The Mitogen-Activated Protein Kinase Slt2 Promotes Asymmetric Cell Cycle Arrest and Reduces TORC1-Sch9 Signaling in Yeast Lacking the Protein Phosphatase Ptc1

Autor: Gema González-Rubio, Humberto Martín, María Molina

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT Mitogen-activated protein kinase (MAPK) pathways regulate essential processes in eukaryotes. However, since uncontrolled activation of these cascades has deleterious effects, precise negative regulation of signaling flow through them, mainly

Externí odkaz: https://doaj.org/article/b1c3164a89944d56b4a7f19c0ba5b250

Differential Role of Threonine and Tyrosine Phosphorylation in the Activation and Activity of the Yeast MAPK Slt2

Autor: Gema González-Rubio, Ángela Sellers-Moya, Humberto Martín, María Molina

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 3, p 1110 (2021)

The Mitogen-Activated Protein Kinase (MAPK) Slt2 is central to signaling through the yeast Cell Wall Integrity (CWI) pathway. MAPKs are regulated by phosphorylation at both the threonine and tyrosine of the conserved TXY motif within the activation l

Externí odkaz: https://doaj.org/article/1f08fceaa235461aa24b336ee731b57b

A walk-through MAPK structure and functionality with the 30-year-old yeast MAPK Slt2

Autor: Gema González-Rubio, Humberto Martín, María Molina, Ángela Sellers-Moya

Publikováno v: International microbiology : the official journal of the Spanish Society for Microbiology. 24(4)

Mitogen-activated protein kinases (MAPKs) are evolutionarily conserved signaling proteins involved in the regulation of most eukaryotic cellular processes. They are downstream components of essential signal transduction pathways activated by the exte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4a87a123a0b2656efe29a92bb4cb64
https://pubmed.ncbi.nlm.nih.gov/33993419

Mitogen-Activated Protein Kinase Phosphatases (MKPs) in Fungal Signaling: Conservation, Function, and Regulation

Autor: Humberto Martín, Teresa Fernández-Acero, Gema González-Rubio, María Molina

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1709 (2019)
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM
instname

Mitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. Since the precise regulation of MAPKs is fundamental for cell physiology, fungi bear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208d984e33e6c423fe82098d574cf3aa
https://pubmed.ncbi.nlm.nih.gov/30959830