martínez-García, Mark Campbell, Julio Sevillano, Mercedes Ricote, Manuel Ros, Maria Pilar Ramos, Gema Medina-Gomez
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 724-736 (2016)
Abstract Pregnancy requires adaptation of maternal energy metabolism, including expansion and functional modifications of adipose tissue. Insulin resistance (IR), predominantly during late gestation, is a physiological metabolic adaptation that serve
Externí odkaz:
https://doaj.org/article/1c4fbee09600426bb885ffe52e335d99